Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese
Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese

definitions - Ewing's_sarcoma

Ewing's sarcoma (n.)

1.malignant tumor in bone marrow (usually in the pelvis or in long bones)

   Advertizing ▼

definition (more)

definition of Wikipedia

synonyms - Ewing's_sarcoma

   Advertizing ▼

analogical dictionary


MESH root[Thème]

Ewing's sarcoma [MeSH]


Ewing's sarcoma

Ewing's sarcoma
Classification and external resources

Micrograph of metastatic Ewing sarcoma (right of image) in normal lung (left of image). PAS stain.
ICD-9 170.9
ICD-O: M9260/3
OMIM 133450
DiseasesDB 4604
MedlinePlus 001302
eMedicine ped/2589
MeSH D012512

Ewing's sarcoma is a malignant small, round, blue cell tumour. It is a rare disease in which cancer cells are found in the bone or in soft tissue. The most common areas in which it occurs are the pelvis, the femur, the humerus, the ribs and clavicle.

Because a common genetic locus is responsible for a large percentage of Ewing's sarcoma and primitive neuroectodermal tumors, these are sometimes grouped together in a category known as the Ewing family of tumors.[1] The diseases are, however, considered to be different: peripheral primitive neuroectodermal tumours are generally not associated with bones, while Ewing sarcomas are most commonly related to bone.

Ewing's sarcoma occurs most frequently in teenagers and young adults, with a male/female ratio of 1.6:1.[2]

Although usually classified as a bone tumour, Ewing's sarcoma can have characteristics of both mesodermal and ectodermal origin, making it difficult to classify.[3]

James Ewing (1866–1943) first described the tumour, establishing that the disease was separate from lymphoma and other types of cancer known at that time.[4][5]



Genetic exchange between chromosomes can cause cells to become cancerous. Ewing's sarcoma is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.

EWS/FLI functions as the master regulator.[6]

Other translocations are at t(21;22)[7] and t(7;22).[8]


According to The Bone Cancer Research Trust (BCRT) the most common symptoms reported are: Localised pain: bone pain; may come and go and vary in its intensity. Swelling, this can be seen if it is on a bone near the surface of the body but in other places, like on the pelvis, it may not be visible.[9]

  Clinical findings

  Distribution of Ewing's sarcoma. Most frequent locations are the large long bones and the pelvis.

Ewing's sarcoma is more common in males and usually presents in childhood or early adulthood, with a peak between 10 and 20 years of age. It can occur anywhere in the body, but most commonly in the pelvis and proximal long tubular bones, especially around the growth plates. The diaphyses of the femur are the most common sites, followed by the tibia and the humerus. Thirty percent are overtly metastatic at presentation. Patients usually experience extreme bone pain.

It is positive for CD99 and negative for CD45.[10]

  Imaging findings

  X-Ray of a child with Ewing sarcoma of the tibia.
  Magnetic resonance imaging slice showing Ewing's sarcoma of the left hip (white area shown right).

On conventional radiographs, the most common osseous presentation is a permeative lytic lesion with periosteal reaction. The classic description of lamellated or "onion skin" type periosteal reaction is often associated with this lesion. Plain films add valuable information in the initial evaluation or screening. The wide zone of transition (e.g. permeative) is the most useful plain film characteristic in differentiation of benign versus aggressive or malignant lytic lesions.

MRI should be routinely used in the work-up of malignant tumours. MRI will show the full bony and soft tissue extent and relate the tumour to other nearby anatomic structures (e.g. vessels). Gadolinium contrast is not necessary as it does not give additional information over noncontrast studies, though some current researchers argue that dynamic, contrast enhanced MRI may help determine the amount of necrosis within the tumour, thus help in determining response to treatment prior to surgery.

CT can also be used to define the extraosseous extent of the tumour, especially in the skull, spine, ribs and pelvis. Both CT and MRI can be used to follow response to radiation and/or chemotherapy.

Bone scintigraphy can also be used to follow tumour response to therapy.

In the group of malignant small round cell tumours which include Ewing's sarcoma, bone lymphoma and small cell osteosarcoma, the cortex may appear almost normal radiographically, while there is permeative growth throughout the Haversian channels. These tumours may be accompanied by a large soft tissue mass while there is almost no visible bone destruction. The radiographs frequently do not shown any signs of cortical destruction.

Radiographically Ewing's Sarcoma presents as "Moth-eaten" destructive radiolucencies of the medulla and erosion of the cortex with expansion.

  Clinical differential diagnosis

Other entities that may have a similar clinical presentation include osteomyelitis, osteosarcoma (especially telangiectatic osteosarcoma) and eosinophilic granuloma. Soft tissue neoplasms such as pleomorphic undifferentiated sarcoma (malignant fibrous histiocytoma) that erode into adjacent bone may also have a similar appearance.


  Micrograph of a metastatic Ewing's sarcoma with the characteristic cytoplasmic clearing on H&E staining, which was showing to be PAS positive.

The definitive diagnosis is based on histomorphologic findings, immunohistochemistry and molecular pathology.

Ewing's sarcoma is a small round cell tumor, that typically has a clear cytoplasm on H&E staining, due to glycogen. The presence of the glycogen can be demonstrated with positive PAS staining and negative PAS diastase staining. The characteristic immunostain is CD99 which diffusely marks the cell membrane. Morphologic and immunohistochemical findings are corroborated with an associated chromosomal translocation, of which there are several. The most common translocation, present in approximately 90% of Ewing sarcoma cases, is t(11;22)(q24;q12).[11][12]

The pathologic differential diagnosis is the grouping of Small, round, blue cell tumours, which includes lymphoma, alveolar rhabdomyosarcoma and desmoplastic small round cell tumor, among others.


The frequency in the United States depends on the patient's age, with a rate of 0.3 case per 1,000,000 children in those younger than 3 years of age to as high as 4.6 cases per 1,000,000 in adolescents aged 15–19 years. Internationally the annual incidence rate averages less than 2 cases per 1,000,000 children.[13] In the United Kingdom an average of six children per year are diagnosed, mainly males in early stages of puberty. Due to the prevalence of diagnosis during teenage years, there may possibly be a link between the onset of puberty and the early stages of this disease, although no research is currently being conducted to confirm this hypothesis.


Because almost all patients with apparently localized disease at diagnosis have occult metastatic disease, multidrug chemotherapy (often including ifosfamide and etoposide)[14] as well as local disease control with surgery and/or radiation is indicated in the treatment of all patients.[15]

Treatment often consists of neo-adjuvant chemotherapy generally followed by a limb salvage or an amputation and may also include radiotherapy. Complete excision at the time of biopsy may be performed if malignancy is confirmed at the time it is examined. Treatment lengths vary depending on location and stage of the disease at diagnosis. Radical chemotherapy may be as short as 6 treatments at 3 week cycles, however most patients will undergo chemotherapy for 6–12 months and radiation therapy for 5–8 weeks.

Antisense oligodeoxynucleotides have been proposed as possible treatment by down-regulating the expression of the oncogenic fusion protein associated with the development of Ewing's sarcoma resulting from the EWS-ETS gene translocation.[16][17] In addition, the synthetic retinoid derivative fenretinide (4-hydroxy(phenyl)retinamide) has been reported to induce high levels of cell death in Ewing sarcoma cell lines in vitro and to delay growth of Ewing sarcoma xenografts in vivo mouse models.[18][19]

  Fertility preservation

In women, chemotherapy may damage the ovaries and cause infertility. To avail for future pregnancies, the woman may preserve oocytes or ovarian tissue by oocyte cryopreservation or ovarian tissue cryopreservation prior to starting chemotherapy. However, the latter may reseed the cancer upon reinsertion of the ovarian tissue.[20] If it is performed, the ovarian tissue should be examined for traces of malignancy at both the pathological and molecular levels prior to the grafting of the cryopreserved tissue.[20]


Staging attempts to distinguish patients with localized from those with metastatic disease.[21] Most commonly, metastases occur in the chest, bone and/or bone marrow. Less common sites include the central nervous system and lymph nodes.

Five-year survival for localized disease is 70% to 80% when treated with chemotherapy.[22] Long term survival for metastatic disease can be less than 10% but some sources state it is 25-30%.[23]

  Research, Information and Support

In the UK and Ireland The Bone Cancer Research Trust (BCRT) funds research and provides information on Ewing sarcoma and other bone cancers. This includes information for teenagers who have this condition.


20. Bone Tumors - Differential diagnosis. Henk Jan van der Woude and Robin Smithuis.Radiology department of the Onze Lieve Vrouwe Gasthuis, Amsterdam and the Rijnland hospital,Leiderdorp,the Netherlands.

  1. ^ Iwamoto Y (February 2007). "Diagnosis and treatment of Ewing's sarcoma". Jpn. J. Clin. Oncol. 37 (2): 79–89. DOI:10.1093/jjco/hyl142. PMID 17272319. http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319. 
  2. ^ Burt M, Karpeh M, Ukoha O et al. (January 1993). "Medical tumours of the chest wall. Solitary plasmacytoma and Ewing's sarcoma". J. Thorac. Cardiovasc. Surg. 105 (1): 89–96. PMID 8419714. http://jtcs.ctsnetjournals.org/cgi/content/abstract/105/1/89. 
  3. ^ Longtin R (November 2003). "Ewing sarcoma: a miracle drug waiting to happen?". J. Natl. Cancer Inst. 95 (21): 1574–6. PMID 14600088. http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=14600088. 
  4. ^ synd/2367 at Who Named It?
  5. ^ Ewing, J. (1921). "Diffuse endothelioma of bone". Proceedings of the New York Pathological Society 21: 17–24. 
  6. ^ Owen LA, Kowalewski AA, Lessnick SL (2008). Wu, Xiaolin. ed. "EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma". PLoS ONE 3 (4): e1965. DOI:10.1371/journal.pone.0001965. PMC 2291578. PMID 18414662. http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001965. 
  7. ^ Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT (February 1994). "A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG". Nat. Genet. 6 (2): 146–51. DOI:10.1038/ng0294-146. PMID 8162068. 
  8. ^ Jeon IS, Davis JN, Braun BS et al. (March 1995). "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1". Oncogene 10 (6): 1229–34. PMID 7700648. 
  9. ^ See http://www.bcrt.org.uk/bci_symptoms_of_ewings_sarcoma.php
  10. ^ Bernstein M, Kovar H, Paulussen M et al. (May 2006). "Ewing sarcoma family of tumours: current management". Oncologist 11 (5): 503–19. DOI:10.1634/theoncologist.11-5-503. PMID 16720851. http://theoncologist.alphamedpress.org/cgi/pmidlookup?view=long&pmid=16720851. 
  11. ^ URL: http://atlasgeneticsoncology.org/Tumors/Ewing5010.html. Accessed on: 23 February 2010.
  12. ^ Turc-Carel C, Aurias A, Mugneret F et al. (June 1988). "Chromosomes in Ewing's sarcoma. I. An evaluation of 85 cases of remarkable consistency of t(11;22)(q24;q12)". Cancer Genet. Cytogenet. 32 (2): 229–38. DOI:10.1016/0165-4608(88)90285-3. PMID 3163261. 
  13. ^ Ewing Sarcoma Imaging at eMedicine
  14. ^ Lahl M, Fisher VL, Laschinger K (February 2008). "Ewing sarcoma family of tumours: an overview from diagnosis to survivorship". Clin J Oncol Nurs 12 (1): 89–97. DOI:10.1188/08.CJON.89-97. PMID 18258578. http://ons.metapress.com/openurl.asp?genre=article&doi=10.1188/08.CJON.89-97. 
  15. ^ Randall, RL (2005). "Ewing's Sarcoma Family of Tumours (ESFT)". ESUN. http://sarcomahelp.org/learning_center/ewings_sarcoma.html. Retrieved 2009-04-15. 
  16. ^ Asami S, Chin M, Shichino H et al. (March 2008). "Treatment of Ewing sarcoma using an antisense oligodeoxynucleotide to regulate the cell cycle" (– Scholar search). Biol. Pharm. Bull. 31 (3): 391–4. DOI:10.1248/bpb.31.391. PMID 18310898. http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/31.391?from=PubMed. [dead link]
  17. ^ Mateo-Lozano S, Gokhale PC, Soldatenkov VA, Dritschilo A, Tirado OM, Notario V (November 2006). "Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing sarcoma". Clin. Cancer Res. 12 (22): 6781–90. DOI:10.1158/1078-0432.CCR-06-0609. PMID 17121899. http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17121899. 
  18. ^ Myatt SS, Redfern CP, Burchill SA (April 2005). "p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death". Clin. Cancer Res. 11 (8): 3136–48. DOI:10.1158/1078-0432.CCR-04-2050. PMID 15837770. 
  19. ^ Myatt SS, Burchill SA (February 2008). "The sensitivity of the Ewing's sarcoma family of tumours to fenretinide-induced cell death is increased by EWS-Fli1-dependent modulation of p38(MAPK) activity". Oncogene 27 (7): 985–96. DOI:10.1038/sj.onc.1210705. PMID 17700534. 
  20. ^ a b Abir R, Feinmesser M, Yaniv I et al. (May 2010). "Occasional involvement of the ovary in Ewing sarcoma". Hum Reprod 25 (7): 1708–12. DOI:10.1093/humrep/deq121. PMID 20472912. 
  21. ^ McTiernan AM, Cassoni AM, Driver D, Michelagnoli MP, Kilby AM, Whelan JS (2006). "Improving Outcomes After Relapse in Ewing Sarcoma: Analysis of 114 Patients From a Single Institution". Sarcoma 2006: 83548. DOI:10.1155/SRCM/2006/83548. PMC 1698143. PMID 17496997. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1698143. 
  22. ^ "ACS :: How Is the Ewing Family of Tumors Staged?". http://www.cancer.org/docroot/CRI/content/CRI_2_4_3X_How_is_Ewings_Family_of_tumors_staged_48.asp?sitearea=. 
  23. ^ Thacker, MM; Temple, HT; Scully, SP (2005). "Current treatment for Ewing's sarcoma". Expert review of anticancer therapy 5 (2): 319–31. DOI:10.1586/14737140.5.2.319. PMID 15877528. 

  See also

  External links



All translations of Ewing's_sarcoma

sensagent's content

  • definitions
  • synonyms
  • antonyms
  • encyclopedia

Dictionary and translator for handheld

⇨ New : sensagent is now available on your handheld

   Advertising ▼

sensagent's office

Shortkey or widget. Free.

Windows Shortkey: sensagent. Free.

Vista Widget : sensagent. Free.

Webmaster Solution


A windows (pop-into) of information (full-content of Sensagent) triggered by double-clicking any word on your webpage. Give contextual explanation and translation from your sites !

Try here  or   get the code


With a SensagentBox, visitors to your site can access reliable information on over 5 million pages provided by Sensagent.com. Choose the design that fits your site.

Business solution

Improve your site content

Add new content to your site from Sensagent by XML.

Crawl products or adds

Get XML access to reach the best products.

Index images and define metadata

Get XML access to fix the meaning of your metadata.

Please, email us to describe your idea.


The English word games are:
○   Anagrams
○   Wildcard, crossword
○   Lettris
○   Boggle.


Lettris is a curious tetris-clone game where all the bricks have the same square shape but different content. Each square carries a letter. To make squares disappear and save space for other squares you have to assemble English words (left, right, up, down) from the falling squares.


Boggle gives you 3 minutes to find as many words (3 letters or more) as you can in a grid of 16 letters. You can also try the grid of 16 letters. Letters must be adjacent and longer words score better. See if you can get into the grid Hall of Fame !

English dictionary
Main references

Most English definitions are provided by WordNet .
English thesaurus is mainly derived from The Integral Dictionary (TID).
English Encyclopedia is licensed by Wikipedia (GNU).


The wordgames anagrams, crossword, Lettris and Boggle are provided by Memodata.
The web service Alexandria is granted from Memodata for the Ebay search.
The SensagentBox are offered by sensAgent.


Change the target language to find translations.
Tips: browse the semantic fields (see From ideas to words) in two languages to learn more.

last searches on the dictionary :

1927 online visitors

computed in 0.172s

I would like to report:
section :
a spelling or a grammatical mistake
an offensive content(racist, pornographic, injurious, etc.)
a copyright violation
an error
a missing statement
please precise:



Company informations

My account



   Advertising ▼

Yellow IMPERFECT Bracelets 6 Piece Lot Silicone Wristband Cancer Cause 8" New (6.97 USD)

Commercial use of this term

Autobiography Of A Face Lucy Grealy Book HC Ewing's Sarcoma Child Cancer Story (5.99 USD)

Commercial use of this term

Yellow IMPERFECT Bracelets 50 Piece Lot Silicone Wristband Cancer Cause 8" New (25.97 USD)

Commercial use of this term

Yellow Awareness Ribbon Pin Western Cowboy Boots Hat Spurs Cancer Cause New (11.0 USD)

Commercial use of this term

Yellow Awareness Lapel Pin Ribbon White Dove Cancer Cause Disorder Syndrome New (8.97 USD)

Commercial use of this term

Yellow Awareness Ribbon Lapel Pin Troops Liver Bladder Cancer Cause Pins New (6.27 USD)

Commercial use of this term

Yellow Awareness Lapel Pin Ribbon Motorcycle Cancer Cause Biker Bike Ride New (9.87 USD)

Commercial use of this term

NEW A characterization of NR0B1 in the pathogenesis of Ewing's sarcoma. by Miche (94.32 USD)

Commercial use of this term

Yellow Ribbon White Wine Glass Pin Cancer Cause Awareness Tasting Fund Raising (12.97 USD)

Commercial use of this term

Yellow IMPERFECT Bracelets 100 Piece Lot Silicone Wristband Cancer Cause 8" New (49.97 USD)

Commercial use of this term

Yellow Awareness Ribbon Pin Pitch Your Tent in Land of Hope Camping Camper New (12.97 USD)

Commercial use of this term

Yellow Awareness Pin Walking Legs Ribbon Lapel Liver Bladder Cancer Troops New (10.97 USD)

Commercial use of this term