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BoggleAlpha-2A adrenergic receptor
From Wikipedia, the free encyclopedia
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The alpha-2A adrenergic receptor (α2A adrenoreceptor), also known as ADRA2A, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.[1]
Contents |
Receptor
Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity.
Gene
This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.[1]
Selective Ligands
Agonists
Antagonists
See also
References
External links
- "α2A-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2181.
Further reading
- Perälä M, Hirvonen H, Kalimo H, et al. (1993). [Expression error: Missing operand for > "Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues."]. Brain Res. Mol. Brain Res. 16 (1-2): 57–63. doi:. PMID 1334200.
- Surprenant A, Horstman DA, Akbarali H, Limbird LE (1992). [Expression error: Missing operand for > "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents."]. Science 257 (5072): 977–80. doi:. PMID 1354394.
- Handy DE, Gavras H (1992). [Expression error: Missing operand for > "Promoter region of the human alpha 2A adrenergic receptor gene."]. J. Biol. Chem. 267 (33): 24017–22. PMID 1385431.
- Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK (1991). [Expression error: Missing operand for > "A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists."]. J. Biol. Chem. 266 (23): 15488–92. PMID 1678390.
- Wang CD, Buck MA, Fraser CM (1991). [Expression error: Missing operand for > "Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists."]. Mol. Pharmacol. 40 (2): 168–79. PMID 1678850.
- Chhajlani V, Rangel N, Uhlén S, Wikberg JE (1991). [Expression error: Missing operand for > "Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR."]. FEBS Lett. 280 (2): 241–4. doi:. PMID 1849485.
- Guyer CA, Horstman DA, Wilson AL, et al. (1990). [Expression error: Missing operand for > "Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs."]. J. Biol. Chem. 265 (28): 17307–17. PMID 2170371.
- Fraser CM, Arakawa S, McCombie WR, Venter JC (1989). [Expression error: Missing operand for > "Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation."]. J. Biol. Chem. 264 (20): 11754–61. PMID 2568356.
- Kobilka BK, Matsui H, Kobilka TS, et al. (1987). [Expression error: Missing operand for > "Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor."]. Science 238 (4827): 650–6. doi:. PMID 2823383.
- Lynch CJ, Steer ML (1981). [Expression error: Missing operand for > "Evidence for high and low affinity alpha 2-receptors. Comparison of [3H]norepinephrine and [3H]phentolamine binding to human platelet membranes."]. J. Biol. Chem. 256 (7): 3298–303. PMID 6259160.
- Eason MG, Moreira SP, Liggett SB (1995). [Expression error: Missing operand for > "Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor."]. J. Biol. Chem. 270 (9): 4681–8. doi:. PMID 7876239.
- Grassie MA, Milligan G (1995). [Expression error: Missing operand for > "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts."]. Biochem. J. 306 ( Pt 2): 525–30. PMID 7887906.
- Shilo L, Sakaue M, Thomas JM, et al. (1994). [Expression error: Missing operand for > "Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene."]. Cell. Signal. 6 (1): 73–82. doi:. PMID 8011430.
- Valet P, Senard JM, Devedjian JC, et al. (1993). [Expression error: Missing operand for > "Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa."]. J. Clin. Invest. 91 (5): 2049–57. doi:. PMID 8098045.
- Alblas J, van Corven EJ, Hordijk PL, et al. (1993). [Expression error: Missing operand for > "Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts."]. J. Biol. Chem. 268 (30): 22235–8. PMID 8226727.
- Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). [Expression error: Missing operand for > "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B."]. J. Biol. Chem. 272 (31): 19099–102. doi:. PMID 9235896.
- Bétuing S, Daviaud D, Pagès C, et al. (1998). [Expression error: Missing operand for > "Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes."]. J. Biol. Chem. 273 (25): 15804–10. doi:. PMID 9624180.
- Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). [Expression error: Missing operand for > "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes."]. J. Biol. Chem. 274 (19): 13462–9. doi:. PMID 10224112.
- Hein L, Altman JD, Kobilka BK (2000). [Expression error: Missing operand for > "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission."]. Nature 402 (6758): 181–4. doi:. PMID 10647009.
- Schaak S, Cussac D, Cayla C, et al. (2000). [Expression error: Missing operand for > "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells."]. Gut 47 (2): 242–50. doi:. PMID 10896916.
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