» 
Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese
Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese

definitions - Endocytosis

Endocytosis (n.)

1.(MeSH)Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.

   Advertizing ▼

definition (more)

definition of Wikipedia

synonyms - Endocytosis

Endocytosis (n.) (MeSH)

G04.335.487

   Advertizing ▼

phrases

analogical dictionary

Wikipedia

Endocytosis

                   
  Entry of material into the nucleus through endocytosis. The phagosome travels from the cell membrane to the nucleus, and then is engulfed by the nucleus, releasing its contents.

Endocytosis is a process by which cells absorb molecules (such as proteins) by engulfing them. It is used by all cells of the body because most substances important to them are large polar molecules that cannot pass through the hydrophobic plasma or cell membrane. The process which is the opposite to endocytosis is exocytosis. [1]

Contents

  Endocytosis pathways

Endocytosis pathways could be subdivided into four categories: namely, clathrin-mediated endocytosis, caveolae, macropinocytosis, and phagocytosis.[2]

  • Clathrin-mediated endocytosis is mediated by small (approx. 100 nm in diameter) vesicles that have a morphologically characteristic crystalline coat made up of a complex of proteins that are mainly associated with the cytosolic protein clathrin. Clathrin-coated vesicles (CCVs) are found in virtually all cells and form domains of the plasma membrane termed clathrin-coated pits. Coated pits can concentrate large extracellular molecules that have different receptors responsible for the receptor-mediated endocytosis of ligands, e.g. low density lipoprotein, transferrin, growth factors, antibodies and many others.
  • Caveolae are the most common reported non-clathrin-coated plasma membrane buds, which exist on the surface of many, but not all cell types. They consist of the cholesterol-binding protein caveolin (Vip21) with a bilayer enriched in cholesterol and glycolipids. Caveolae are small (approx. 50 nm in diameter) flask-shape pits in the membrane that resemble the shape of a cave (hence the name caveolae). They can constitute up to a third of the plasma membrane area of the cells of some tissues, being especially abundant in smooth muscle, type I pneumocytes, fibroblasts, adipocytes, and endothelial cells.[3] Uptake of extracellular molecules is also believed to be specifically mediated via receptors in caveolae.
  • Macropinocytosis, which usually occurs from highly ruffled regions of the plasma membrane, is the invagination of the cell membrane to form a pocket, which then pinches off into the cell to form a vesicle (0.5–5 µm in diameter) filled with a large volume of extracellular fluid and molecules within it (equivalent to ~100 CCVs). The filling of the pocket occurs in a non-specific manner. The vesicle then travels into the cytosol and fuses with other vesicles such as endosomes and lysosomes.[4]
  • Phagocytosis is the process by which cells bind and internalize particulate matter larger than around 0.75 µm in diameter, such as small-sized dust particles, cell debris, micro-organisms and even apoptotic cells, which only occurs in specialized cells. These processes involve the uptake of larger membrane areas than clathrin-mediated endocytosis and caveolae pathway.

More recent experiments have suggested that these morphological descriptions of endocytic events may be inadequate, and a more appropriate method of classification may be based upon the clathrin-dependence of particular pathways, with multiple subtypes of clathrin-dependent and clathrin-independent endocytosis. Mechanistic insight into non-phagocytic, clathrin-independent endocytosis has been lacking, but a recent study has shown how Graf1 regulates a highly prevalent clathrin-independent endocytic pathway known as the CLIC/GEEC pathway.[5]

  Principal components of endocytic pathway

The endocytic pathway of mammalian cells consists of distinct membrane compartments, which internalize molecules from the plasma membrane and recycle them back to the surface (as in early endosomes and recycling endosomes), or sort them to degradation (as in late endosomes and lysosomes). The principal components of the endocytic pathway are:[2]

  • Early endosomes are the first station of the endocytic pathway. Early endosomes are often located in the periphery of the cell, and receive most types of vesicles coming from the cell surface. They have a characteristic tubulo-vesicular structure (vesicles up to 1 µm in diameter with connected tubules of approx. 50 nm diameter) and a mildly acid pH. They are principally sorting organelles where many ligands dissociate from their receptors in the acid pH of the lumen, and from which many of the receptors recycle to the cell surface (via tubules).[6][7] It is also the site of sorting into transcytotic pathway to late components (via vesicular component, which can form multivesicular bodies (MVB) or endosomal carrier vesicles (ECVs)).
  • Late endosomes receive internalized material en route to lysosomes, usually from early endosomes in the endocytic pathway, from trans-Golgi network (TGN) in the biosynthetic pathway, and from phagosomes in the phagocytic pathway.[8] Late endosomes often contain many membrane vesicles or membrane lamellae and proteins characteristic of lysosomes, including lysosomal membrane glycoproteins and acid hydrolases. They are acidic (approx. pH 5.5), and are part of the trafficking itinerary of mannose-6-phosphate receptors. Late endosomes are thought to mediate a final set of sorting events prior to delivery of material to lysosomes.
  • Lysosomes are the last compartment of the endocytic pathway. They are acidic (approx. pH 4.8) and by EM usually appear as large vacuoles (1-2 µm in diameter) containing electron dense material. They have a high content of lysosomal membrane proteins and active lysosomal hydrolases, but no mannose-6-phosphate receptor. They are generally regarded as the principal hydrolytic compartment of the cell.[9][10] Lysosomes chief function in itself is to break down cellular waste products, fats, carbohydrates, proteins, and other macromolecules into simple compounds. These are then returned to the cytoplasm as new cell-building materials. To accomplish the tasks the lysosomes use some 40 different types of hydrolytic enzymes, all of which are manufactured in the endoplasmic reticulum and modified in the Golgi Apparatus.[11]

It was recently found that an Eisosome serves as a portal of endocytosis in yeast.

  Clathrin-mediated endocytosis

The major route for endocytosis in most cells, and the best-understood, is that mediated by the molecule clathrin. This large protein assists in the formation of a coated pit on the inner surface of the plasma membrane of the cell. This pit then buds into the cell to form a coated vesicle in the cytoplasm of the cell. In so doing, it brings into the cell not only a small area of the surface of the cell but also a small volume of fluid from outside the cell.[12][13][14]

Coats function to deform the donor membrane to produce a vesicle, and they also function in the selection of the vesicle cargo. Coat complexes have been well characterized so far including: coat protein-I (COP-I), COP-II, and clathrin.[15][16] Clathrin coats are involved in two crucial transport steps: (i) receptor-mediated and fluid-phase endocytosis from the plasma membrane to early endosome and (ii) transport from the TGN to endosomes. In endocytosis, the clathrin coat is assembled on the cytoplasmic face of the plasma membrane, forming pits that invaginate to pinch off (scission) and become free CCVs. In cultured cells, the assembly of a CCV takes ~ 1min, and several hundred to a thousand or more can form every minute.[17] The main scaffold component of clathrin coat is the 190 kD protein called clathrin heavy chain (CHC) and the 25 kD protein called clathrin light chain (CLC), which form three-legged trimers, called triskelions.

Vesicles selectively concentrate and exclude certain proteins during formation and are not representative of the membrane as a whole. AP2 adaptors are multisubunit complexes that perform this function at the plasma membrane. The best-understood receptors that are found concentrated in coated vesicles of mammalian cells are the LDL receptor (which removes LDL from circulating blood), the transferrin receptor (which brings ferric ions bound by transferrin into the cell) and certain hormone receptors (such as that for EGF).

At any one moment, about 25% of the plasma membrane of a fibroblast is made up of coated pits. As a coated pit has a life of about a minute before it buds into the cell, a fibroblast takes up its surface by this route about once every 16 minutes. Coated vesicles formed from the plasma membrane have a diameter of about 36 nm and a lifetime measured in a few seconds. Once the coat has been shed, the remaining vesicle fuses with endosomes and proceeds down the endocytic pathway. The actual budding-in process, whereby a pit is converted to a vesicle, is carried out by clathrin assisted by a set of cytoplasmic proteins, which includes dynamin and adaptors such as adaptin.

Coated pits and vesicles were first seen in thin sections of tissue in the electron microscope by Matt Lions and Parker George. The importance of them for the clearance of LDL from blood was discovered by R. G Anderson, Michael S. Brown and Joseph L. Goldstein in 1976. Coated vesicles were first purified by Barbara Pearse, who discovered the clathrin coat molecule.

  See also

  References

  1. ^ Science (New York, N.Y.) 285 (5425): 215–20. July 1999. DOI:10.1126/science.285.5425.215. PMC 2213624. PMID 10398591. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=10398591. Retrieved 2009-06-19. 
  2. ^ a b Marsh, Mark (2001). Endocytosis. Oxford University Press. p. vii. ISBN 978-0-19-963851-2. 
  3. ^ Parton RG, Simons K (March 2007). "The multiple faces of caveolae". Nature Reviews Molecular Cell Biology 8 (3): 185–94. DOI:10.1038/nrm2122. PMID 17318224. 
  4. ^ Falcone S, Cocucci E, Podini P, Kirchhausen T, Clementi E, Meldolesi J (November 2006). "Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events". Journal of Cell Science 119 (Pt 22): 4758–69. DOI:10.1242/jcs.03238. PMID 17077125. 
  5. ^ Lundmark R, Doherty GJ, Howes MT, et al. (November 2008). "The GTPase-Activating Protein GRAF1 Regulates the CLIC/GEEC Endocytic Pathway". Current Biology : CB 18 (22): 1802–8. DOI:10.1016/j.cub.2008.10.044. PMC 2726289. PMID 19036340. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2726289. 
  6. ^ Mellman I (1996). "Endocytosis and molecular sorting". Annual Review of Cell and Developmental Biology 12: 575–625. DOI:10.1146/annurev.cellbio.12.1.575. PMID 8970738. 
  7. ^ Mukherjee S, Ghosh RN, Maxfield FR (July 1997). "Endocytosis". Physiological Reviews 77 (3): 759–803. PMID 9234965. http://physrev.physiology.org/cgi/pmidlookup?view=long&pmid=9234965. Retrieved 2009-06-19. 
  8. ^ Stoorvogel W, Strous GJ, Geuze HJ, Oorschot V, Schwartz AL (May 1991). "Late endosomes derive from early endosomes by maturation". Cell 65 (3): 417–27. DOI:10.1016/0092-8674(91)90459-C. PMID 1850321. 
  9. ^ Gruenberg J, Maxfield FR (August 1995). "Membrane transport in the endocytic pathway". Current Opinion in Cell Biology 7 (4): 552–63. DOI:10.1016/0955-0674(95)80013-1. PMID 7495576. 
  10. ^ Luzio JP, Rous BA, Bright NA, Pryor PR, Mullock BM, Piper RC (May 1, 2000). "Lysosome-endosome fusion and lysosome biogenesis". Journal of Cell Science 113 (9): 1515–24. PMID 10751143. http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=10751143. Retrieved 2009-06-19. 
  11. ^ Weissmann, G. - Studies on Lysosomes,1965)
  12. ^ Benmerah A, Lamaze C (August 2007). "Clathrin-coated pits: vive la différence?". Traffic (Copenhagen, Denmark) 8 (8): 970–82. DOI:10.1111/j.1600-0854.2007.00585.x. PMID 17547704. 
  13. ^ Rappoport JZ (June 2008). "Focusing on clathrin-mediated endocytosis". The Biochemical Journal 412 (3): 415–23. DOI:10.1042/BJ20080474. PMID 18498251. 
  14. ^ Granseth B, Odermatt B, Royle SJ, Lagnado L (December 2007). "Clathrin-mediated endocytosis: the physiological mechanism of vesicle retrieval at hippocampal synapses". The Journal of Physiology 585 (Pt 3): 681–6. DOI:10.1113/jphysiol.2007.139022. PMC 2375507. PMID 17599959. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2375507. 
  15. ^ Robinson MS (March 1997). "Coats and vesicle budding". Trends in Cell Biology 7 (3): 99–102. DOI:10.1016/S0962-8924(96)10048-9. PMID 17708916. 
  16. ^ Glick BS, Malhotra V (December 1998). "The curious status of the Golgi apparatus". Cell 95 (7): 883–9. DOI:10.1016/S0092-8674(00)81713-4. PMID 9875843. 
  17. ^ Gaidarov I, Santini F, Warren RA, Keen JH (May 1999). "Spatial control of coated-pit dynamics in living cells". Nature Cell Biology 1 (1): 1–7. DOI:10.1038/8971. PMID 10559856. 

  External links

   
               

 

All translations of Endocytosis


sensagent's content

  • definitions
  • synonyms
  • antonyms
  • encyclopedia

Dictionary and translator for handheld

⇨ New : sensagent is now available on your handheld

   Advertising ▼

sensagent's office

Shortkey or widget. Free.

Windows Shortkey: sensagent. Free.

Vista Widget : sensagent. Free.

Webmaster Solution

Alexandria

A windows (pop-into) of information (full-content of Sensagent) triggered by double-clicking any word on your webpage. Give contextual explanation and translation from your sites !

Try here  or   get the code

SensagentBox

With a SensagentBox, visitors to your site can access reliable information on over 5 million pages provided by Sensagent.com. Choose the design that fits your site.

Business solution

Improve your site content

Add new content to your site from Sensagent by XML.

Crawl products or adds

Get XML access to reach the best products.

Index images and define metadata

Get XML access to fix the meaning of your metadata.


Please, email us to describe your idea.

WordGame

The English word games are:
○   Anagrams
○   Wildcard, crossword
○   Lettris
○   Boggle.

Lettris

Lettris is a curious tetris-clone game where all the bricks have the same square shape but different content. Each square carries a letter. To make squares disappear and save space for other squares you have to assemble English words (left, right, up, down) from the falling squares.

boggle

Boggle gives you 3 minutes to find as many words (3 letters or more) as you can in a grid of 16 letters. You can also try the grid of 16 letters. Letters must be adjacent and longer words score better. See if you can get into the grid Hall of Fame !

English dictionary
Main references

Most English definitions are provided by WordNet .
English thesaurus is mainly derived from The Integral Dictionary (TID).
English Encyclopedia is licensed by Wikipedia (GNU).

Copyrights

The wordgames anagrams, crossword, Lettris and Boggle are provided by Memodata.
The web service Alexandria is granted from Memodata for the Ebay search.
The SensagentBox are offered by sensAgent.

Translation

Change the target language to find translations.
Tips: browse the semantic fields (see From ideas to words) in two languages to learn more.

last searches on the dictionary :

4099 online visitors

computed in 0.046s

   Advertising ▼

I would like to report:
section :
a spelling or a grammatical mistake
an offensive content(racist, pornographic, injurious, etc.)
a copyright violation
an error
a missing statement
other
please precise:

Advertize

Partnership

Company informations

My account

login

registration

   Advertising ▼

Cellular Processes: Cell Cycle, Meiosis, Cell Division, Exocytosis, Endocytosis, (12.85 USD)

Commercial use of this term

Exocytosis and Endocytosis (Methods in Molecular Biology) (32.43 USD)

Commercial use of this term

NEW Exocytosis And Endocytosis BOOK (Hardback) (158.83 AUD)

Commercial use of this term

Clathrin-Independent Endocytosis of ErbB2 in Human Breast Cancer Cells - Barr, D (69.38 USD)

Commercial use of this term

NEW Exocytosis and Endocytosis by Hardcover Book Free Shipping (162.21 USD)

Commercial use of this term

ENDOCYTOSIS IN PLANTS - JOZEF SAMAJ (HARDCOVER) NEW (198.03 USD)

Commercial use of this term

Endocytosis and Exocytosis NEW by Jenny Lee (159.45 USD)

Commercial use of this term

NEW Endocytosis by Sandra L Schmid Hardcover Book (English) Free Shipping (172.02 USD)

Commercial use of this term

Endocytosis in Plants (2012 Edition) (245.4 USD)

Commercial use of this term

Articles on Cellular Processes, Including: Cell Cycle, Endocytosis, Meiosis, ... (23.4 USD)

Commercial use of this term

ENDOCYTOSIS (9781621 - ALEXANDER SORKIN, ET AL. SANDRA L. SCHMID (HARDCOVER) NEW (161.2 USD)

Commercial use of this term

The Endocytosis of Enamel Matrix Protein Derivatives. (91.76 USD)

Commercial use of this term

Clathrin-Independent Endocytosis of Erbb2 in Human Breast Cancer Cells (82.41 USD)

Commercial use of this term

Endocytosis and Exocytosis (156.26 USD)

Commercial use of this term