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definition - CCR5 DELTA 32

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CCR5-delta 32

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CCR5-delta 32, även skrivet CCR5-Δ32, är en speciellt i norra Europa mer vanlig mutation av en gen (CCR5) som förknippas med resistans eller immunitet mot allvarliga sjukdomar som smittkoppor och HIV. Mutationen tros ha uppkommit för tusentals år sedan men blev mer allmän i Europa under Digerdöden genom att stora delar av befolkningen som saknade mutationen dog. Tidigare hade smittkoppor på samma sätt men mer långsam sett till att göra mutationen relativt vanlig.[1] Detta är dock långt ifrån klarlagt eller allmänt accepterat.[2]

I Skandinavien tros ca 15 % bära på genen i heterozygot form.[3]

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  1. ^ Understanding Genetics
  2. ^ Philip W. Hedrick med Brian C. Verrelli 2006: "'Ground truth' for selection on CCR5-Δ32", Trends in Genetics, vol 22, no 6, sid 293-296
  3. ^ Thurfjell, Karin (2005-03-11). "Pest härdade européer mot HIV". Svenska Dagbladet. http://www.svd.se/nyheter/inrikes/artikel_402979.svd. Läst 2009-05-18. 

 

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