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definitions - Amniocentesis

amniocentesis (n.)

1.(pregnancy) extraction by centesis of amniotic fluid from a pregnant woman (after the 15th week of pregnancy) to aid in the diagnosis of fetal abnormalities

Amniocentesis (n.)

1.(MeSH)Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.

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synonyms - Amniocentesis

amniocentesis (n.)


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Diagnostic Technic, Obstetrical and Gynecological, Diagnostic Technic, Obstetric and Gynecologic, Diagnostic Technics, Obstetrical and Gynecological, Diagnostic Technics, Obstetric and Gynecologic, Diagnostic Technique, Obstetrical and Gynecological, Diagnostic Technique, Obstetric and Gynecologic, Diagnostic Techniques, Obstetrical and Gynecological, Diagnostic Techniques, Obstetric and Gynecologic, Obstetrical and Gynecological Diagnostic Technic, Obstetrical and Gynecological Diagnostic Technics, Obstetrical and Gynecological Diagnostic Technique, Obstetrical and Gynecological Diagnostic Techniques, Obstetric and Gynecologic Diagnostic Technic, Obstetric and Gynecologic Diagnostic Technics, Obstetric and Gynecologic Diagnostic Technique, Obstetric and Gynecologic Diagnostic Techniques, Technic, Obstetrical and Gynecological Diagnostic, Technic, Obstetric and Gynecologic Diagnostic, Technics, Obstetrical and Gynecological Diagnostic, Technics, Obstetric and Gynecologic Diagnostic, Technique, Obstetrical and Gynecological Diagnostic, Technique, Obstetric and Gynecologic Diagnostic, Techniques, Obstetrical and Gynecological Diagnostic, Techniques, Obstetric and Gynecologic Diagnostic - Laboratory Technics and Procedures, Laboratory Techniques and Procedures - Micropunctures, Punctures - Procedure, Operative Surgical, Surgical Procedures, Operative[Hyper.]

Diagnosis, Preimplantation, Preimplantation Diagnosis - Cytological Technic, Cytological Technics, Cytological Technique, Cytological Techniques, Cytologic Technics, Technic, Cytological, Technics, Cytological, Technique, Cytological, Techniques, Cytological[Analogie]

Amniocentesis (n.) [MeSH]



ICD-9-CM 75.1
MeSH D000649

Amniocentesis (also referred to as amniotic fluid test or AFT) is a medical procedure[1] used in prenatal diagnosis of chromosomal abnormalities and fetal infections,[2] in which a small amount of amniotic fluid, which contains fetal tissues, is sampled from the amnion or amniotic sac surrounding a developing fetus, and the fetal DNA is examined for genetic abnormalities. This process can be used for prenatal sex discernment and hence this procedure has legal restrictions in some gender-biased countries.



Before the start of the procedure, a local anesthetic can be given to the mother in order to relieve the pain felt during the insertion of the needle used to withdraw the fluid. After the local is in effect, a needle is usually inserted through the mother's abdominal wall, then through the wall of the uterus, and finally into the amniotic sac. With the aid of ultrasound-guidance, a physician punctures the sac in an area away from the fetus and extracts approximately 20 ml of amniotic fluid.

If used for prenatal genetic diagnosis, fetal cells are separated from the extracted sample. The cells are grown in a culture medium, then fixed and stained. Under a microscope the chromosomes are examined for abnormalities. The most common abnormalities detected are Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Turner syndrome (monosomy X). In regard to the fetus, the puncture heals and the amniotic sac replenishes the liquid over the next 24–48 hours.[3][4]

  Indications and results

  Genetic diagnosis

Early in pregnancy, amniocentesis used for diagnosis of chromosomal and other fetal problems such as:

  Lung maturity

Amniocentesis can predict fetal lung maturity, which is inversely correlated to the risk of infant respiratory distress syndrome. In pregnancies of greater than 30 weeks, the fetal lung maturity may be tested by sampling the amount of surfactant in the amniotic fluid. Several tests are available that correlate with the production of surfactant. These include the lecithin-sphingomyelin ratio ("L/S ratio"), the presence of phosphatidylglycerol (PG), and more recently, the surfactant/albumin (S/A) ratio. For the L/S ratio, if the result is less than 2:1, the fetal lungs may be surfactant deficient. The presence of PG usually indicates fetal lung maturity. For the S/A ratio, the result is given as mg of surfactant per gm of protein. An S/A ratio <35 indicates immature lungs, between 35-55 is indeterminate, and >55 indicates mature surfactant production(correlates with an L/S ratio of 2.2 or greater).


Amniocentesis can also be used to detect problems such as:

An emerging indication for amniocentesis is in the management of preterm rupture of membranes where measurement of certain amniotic fluid inflammatory markers may be helpful. If amniotic fluid IL-6, a marker of inflammation, is elevated, the fetus is at high risk and delivery should be considered.[7]

  Risks and drawbacks

Amniocentesis is performed between the 15th and 20th week of pregnancy; performing this test earlier may result in fetal injury.[8] The term "early amniocentesis" is sometimes used to describe use of the process between weeks 11 and 13.[9]

Complications of amniocentesis include preterm labor and delivery, respiratory distress, postural deformities, fetal trauma and alloimmunisation of the mother (rhesus disease). Studies from the 1970s originally estimated the risk of amniocentesis-related miscarriage at around 1 in 200 (0.5%).[10] Three more recent studies from 2000-2006 estimated the procedure-related pregnancy loss at 0.6-0.86%. [11] A more recent study (2006) has indicated this may actually be much lower, perhaps as low as 1 in 1,600 (0.06%). [12]. Unlike the previous studies, the number in this study only reflects the loss that resulted from amniocentesis complications and excluded the cases when parents decided for an abortion following the test results.[11] In contrast to amniocentesis, the risk of miscarriage from chorionic villus sampling (CVS) is believed to be approximately 1 in 100, although CVS may be done up to four weeks earlier, and may be preferable if the possibility of genetic defects is thought to be higher.[13]

Amniotic fluid embolism has been described as a possible risk.[14]

  Amniocentesis and stem cells

Recent studies have discovered that amniotic fluid can be a rich source of multipotent mesenchymal, hematopoietic, neural, epithelial, and endothelial stem cells.[15][16][17]

A potential benefit of using amniotic stem cells over those obtained from embryos is that they side-step ethical concerns among pro-life activists by obtaining pluripotent lines of undifferentiated cells without harm to a fetus or destruction of an embryo. These stem cells would also, if used to treat the same individual they came from, sidestep the donor/recipient issue which has so far stymied all attempts to use donor-derived stem cells in therapies.

Artificial heart valves, working tracheas, as well as muscle, fat, bone, heart, neural and liver cells have all been engineered through use of amniotic stem cells[citation needed]. Tissues obtained from amniotic cell lines show promise for patients suffering from congenital diseases/malformations of the heart, liver, lungs, kidneys, and cerebral tissue.[18]

The first amniotic stem cells bank in US is active in Boston, Massachusetts.[19][20][21][22]

  See also


  1. ^ The word amniocentesis itself indicates precisely the procedure in question, Gr. ἀμνίον amníon being the "inner membrane round the foetus" and κέντησις kéntēsis meaning "pricking", i.e. its puncture in order to retrieve some amniotic fluid.
  2. ^ "Diagnostic Tests – Amniocentesis". Harvard Medical School. http://www.health.harvard.edu/diagnostic-tests/amniosentesis.htm. Retrieved 2008-07-15. 
  3. ^ Jeffrey S. Dungan &; Sherman Elias (Last revision 2008). "Prenatal diagnostic testing". Merck manual home health handbook. http://www.merckmanuals.com/home/womens_health_issues/genetic_disorders_detection/prenatal_diagnostic_testing.html#v808991. Retrieved 24 April 2012. 
  4. ^ Ronnee K. Yashon; Michael R. Cummings (23 September 2011). Human Genetics and Society. Cengage Learning. p. 83. ISBN 978-0-538-73321-2. http://books.google.com/books?id=M11NGJ7Qn3YC&pg=PT83. Retrieved 24 April 2012. 
  5. ^ Dungan, Jeffrey S.; Elias, Sherman (November 2008). "Prenatal Diagnostic Testing". The Merck Manuals Online Medical Library. Archived from the original on 4 August 2010. http://www.merck.com/mmhe/sec22/ch256/ch256c.html. Retrieved July 30, 2010. 
  6. ^ Medina, T. M.; Hill, D. A. (2006). "Preterm premature rupture of membranes: Diagnosis and management". American family physician 73 (4): 659–664. PMID 16506709.  edit
  7. ^ Kenyon, Anna P; Abi-Nader, Khalil N; Pandya, Pranav P (2010). "Pre-Term Pre-Labour Rupture of Membranes and the Role of Amniocentesis". Fetal and Maternal Medicine Review 21 (2): 75. DOI:10.1017/S096553951000001X. 
  8. ^ Seeds, JW (2004 Aug). "Diagnostic mid trimester amniocentesis: how safe?". American journal of obstetrics and gynecology 191 (2): 607–15. PMID 15343248. http://www.ncbi.nlm.nih.gov/pubmed/15343248. 
  9. ^ Sundberg K, Bang J, Smidt-Jensen S et al. (September 1997). "Randomised study of risk of fetal loss related to early amniocentesis versus chorionic villus sampling". Lancet 350 (9079): 697–703. DOI:10.1016/S0140-6736(97)02449-5. PMID 9291904. http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(97)02449-5. 
  10. ^ Amniocentesis Risk Overrated?. Webmd.com (2006-11-01). Retrieved on 2011-11-22.
  11. ^ a b [1]. Committee opinion, Society of Obstetricians and Gynaecologists of Canada.
  12. ^ Eddleman, Keith A.; Malone, Fergal D.; Sullivan, Lisa; Dukes, Kim; Berkowitz, Richard L.; Kharbutli, Yara; Porter, T Flint; Luthy, David A. et al. (2006). "Pregnancy loss rates after midtrimester amniocentesis". Obstet Gynecol 108 (5): 1067–72. DOI:10.1097/01.AOG.0000240135.13594.07. PMID 17077226. 
  13. ^ Rhoads, George G.; Jackson, Laird G.; Schlesselman, Sarah E.; De La Cruz, Felix F.; Desnick, Robert J.; Golbus, Mitchell S.; Ledbetter, David H.; Lubs, Herbert A. et al. (1989). "The safety and efficacy of chorionic villus sampling for early prenatal diagnosis of cytogenetic abnormalities". New England Journal of Medicine 320 (10): 609–17. DOI:10.1056/NEJM198903093201001. PMID 2645520. 
  14. ^ Dodgson J, Martin J, Boswell J, Goodall HB, Smith R (May 1987). "Probable amniotic fluid embolism precipitated by amniocentesis and treated by exchange transfusion". Br Med J (Clin Res Ed) 294 (6583): 1322–3. DOI:10.1136/bmj.294.6583.1322. PMC 1246486. PMID 3109636. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1246486. 
  15. ^ Weiss, Rick (2007-01-08). "Scientists See Potential In Amniotic Stem Cells". The Washington Post. http://www.washingtonpost.com/wp-dyn/content/article/2007/01/07/AR2007010700674.html. Retrieved 2010-04-23. 
  16. ^ "Isolation of amniotic stem cell lines with potential for therapy". http://www.nature.com/nbt/journal/v25/n1/abs/nbt1274.html. 
  17. ^ "Stem Cells – BiocellCenter". Archived from the original on 11 January 2010. http://www.biocellcenter.com/en/services_research/stem_cells/. Retrieved 2010-01-11. 
  18. ^ "Stem cells scientific updates – BiocellCenter". Archived from the original on 11 January 2010. http://www.biocellcenter.com/en/services_research/scientific_updates/. Retrieved 2010-01-11. 
  19. ^ "European Biotech Company Biocell Center Opens First united state Facility for Preservation of Amniotic Stem Cells in Medford, Massachusetts | Reuters". 2009-10-22. Archived from the original on 5 January 2010. http://www.reuters.com/article/pressRelease/idUS166682+22-Oct-2009+PRN20091022. Retrieved 2010-01-11. 
  20. ^ "Europe's Biocell Center opens Medford office – Daily Business Update – The Boston Globe". 2009-10-22. Archived from the original on 12 January 2010. http://www.boston.com/business/ticker/2009/10/europes_biocell.html. Retrieved 2010-01-11. 
  21. ^ "The Ticker - BostonHerald.com". http://www.bostonherald.com/business/general/view/20091022the_ticker. Retrieved 2010-01-11. 
  22. ^ "Biocell partner with largest New England's hospital group to preserve amniotic stem cell". Archived from the original on 14 March 2010. http://www.prnewswire.com/news-releases/biocell-center-corporation-partners-with-new-englands-largest-community-based-hospital-network-to-offer-a-unique-service-in-amniotic-fluid-stem-cell-preservation-86848157.html. Retrieved 2010-03-10. 

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