CXCL5

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Chemokine (C-X-C motif) ligand 5

Identifiers

Symbols

CXCL5; ENA-78; SCYB5

External IDs

OMIM: 600324 HomoloGene: 88672 GeneCards: CXCL5 Gene

Gene ontology
Molecular function	• chemokine activity
Cellular component	• extracellular region • extracellular space
Biological process	• chemotaxis • inflammatory response • immune response • signal transduction • cell-cell signaling • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_002994

n/a

RefSeq (protein)

NP_002985

n/a

Location (UCSC)

Chr 4:
75.08 - 75.08 Mb

n/a

PubMed search

[1]

n/a

C-X-C motif chemokine 5 is a protein that in humans is encoded by the CXCL5 gene.^[1]^[2]

The protein encoded by this gene, CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha.^[3] Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon IFN-γ.^[4] This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.^[4] The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes.^[3]^[5] CXCL5 has been implicated in connective tissue remodelling.^[4]

References

^ Chang MS, McNinch J, Basu R, Simonet S (Nov 1994). [Expression error: Missing operand for > "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene"]. J Biol Chem 269 (41): 25277-82. PMID 7929219.
^ "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6374.
^ ^a ^b Chang MS, McNinch J, Basu R, Simonet S (1994). "Cloning and characterization of the human neutrophil-activating peptide (ENA-78) gene". J. Biol. Chem. 269 (41): 25277–82. PMID 7929219. http://www.jbc.org/cgi/content/abstract/269/41/25277.
^ ^a ^b ^c Persson T, Monsef N, Andersson P, Bjartell A, Malm J, Calafat J, Egesten A (2003). [Expression error: Missing operand for > "Expression of the neutrophil-activating CXC chemokine ENA-78/CXCL5 by human eosinophils"]. Clin. Exp. Allergy 33 (4): 531–7. doi:10.1046/j.1365-2222.2003.01609.x. PMID 12680872.
^ O'Donovan N, Galvin M, Morgan JG (1999). [Expression error: Missing operand for > "Physical mapping of the CXC chemokine locus on human chromosome 4"]. Cytogenet. Cell Genet. 84 (1-2): 39–42. doi:10.1159/000015209. PMID 10343098.

Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). [Expression error: Missing operand for > "A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5."]. J. Immunol. 179 (7): 4849–56. PMID 17878384.
Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). [Expression error: Missing operand for > "Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease."]. J. Leukoc. Biol. 62 (5): 604–11. PMID 9365115.
Struyf S, Proost P, Van Damme J (2004). [Expression error: Missing operand for > "Regulation of the immune response by the interaction of chemokines and proteases."]. Adv. Immunol. 81: 1–44. doi:10.1016/S0065-2776(03)81001-5. PMID 14711052.
Walz A, Burgener R, Car B, et al. (1992). [Expression error: Missing operand for > "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8."]. J. Exp. Med. 174 (6): 1355–62. doi:10.1084/jem.174.6.1355. PMID 1744577.
Power CA, Furness RB, Brawand C, Wells TN (1995). [Expression error: Missing operand for > "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets."]. Gene 151 (1-2): 333–4. doi:10.1016/0378-1119(94)90682-3. PMID 7828901.
Corbett MS, Schmitt I, Riess O, Walz A (1995). [Expression error: Missing operand for > "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)."]. Biochem. Biophys. Res. Commun. 205 (1): 612–7. doi:10.1006/bbrc.1994.2709. PMID 7999089.
Koch AE, Kunkel SL, Harlow LA, et al. (1994). [Expression error: Missing operand for > "Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis."]. J. Clin. Invest. 94 (3): 1012–8. doi:10.1172/JCI117414. PMID 8083342.
Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). [Expression error: Missing operand for > "Chemokine and chemokine receptor mRNA expression in human platelets."]. Cytokine 7 (6): 479–82. doi:10.1006/cyto.1995.0065. PMID 8580362.
Ahuja SK, Murphy PM (1996). [Expression error: Missing operand for > "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor."]. J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798.
Keates S, Keates AC, Mizoguchi E, et al. (1997). [Expression error: Missing operand for > "Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis."]. Am. J. Physiol. 273 (1 Pt 1): G75–82. PMID 9252512.
Wuyts A, Proost P, Lenaerts JP, et al. (1998). [Expression error: Missing operand for > "Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78."]. Eur. J. Biochem. 255 (1): 67–73. doi:10.1046/j.1432-1327.1998.2550067.x. PMID 9692902.
Wyrick PB, Knight ST, Paul TR, et al. (1999). [Expression error: Missing operand for > "Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis."]. J. Infect. Dis. 179 (4): 954–66. doi:10.1086/314676. PMID 10068592.
Wuyts A, Govaerts C, Struyf S, et al. (1999). [Expression error: Missing operand for > "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."]. Eur. J. Biochem. 260 (2): 421–9. doi:10.1046/j.1432-1327.1999.00166.x. PMID 10095777.
Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). [Expression error: Missing operand for > "Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines."]. Faseb J. 13 (12): 1565–74. PMID 10463948.
Luu NT, Rainger GE, Nash GB (2000). [Expression error: Missing operand for > "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils."]. J. Immunol. 164 (11): 5961–9. PMID 10820279.
Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). [Expression error: Missing operand for > "Control of chemokine production at the blood-retina barrier."]. Immunology 101 (3): 426–33. doi:10.1046/j.0019-2805.2000.01105.x. PMID 11106948.
Zhang C, Thornton MA, Kowalska MA, et al. (2001). [Expression error: Missing operand for > "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."]. Blood 98 (3): 610–7. doi:10.1182/blood.V98.3.610. PMID 11468158.
Chandrasekar B, Melby PC, Sarau HM, et al. (2003). [Expression error: Missing operand for > "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway."]. J. Biol. Chem. 278 (7): 4675–86. doi:10.1074/jbc.M207006200. PMID 12468547.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.

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Cell signaling: cytokines

By family

Interleukin

IL-1 superfamily	1 (1Ra) · 18 · 33
IL-6 like/gp130 using	6 · 11 · 27 · 30 · 31 (+non IL Oncostatin M, Leukemia inhibitory factor, Ciliary neurotrophic factor, Cardiotrophin 1)
IL-10 family	10 · 19 · 20 · 22 · 24 · 26
Interferon type III	28 · 29
Common γ-chain family	2/15 · 3 · 4 · 7 · 9 · 13 · 21
IL-12 family	12 · 23 · 27 · 35
Other	5 · 8 · 14 · 16 · 17/25 (A) · 32 · 34

Chemokine

CCL	1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20 · 21 · 22 · 23 · 24 · 25 · 26 · 27 · 28
CXCL	1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17
CX3CL	1
XCL	1 · 2

TNF

Main	TNF-alpha
TNF (ligand) superfamily	4-1BB ligand · B-cell activating factor · FAS ligand · Lymphotoxin · OX40L · RANKL · TRAIL
Cluster of differentiation	CD70 · CD153 · CD154

Interferon

I	alpha (Pegylated 2a, Pegylated 2b), beta (1a, 1b)
II	Gamma
III	IL-28 · IL-29

Other

Monokine · Lymphokine (Lymphotoxin, Transfer factor) · Growth factor · Hematopoietic (Stem cell factor, Colony-stimulating factor) · Autocrine motility factor · Osteopontin

By function

proinflammatory cytokine (IL-1, TNF-alpha) · T_h1 (interferon-gamma and tumor necrosis factor-beta) T_h2 (interleukin 4, interleukin 5, interleukin 6, interleukin 10, interleukin 13)

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CXCL5

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