From Wikipedia, the free encyclopedia
Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.[1][2][3]
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.[3]
References
- ^ Myers JC, Howard PS, Jelen AM, Dion AS, Macarak EJ (Aug 1987). [Expression error: Missing operand for > "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes"]. J Biol Chem 262 (19): 9231-8. PMID 2439508.
- ^ Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). [Expression error: Missing operand for > "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13"]. Proc Natl Acad Sci U S A 84 (2): 512-6. PMID 3025878.
- ^ a b "Entrez Gene: COL4A2 collagen, type IV, alpha 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1284.
Further reading
- Hinek A (1995). [Expression error: Missing operand for > "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein."]. Cell Adhes. Commun. 2 (3): 185–93. doi:10.3109/15419069409004436. PMID 7827955.
- Ständer M, Naumann U, Wick W, Weller M (1999). [Expression error: Missing operand for > "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth."]. Cell Tissue Res. 296 (2): 221–7. doi:10.1007/s004410051283. PMID 10382266.
- Kurpakus Wheater M, Kernacki KA, Hazlett LD (1999). [Expression error: Missing operand for > "Corneal cell proteins and ocular surface pathology."]. Biotechnic & histochemistry : official publication of the Biological Stain Commission 74 (3): 146–59. PMID 10416788.
- Kalluri R, Sukhatme VP (2000). [Expression error: Missing operand for > "Fibrosis and angiogenesis."]. Curr. Opin. Nephrol. Hypertens. 9 (4): 413–8. doi:10.1097/00041552-200007000-00013. PMID 10926178.
- Ghebrehiwet B, Peerschke EI, Hong Y, et al. (1992). [Expression error: Missing operand for > "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV."]. J. Leukoc. Biol. 51 (6): 546–56. PMID 1377218.
- Gupta S, Batchu RB, Datta K (1992). [Expression error: Missing operand for > "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface."]. Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.
- Paralkar VM, Nandedkar AK, Pointer RH, et al. (1990). [Expression error: Missing operand for > "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen."]. J. Biol. Chem. 265 (28): 17281–4. PMID 2211625.
- Hernandez MR, Igoe F, Neufeld AH (1986). [Expression error: Missing operand for > "Extracellular matrix of the human optic nerve head."]. Am. J. Ophthalmol. 102 (2): 139–48. doi:10.1016/0002-9394(86)90134-0. PMID 2426947.
- Siebold B, Deutzmann R, Kühn K (1988). [Expression error: Missing operand for > "The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen."]. Eur. J. Biochem. 176 (3): 617–24. doi:10.1111/j.1432-1033.1988.tb14321.x. PMID 2844531.
- Pöschl E, Pollner R, Kühn K (1988). [Expression error: Missing operand for > "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure."]. Embo J. 7 (9): 2687–95. PMID 2846280.
- Murata K, Motayama T, Kotake C (1986). [Expression error: Missing operand for > "Collagen types in various layers of the human aorta and their changes with the atherosclerotic process."]. Atherosclerosis 60 (3): 251–62. doi:10.1016/0021-9150(86)90172-3. PMID 3089234.
- Soininen R, Huotari M, Hostikka SL, et al. (1988). [Expression error: Missing operand for > "The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region."]. J. Biol. Chem. 263 (33): 17217–20. PMID 3182844.
- Hostikka SL, Tryggvason K (1989). [Expression error: Missing operand for > "The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain."]. J. Biol. Chem. 263 (36): 19488–93. PMID 3198637.
- Brazel D, Pollner R, Oberbäumer I, Kühn K (1988). [Expression error: Missing operand for > "Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain."]. Eur. J. Biochem. 172 (1): 35–42. doi:10.1111/j.1432-1033.1988.tb13852.x. PMID 3345760.
- Hostikka SL, Kurkinen M, Tryggvason K (1987). [Expression error: Missing operand for > "Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region."]. FEBS Lett. 216 (2): 281–6. doi:10.1016/0014-5793(87)80706-8. PMID 3582677.
- Killen PD, Francomano CA, Yamada Y, et al. (1988). [Expression error: Missing operand for > "Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2)."]. Hum. Genet. 77 (4): 318–24. doi:10.1007/BF00291418. PMID 3692475.
- Glant TT, Hadházy C, Mikecz K, Sipos A (1985). [Expression error: Missing operand for > "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II."]. Histochemistry 82 (2): 149–58. PMID 3997552.
- Uscanga L, Kennedy RH, Stocker S, et al. (1984). [Expression error: Missing operand for > "Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas."]. Digestion 30 (3): 158–64. doi:10.1159/000199100. PMID 6389236.
| PDB Gallery |
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| 1li1: The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link |
| 1m3d: Structure of Type IV Collagen NC1 Domains |
| 1t60: Crystal structure of Type IV collagen NC1 domain from bovine lens capsule |
| 1t61: crystal structure of collagen IV NC1 domain from placenta basement membrane |
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| Protein: scleroproteins |
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| Extracellular matrix | | 1-12 | type I ( COL1A1, COL1A2) · type II ( COL2A1) · type III · type IV ( COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6) · type V ( COL5A1, COL5A2, COL5A3) · type VI ( COL6A1, COL6A2, COL6A3) · type VII ( COL7A1) · type VIII ( COL8A1, COL8A2) · type IX ( COL9A1, COL9A2, COL9A3) · type X ( COL10A1) · type XI ( COL11A1, COL11A2) · type XII ( COL12A1) | |
13-29 | | |
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Other | |
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| Keratin/Cytokeratin | | type I/chromosome 17 (10, 12, 13, 14, 15, 16, 17, 19, 20) · chromosome 12 (18) · none (21)
type II/chromosome 12 ( 1, 2A, 3, 4, 5, 6A, 6B, 7, 8, 9) | |
| type I/chromosome 17 (31, 32, 33A, 33B, 34, 35, 36, 37, 38)
type II/chromosome 12 ( 81, 82, 83, 84, 85, 86) | |
Ungrouped alpha | chromosome 17 (23, 24, 25, 26, 27, 28, 39, 40)
chromosome 12 ( 71, 72, 73, 74, 75, 76, 77, 78, 79, 80) | |
Not alpha | |
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| Other | | |
see also diseases |
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