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definition - ATP2B1

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ATP2B1

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ATPase, Ca++ transporting, plasma membrane 1
Identifiers
SymbolsATP2B1; PMCA1
External IDsOMIM108731 MGI104653 HomoloGene55597 GeneCards: ATP2B1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez49067972
EnsemblENSG00000070961ENSMUSG00000019943
UniProtP20020n/a
RefSeq (mRNA)NM_001001323NM_026482
RefSeq (protein)NP_001001323NP_080758
Location (UCSC)Chr 12:
88.51 - 88.57 Mb
Chr 10:
98.34 - 98.45 Mb
PubMed search[1][2]

Plasma membrane calcium-transporting ATPase 1 is an enzyme that in humans is encoded by the ATP2B1 gene.[1][2]

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References

  1. ^ Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (Jul 1991). [Expression error: Missing operand for > "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23"]. Genomics 9 (4): 629-41. PMID 1674727. 
  2. ^ a b "Entrez Gene: ATP2B1 ATPase, Ca++ transporting, plasma membrane 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=490. 

Further reading

  • Møller JV, Juul B, le Maire M (1996). [Expression error: Missing operand for > "Structural organization, ion transport, and energy transduction of P-type ATPases."]. Biochim. Biophys. Acta 1286 (1): 1–51. PMID 8634322. 
  • Strehler EE, Zacharias DA (2001). [Expression error: Missing operand for > "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps."]. Physiol. Rev. 81 (1): 21–50. PMID 11152753. 
  • Strehler EE, Treiman M (2004). [Expression error: Missing operand for > "Calcium pumps of plasma membrane and cell interior."]. Curr. Mol. Med. 4 (3): 323–35. doi:10.2174/1566524043360735. PMID 15101689. 
  • Kessler F, Falchetto R, Heim R, et al. (1992). [Expression error: Missing operand for > "Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump."]. Biochemistry 31 (47): 11785–92. doi:10.1021/bi00162a016. PMID 1332771. 
  • Wang KK, Wright LC, Machan CL, et al. (1991). [Expression error: Missing operand for > "Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes."]. J. Biol. Chem. 266 (14): 9078–85. PMID 1827443. 
  • Strehler EE, Strehler-Page MA, Vogel G, Carafoli E (1989). [Expression error: Missing operand for > "mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon."]. Proc. Natl. Acad. Sci. U.S.A. 86 (18): 6908–12. doi:10.1073/pnas.86.18.6908. PMID 2528729. 
  • James PH, Pruschy M, Vorherr TE, et al. (1989). [Expression error: Missing operand for > "Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump."]. Biochemistry 28 (10): 4253–8. doi:10.1021/bi00436a020. PMID 2548572. 
  • Verma AK, Filoteo AG, Stanford DR, et al. (1988). [Expression error: Missing operand for > "Complete primary structure of a human plasma membrane Ca2+ pump."]. J. Biol. Chem. 263 (28): 14152–9. PMID 2844759. 
  • Howard A, Legon S, Walters JR (1993). [Expression error: Missing operand for > "Human and rat intestinal plasma membrane calcium pump isoforms."]. Am. J. Physiol. 265 (5 Pt 1): G917–25. PMID 7694502. 
  • Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1995). [Expression error: Missing operand for > "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."]. J. Biol. Chem. 269 (50): 32022. PMID 7989379. 
  • Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (1994). [Expression error: Missing operand for > "Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes."]. J. Biol. Chem. 268 (34): 25993–6003. PMID 8245032. 
  • Kumar R, Haugen JD, Penniston JT (1993). [Expression error: Missing operand for > "Molecular cloning of a plasma membrane calcium pump from human osteoblasts."]. J. Bone Miner. Res. 8 (4): 505–13. PMID 8386431. 
  • Hilfiker H, Strehler-Page MA, Stauffer TP, et al. (1993). [Expression error: Missing operand for > "Structure of the gene encoding the human plasma membrane calcium pump isoform 1."]. J. Biol. Chem. 268 (26): 19717–25. PMID 8396145. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). [Expression error: Missing operand for > "A "double adaptor" method for improved shotgun library construction."]. Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Bonaldo MF, Lennon G, Soares MB (1997). [Expression error: Missing operand for > "Normalization and subtraction: two approaches to facilitate gene discovery."]. Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Benkwitz C, Kubisch C, Kraft K, Neyses L (1997). [Expression error: Missing operand for > "Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique."]. J. Mol. Med. 75 (1): 62–6. doi:10.1007/s001090050088. PMID 9020386. 
  • Yu W, Andersson B, Worley KC, et al. (1997). [Expression error: Missing operand for > "Large-scale concatenation cDNA sequencing."]. Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Elshorst B, Hennig M, Försterling H, et al. (1999). [Expression error: Missing operand for > "NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump."]. Biochemistry 38 (38): 12320–32. doi:10.1021/bi9908235. PMID 10493800. 

 

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