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Wikipedia

ABCA8

From Wikipedia, the free encyclopedia

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ATP-binding cassette, sub-family A (ABC1), member 8
Identifiers
SymbolsABCA8; KIAA0822; MGC163152
External IDsMGI1351668 HomoloGene56029 GeneCards: ABCA8 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1035127404
EnsemblENSG00000141338ENSMUSG00000020620
UniProtO94911Q8K440
RefSeq (mRNA)NM_007168NM_013851
RefSeq (protein)NP_009099NP_038879
Location (UCSC)Chr 17:
64.38 - 64.46 Mb
Chr 11:
109.75 - 109.81 Mb
PubMed search[1][2]

ATP-binding cassette sub-family A member 8 is a protein that in humans is encoded by the ABCA8 gene.[1]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The function of this protein has not yet been determined.[1]

References

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tsuruoka S, Ishibashi K, Yamamoto H, et al. (2002). [Expression error: Missing operand for > "Functional analysis of ABCA8, a new drug transporter."]. Biochem. Biophys. Res. Commun. 298 (1): 41–5. doi:10.1016/S0006-291X(02)02389-6. PMID 12379217. 
  • Iida A, Saito S, Sekine A, et al. (2002). [Expression error: Missing operand for > "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."]. J. Hum. Genet. 47 (6): 285–310. doi:10.1007/s100380200041. PMID 12111378. 
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). [Expression error: Missing operand for > "Creation of genome-wide protein expression libraries using random activation of gene expression."]. Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). [Expression error: Missing operand for > "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."]. DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. 
  • Bonaldo MF, Lennon G, Soares MB (1997). [Expression error: Missing operand for > "Normalization and subtraction: two approaches to facilitate gene discovery."]. Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 


 

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