Angiotensin II receptor type 2

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Angiotensin II receptor, type 2

Identifiers

Symbols

AGTR2; AT2; ATGR2; MRX88

External IDs

OMIM: 300034 MGI: 87966 HomoloGene: 20172 IUPHAR: AT₂ GeneCards: AGTR2 Gene

Gene ontology
Molecular function	• rhodopsin-like receptor activity • protein kinase inhibitor activity • receptor activity • angiotensin type II receptor activity • bradykinin receptor activity
Cellular component	• integral to plasma membrane • membrane
Biological process	• angiotensin mediated vasodilation during regulation of blood pressure • brain renin-angiotensin system • apoptosis • G-protein coupled receptor protein signaling pathway • behavior • blood pressure regulation

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
115.22 - 115.22 Mb

Chr X:
20.64 - 20.65 Mb

PubMed search

[1]

[2]

Angiotensin II receptor type 2, also known as the AT₂ receptor or AGTR2, is a human gene.^[1]

Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.^[1]

1 Interactions
2 See also
3 References
4 External links
5 Further reading

Interactions

Angiotensin II receptor type 2 has been shown to interact with MTUS1.^[2]

References

^ ^a ^b "Entrez Gene: AGTR2 angiotensin II receptor, type 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=186.
^ Nouet, Sandrine; Amzallag Nathalie, Li Jian-Mei, Louis Simon, Seitz Isabell, Cui Tai-Xing, Alleaume Anne-Marie, Di Benedetto Mélanie, Boden Christine, Masson Maryline, Strosberg A Donny, Horiuchi Masatsugu, Couraud Pierre-Olivier, Nahmias Clara (Jul. 2004). [Expression error: Missing operand for > "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP"]. J. Biol. Chem. (United States) 279 (28): 28989–97. doi:10.1074/jbc.M403880200. ISSN 0021-9258. PMID 15123706.

External links

"Angiotensin Receptors: AT₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2202.

de Gasparo M, Catt KJ, Inagami T, "et al." (2000). [Expression error: Missing operand for > "International union of pharmacology. XXIII. The angiotensin II receptors"]. Parmacol Rev. 52: 415–472. PMID 10977869.
D'Amore A, Black MJ, Thomas WG (2005). [Expression error: Missing operand for > "The angiotensin II type 2 receptor causes constituative growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy"]. Hypertension 46: 1347–1354. PMID 16286564.
Regitz-Zagrosek V, Neuss M, Warnecke C, et al. (1997). [Expression error: Missing operand for > "Subtype 2 and atypical angiotensin receptors in the human heart."]. Basic Res. Cardiol. 91 Suppl 2: 73–7. PMID 8957548.
Berry C, Touyz R, Dominiczak AF, et al. (2002). [Expression error: Missing operand for > "Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide."]. Am. J. Physiol. Heart Circ. Physiol. 281 (6): H2337–65. PMID 11709400.
Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). [Expression error: Missing operand for > "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor."]. Biochem. Biophys. Res. Commun. 183 (2): 910–6. doi:10.1016/0006-291X(92)90570-B. PMID 1550596.
Hein L, Barsh GS, Pratt RE, et al. (1995). [Expression error: Missing operand for > "Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice."]. Nature 377 (6551): 744–7. doi:10.1038/377744a0. PMID 7477266.
Ichiki T, Labosky PA, Shiota C, et al. (1995). [Expression error: Missing operand for > "Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor."]. Nature 377 (6551): 748–50. doi:10.1038/377748a0. PMID 7477267.
Lazard D, Briend-Sutren MM, Villageois P, et al. (1995). [Expression error: Missing operand for > "Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues."]. Recept. Channels 2 (4): 271–80. PMID 7719706.
Martin MM, Elton TS (1995). [Expression error: Missing operand for > "The sequence and genomic organization of the human type 2 angiotensin II receptor."]. Biochem. Biophys. Res. Commun. 209 (2): 554–62. doi:10.1006/bbrc.1995.1537. PMID 7733925.
Chassagne C, Beatty BG, Meloche S (1995). [Expression error: Missing operand for > "Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization."]. Genomics 25 (2): 601–3. doi:10.1016/0888-7543(95)80072-T. PMID 7790004.
Koike G, Horiuchi M, Yamada T, et al. (1994). [Expression error: Missing operand for > "Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung."]. Biochem. Biophys. Res. Commun. 203 (3): 1842–50. doi:10.1006/bbrc.1994.2402. PMID 7945336.
Martin MM, Su B, Elton TS (1995). [Expression error: Missing operand for > "Molecular cloning of the human angiotensin II type 2 receptor cDNA."]. Biochem. Biophys. Res. Commun. 205 (1): 645–51. doi:10.1006/bbrc.1994.2714. PMID 7999093.
Tsuzuki S, Ichiki T, Nakakubo H, et al. (1994). [Expression error: Missing operand for > "Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor."]. Biochem. Biophys. Res. Commun. 200 (3): 1449–54. doi:10.1006/bbrc.1994.1613. PMID 8185599.
Servant G, Boulay G, Bossé R, et al. (1993). [Expression error: Missing operand for > "Photoaffinity labeling of subtype 2 angiotensin receptor of human myometrium."]. Mol. Pharmacol. 43 (5): 677–83. PMID 8502225.
Yamada T, Horiuchi M, Dzau VJ (1996). [Expression error: Missing operand for > "Angiotensin II type 2 receptor mediates programmed cell death."]. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 156–60. doi:10.1073/pnas.93.1.156. PMID 8552595.
Zhang J, Pratt RE (1996). [Expression error: Missing operand for > "The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus."]. J. Biol. Chem. 271 (25): 15026–33. doi:10.1074/jbc.271.25.15026. PMID 8663053.
Katsuya T, Horiuchi M, Minami S, et al. (1997). [Expression error: Missing operand for > "Genomic organization and polymorphism of human angiotensin II type 2 receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome."]. Mol. Cell. Endocrinol. 127 (2): 221–8. doi:10.1016/S0303-7207(97)04011-2. PMID 9099917.
Akishita M, Ito M, Lehtonen JY, et al. (1999). [Expression error: Missing operand for > "Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth."]. J. Clin. Invest. 103 (1): 63–71. doi:10.1172/JCI5182. PMID 9884335.
Lehtonen JY, Daviet L, Nahmias C, et al. (1999). [Expression error: Missing operand for > "Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis."]. Mol. Endocrinol. 13 (7): 1051–60. doi:10.1210/me.13.7.1051. PMID 10406457.
Knowle D, Ahmed S, Pulakat L (2000). [Expression error: Missing operand for > "Identification of an interaction between the angiotensin II receptor sub-type AT2 and the ErbB3 receptor, a member of the epidermal growth factor receptor family."]. Regul. Pept. 87 (1-3): 73–82. doi:10.1016/S0167-0115(99)00111-1. PMID 10710290.
Hansen JL, Servant G, Baranski TJ, et al. (2000). [Expression error: Missing operand for > "Functional reconstitution of the angiotensin II type 2 receptor and G(i) activation."]. Circ. Res. 87 (9): 753–9. PMID 11055978.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like

Adrenergic	α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182)
Purinergics	Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotonin	(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other	Acetylcholine (M1, M2, M3, M4, M5) · Adrenomedullin · Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bile acid · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Cannabinoid (CB1, CB2) · Chemokine · Cholecystokinin (A, B) · Dopamine (D1, D2, D3, D4, D5) · EBI2 · Endothelin (A, B) · Estrogen · Formyl peptide (1, 2, 3) · Free fatty acid (1, 2, 3, 4) · FSH · Galanin (1, 2, 3) · Gonadotropin-releasing hormone (1, 2) · GHB receptor · Ghrelin · Histamine (H1, H2, H3, H4) · Kisspeptin · Luteinizing hormone/choriogonadotropin · lysophosphatidic acid (1, 2, 3, 4, 5, 6) · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Melatonin (1A, 1B, 1C) · Niacin (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Orexin (1, 2) · Oxytocin · Oxoglutarate · PAF · Prokineticin (1, 2) · Prolactin-releasing peptide · Protease-activated (1, 2, 3, 4) · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · SREB · Succinate · TAAR (1, 2, 3, 5, 6, 8, 9) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Frizzled / Smoothened

Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) · Smoothened

G protein-coupled receptors

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Arabic (ar)	Bulgarian (bg)	Chinese (zh)	Czech (cs)
Danish (da)	Dutch (nl)	English (en)	Estonian (et)
Finnish (fi)	French (fr)	German (de)	Greek (el)
Hungarian (hu)	Italian (it)	Japanese (ja)	Korean (ko)
Norwegian (no)	Polish (pl)	Portuguese (pt)	Romanian (ro)
Russian (ru)	Serbian (sr)	Slovenian (sl)	Spanish (es)
Swedish (sv)	Turkish (tr)	Latvian (lv)	Persian (fa)
Lithuanian (lt)	Icelandic (is)	Slovak (sk)	Croatian (hr)
Hindi (hi)	Vietnamese (vi)	Hebrew (he)	Thai (th)
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Wikipedia

Angiotensin II receptor type 2

From Wikipedia, the free encyclopedia

Contents

Interactions

See also

References

External links

Further reading