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CoumarinCou"ma*rin (k�"mȧ*rĭn), n. [F., fr. coumarou, a tree of Guiana.] (Chem.) The concrete essence of the tonka bean, the fruit of Dipterix (formerly Coumarouna) odorata and consisting essentially of coumarin proper, which is a white crystalline substance, C9H6O2, of vanilla-like odor, regarded as an anhydride of coumaric acid, and used in flavoring. Coumarin in also made artificially.
|Jmol-3D images||Image 1|
|Molar mass||146.14 g mol−1|
|Density||0.935 g/cm3 (20 °C)|
71 °C, 344 K, 160 °F
301 °C, 574 K, 574 °F
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Coumarin ( //; 2H-chromen-2-one) is a fragrant chemical compound in the benzopyrone chemical class, found in many plants, notably in high concentration in the tonka bean (Dipteryx odorata), vanilla grass (Anthoxanthum odoratum), sweet woodruff (Galium odoratum), mullein (Verbascum spp.), sweet grass (Hierochloe odorata), cassia cinnamon (Cinnamomum aromaticum), melilot (Melilotus ssp.), Panicum Clandestinum or 'Deers Tongue' and sweet clover (Fabaceae spp.). The name comes from a French word, coumarou, for the tonka bean. It has a sweet odor, readily recognised as the scent of newly-mown hay, and has been used in perfumes since 1882. Sweet woodruff, sweet grass and sweet clover in particular are named for their sweet smell, which is due to their high content of this substance.
It has been used as an aroma enhancer in pipe tobaccos and certain alcoholic drinks, although in general it is banned as a flavorant food additive, due to concerns about hepatotoxicity coumarin causes in animal models. It's presence in cigarette tobacco led Jeffrey Wigand to contact CBS news to inform the public about Brown & Williamson's foreknowledge that Coumarin was endangering smokers health, but that the company refused to remove it from their product. Dr. Wigand charged, that there was a “form of rat poison” in the tobacco. He held that from a chemist’s point of view, coumarin is an “immediate precursor” to coumadin – which is a rat poison. Dr. Wigand later stated that coumarin itself is dangerous, having been banned by the FDA for addition to human food in 1954, under his later testimony he would repeatedly classify Coumarin as a 'lung specific carcinogen'. Coumarin has a long and chequered history in the field of health science, it's deleterious health effects were first discussed in the peer reviewed The Journal of the American Medical Association.
When it occurs in high concentrations in forage plants, coumarin is a somewhat bitter-tasting appetite suppressant, and is presumed to be produced by plants as a defense chemical to discourage predation.
Although coumarin itself has no anticoagulant properties, it is transformed into the natural anticoagulant dicoumarol by a number of species of fungi. This occurs as the result of the production of 4-hydroxycoumarin, then further (in the presence of naturally occurring formaldehyde) into the actual anticoagulant dicoumarol, a fermentation product and mycotoxin. This substance was responsible for the bleeding disease known historically as "sweet clover disease" in cattle eating moldy sweet clover silage.
Coumarin is used in the pharmaceutical industry as a precursor molecule in the synthesis of a number of synthetic anticoagulant pharmaceuticals similar to dicoumarol, the notable ones being warfarin (tradenamed "Coumadin," not to be confused with coumarin) and some even more potent rodenticides that work by the same anticoagulant mechanism. See 4-hydroxycoumarin and the relevant section of vitamin K antagonists for a discussion and listing of this class of drugs. All of these agents were historically discovered by analyzing sweet clover disease.
Coumarin has clinical medical value by itself, as an edema modifier. Coumarin and other benzopyrones, such as 5,6 benzopyrone, 1,2 benzopyrone, diosmin, and others, are known to stimulate macrophages to degrade extracellular albumen, allowing faster resorption of edematous fluids. Other biological activities that may lead to other medical uses have been suggested, with varying degrees of evidence.
The Pechmann condensation provides another synthesis of coumarin and its derivatives.
Coumarin has appetite-suppressing properties, suggesting one reason for its widespread occurrence in plants, especially grasses and clovers, is because of its effect of reducing the impact of grazing animals on these forages. Although the compound has a pleasant sweet odor and is responsible for the names of sweet clover and sweet grass, these plants are not named for their taste. Coumarin has a bitter taste, and animals will avoid it, if possible.
Coumarin and its derivatives are all considered phenylpropanoids.
4-Phenylcoumarin is the backbone of the neoflavones, a type of neoflavonoids.
Coumarins have shown some evidence of many biological activities, although they are approved for few medical uses as pharmaceuticals. The activity reported for coumarin and coumarins includes anti-HIV, anti-tumor, anti-hypertension, anti-arrhythmia, anti-inflammatory, anti-osteoporosis, antiseptic, and analgesic (pain relief). It is also used in the treatment of asthma. Coumarin has been used in the treatment of lymphedema.
Coumarin is moderately toxic to the liver and kidneys, with a "Median Lethal Dose" (LD50) of 275 mg/kg — low compared to related compounds. Although only somewhat dangerous to humans, coumarin is a potent rodenticide: Rats and other rodents metabolize it largely to 3,4-coumarin epoxide, a toxic compound that can cause internal hemorrhage and death. Humans metabolize it largely to 7-hydroxycoumarin, a compound of lower toxicity. The German Federal Institute for Risk Assessment has established a "tolerable daily intake" (TDI) of 0.1 mg coumarin per kg body weight, but also advises, [if] this level is exceeded for a short time only, there is no threat to health. For example, a person weighing 60 kg (about 132 lbs) would have a TDI of approximately 6.0 mg of coumarin. The OSHA regard Coumarin to be not classifiable as to its carcinogenicity to humans.
European health agencies have warned against consuming high amounts of cassia bark, one of the four species of cinnamon, because of its coumarin content.[not in citation given] According to the German Federal Institute for Risk Assessment (BFR), 1 kg of (cassia) cinnamon powder contains approximately 2.1 to 4.4 g of coumarin. Powdered Cassia Cinnamon weighs 0.56 g/cc; therefore, 1 kg of Cassia Cinnamon powder is equal to 362.29 teaspoons (1000 g divided by 0.56 g/cc multiplied by 0.20288 tsp/cc). This means 1 teaspoon of cinnamon powder contains 5.8 to 12.1 mg of coumarin, which may be above the Tolerable Daily Intake for smaller individuals. However, it is important to note that the BFR only cautions against high daily intakes of foods containing coumarin. Its report specifically states that "Ceylon" cinnamon, Cinnamomum verum, contains 'hardly any' coumarin. Chamomile, a common herbal tea, also contains coumarin.
Coumarin is often found in tobacco products and artificial vanilla substitutes, despite having been banned as a food additive in numerous countries since the mid-20th century. Coumarin was banned as a food additive in the United States in 1954, largely because of hepatotoxicity results in rodents. OSHA considers this compound to be only a lung-specific carcinogen, and "not classifiable as to its carcinogenicity to humans". Coumarin was banned as an adulterant in cigarettes by tobacco companies in 1997, but due to the lack of reporting requirements to the US Department of Health and Human Services it was still being used as a flavoring additive in pipe tobacco. Coumarin is currently listed by the United States Food and Drug Administration (FDA) among "Substances Generally Prohibited From Direct Addition or Use as Human Food", according to 21 CFR 189.130, but some natural additives containing coumarin, such as sweet woodruff (Galium odoratum) due to its coumarin odor, are allowed "in alcoholic beverages only" (21 CFR 172.510). In Europe, such beverages are very popular, for example Maiwein (white wine with woodruff) and Żubrówka (vodka flavoured with bison grass). However, the coumarin content of these drinks is said to cause headaches.
Coumarin is subject to restrictions on its use in perfumery  as some people may become sensitised to it, however the evidence that coumarin can cause an allergic reaction in humans is disputed.
Compounds derived from coumarin are also called coumarins or coumarinoids; this family includes:
Many of the above-stated compounds (to be specific, the 4-hydroxycoumarins, sometimes loosely called coumarins) are used as anticoagulant drugs and/or as rodenticides, which work by the anticoagulant mechanism. They block the regeneration and recycling of vitamin K. These chemicals are sometimes also incorrectly referred to as "coumadins" rather than 4-hydroxycoumarins (Coumadin is a brand name for warfarin).
Some of the 4-hydroxycoumarin anticoagulant class of chemicals are designed to have very high potency and long residence times in the body, and these are used specifically as poison rodenticides. Death occurs after a period of several days to two weeks, usually from internal hemorrhaging.
Vitamin K is a true antidote for poisoning by these antirodenticide 4-hydroxycoumarins such as bromadiolone. Treatment usually comprises a large dose of vitamin K given intravenously immediately, followed by doses in pill form for a period of at least two weeks, though usually three to four, afterwards. Treatment may even continue for several months. If caught early, the prognosis is good, even when large amounts are ingested. In the short term, transfusion with fresh frozen plasma to provide clotting factors, provides time for vitamin K to reverse enzyme poisoning in the liver, and allow new clotting factors to be synthesized there.