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||This article needs additional citations for verification. (August 2008)|
The most important casomorphins from bovine milk are those released from the digestion of β-casein into β-casomorphins, sometimes denoted as BCM followed by a numeral indicating the number of amino acids in the sequence. In cattle, the amount of β-casein - and, hence, the potential release of β-casomorphins - varies between species and breeds. Typically, β-casein comprises about one-third of the casein in milk, or about 12 grams per liter of milk. However, there are at least 13 different variants of the β-casein protein in cattle population, with any one cow producing milk that will contain either one or two of these 13 variants. β-casomorphins are found in cheeses made from bovine milk; their concentrations are higher in mould cheeses (e.g. Brie, Rokpol) than in semi-hard cheeses (e.g. Edam, Gouda and Kasztelan).
Each variant fits into one of two main categories known as A1 and A2. In cattle, A1-type β-caseins have the amino acid histidine at position 67, whereas the A2-type β-caseins have the amino acid proline at position 67. Laboratory experiments show that the casomorphin known as BCM7 is released only from the A1-type β-caseins. The potential release of BCM7 is about 0.4 grams per litre of milk (assuming as above that there are 12g of β-casein per litre).
There is also the potential for release of casomorphins from human milk. However, human BCM7 (Tyr-Pro-Phe-Val-Glu-Pro-Ile) differs from the bovine form (Tyr-Pro-Phe-Pro-Gly-Pro-Ile) at two amino acid positions.
Scientific understanding of the biochemistry and pharmacology of casomorphins is incomplete. A recent scientific review is provided by Kaminski et al. (2007).
Diets that eliminate foods containing casein are promoted at conferences for parents of children with ASD, and some books, web sites, and discussion groups contain testimonials describing benefits in autism-related symptoms, notably social engagement and verbal skills. Studies supporting these claims have had significant flaws, so the data is inadequate to guide treatment recommendations. These ideas were tested using sensitive and specific assays based on a combination of HPLC and mass spectrometry, but these peptides cannot be detected in autistic children's urine. The previous reports of these peptides used less specific assays and were strongly criticised as using unreliable methods that were prone to false positive results. However, proponents continue to argue that these peptides are implicated in a number of medical conditions, including diabetes, heart disease, and symptoms of autism and schizophrenia.
Also known as morphiceptin
(Note: There is also a form of bovine β-Casomorphin 8 that has histidine instead of proline in position 8, depending on whether it is derived from A1 or A2 beta-casein.)