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definition - Fenethylline

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Fenethylline

                   
Fenethylline
Systematic (IUPAC) name
(RS)-1,3-dimethyl- 7-[2-(1-phenylpropan-2-ylamino)ethyl]purine- 2,6-dione
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status Schedule III (CA) Schedule I (US)
Routes Oral
Identifiers
CAS number 3736-08-1
ATC code N06BA10
PubChem CID 19527
DrugBank DB01482
ChemSpider 18398 YesY
UNII YZ0N7VL5R3 YesY
KEGG D07944 YesY
Chemical data
Formula C18H23N5O2 
Mol. mass 341.408 g/mol
 YesY (what is this?)  (verify)

Fenethylline, also spelled phenethylline, is a synthetic prodrug used as a stimulant and marketed under the brand name Captagon.

Contents

  History

Fenethylline was invented by Degussa AG in 1961[1] and used for around 25 years as a milder alternative to amphetamines. Despite no accepted FDA indication for fenethylline, it was used in applications such as treating "hyperkinetic children" (what would now be referred to as Attention Deficit Hyperactivity Disorder), and also less commonly for treating narcolepsy or as an antidepressant. One of the main advantages of fenethylline was that it does not tend to increase blood pressure to the same extent as amphetamines and so could be used in patients with cardiovascular conditions.

Fenethylline was considered to have fewer side effects and less potential for abuse than amphetamine. Nevertheless, fenethylline was listed in 1981 as a schedule I controlled substance in the US, and it became illegal in most countries in 1986 after being listed by the World Health Organization for international scheduling under the Convention on Psychotropic Substances, even though the actual incidence of fenethylline abuse was quite low.

  Pharmacology

Fenethylline is metabolized by the body to form two drugs amphetamine (24.5% of oral dose) and theophylline (13.7% of oral dose), both of which are active stimulants themselves.[2] The physiological effects of fenethylline therefore result from a combination of all three drugs.[3]

  Abuse

Abuse of fenethylline as the brand Captagon is most common in Arab countries, and counterfeit versions of the legal drug continue to be available despite now being illegal for 20 years. Many of these counterfeit "Captagon" tablets actually contain other amphetamine derivatives that are easier to produce, but are pressed and stamped to look like Captagon pills. Some Captagon pills analyzed do contain fenethylline however, indicating that illicit production of this drug continues to take place.[4]

  References

  1. ^ Fenetylline: therapeutic use, misuse and/or abuse. Kristen G, Schaefer A, von Schlichtegroll A. Drug Alcohol Dependence. 1986 Jun;17(2-3):259-71.
  2. ^ Ellison T, Levy L, Bolger JW, Okun R. The metabolic fate of 3H-fenethylline in man. European Journal of Pharmacology 13:123, 1970.
  3. ^ Chemical characterization of counterfeit captagon tablets seized in Jordan. Alabdalla MA. Forensic Science International. 2005 Sep 10;152(2-3):185-8.
  4. ^ http://edition.cnn.com/2010/WORLD/meast/07/23/middle.east.drugs.amphetamine/index.html?iref=obinsite#fbid=o0wnemVxCdN
   
               

 

All translations of Fenethylline


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