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definition - CatSper4

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CatSper4

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CatSper4
Identifiers
SymbolCATSPER4
External IDsOMIM609121 MGI3043288 HomoloGene18638 IUPHAR: CatSper4 GeneCards: CATSPER4 Gene
Orthologs
SpeciesHumanMouse
Entrez378807329954
EnsemblENSG00000188782ENSMUSG00000048003
UniProtQ7RTX7Q8BVN3
RefSeq (mRNA)NM_198137NM_177866
RefSeq (protein)NP_937770NP_808534
Location (UCSC)Chr 1:
134.33 - 134.38 Mb
Chr 4:
133.77 - 133.78 Mb
PubMed search[1][2]

CatSper4, is a protein which in humans is encoded by the CATSPER4 gene.[1][2][3] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[4]

References

  1. ^ Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). [Expression error: Missing operand for > "Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis"]. Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMID 12932298. 
  2. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). [Expression error: Missing operand for > "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility"]. Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMID 17227845. 
  3. ^ Clapham DE, Garbers DL (December 2005). [Expression error: Missing operand for > "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels"]. Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 
  4. ^ *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyIntroductionForward?familyId=13. 

 

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