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Wikipedia

EMR1

From Wikipedia, the free encyclopedia

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Egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
SymbolsEMR1; TM7LN3
External IDsOMIM600493 MGI106912 HomoloGene1493 IUPHAR: EMR1 GeneCards: EMR1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez201513733
EnsemblENSG00000174837ENSMUSG00000004730
UniProtQ14246Q3S4B0
RefSeq (mRNA)NM_001974NM_010130
RefSeq (protein)NP_001965NP_034260
Location (UCSC)Chr 19:
6.84 - 6.89 Mb
Chr 17:
57.04 - 57.17 Mb
PubMed search[1][2]

EGF-like module-containing mucin-like hormone receptor-like 1 is a protein that in humans is encoded by the EMR1 gene.[1][2][3]

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.[3]

See also

References

  1. ^ Baud V, Chissoe SL, Viegas-Pequignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (Aug 1995). [Expression error: Missing operand for > "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments"]. Genomics 26 (2): 334-44. PMID 7601460. 
  2. ^ McKnight AJ, Gordon S (Mar 1998). [Expression error: Missing operand for > "The EGF-TM7 family: unusual structures at the leukocyte surface"]. J Leukoc Biol 63 (3): 271-80. PMID 9500513. 
  3. ^ a b "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2015. 

Further reading

  • McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). [Expression error: Missing operand for > "Chromosome mapping of the Emr1 gene."]. Mamm. Genome 8 (12): 946. doi:10.1007/s003359900633. PMID 9383301. 
  • Carver EA, Hamann J, Olsen AS, Stubbs L (2000). [Expression error: Missing operand for > "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication."]. Mamm. Genome 10 (10): 1039–40. doi:10.1007/s003359901157. PMID 10501980. 
  • Lin HH, Stacey M, Hamann J, et al. (2000). [Expression error: Missing operand for > "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97."]. Genomics 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

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