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BoggleFlutoprazepam
From Wikipedia, the free encyclopedia
| Systematic (IUPAC) name | |
|---|---|
| 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one | |
| Identifiers | |
| CAS number | 25967-29-7 |
| ATC code | none |
| PubChem | 3400 |
| Chemical data | |
| Formula | C19H16ClFN2O |
| Mol. mass | 342.795 |
| Pharmacokinetic data | |
| Bioavailability | 80-90% |
| Metabolism | Hepatic |
| Half life | 60-90 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. | X(US) |
| Legal status | Schedule IV(US) |
| Routes | Oral, Intravenous |
Flutoprazepam (Restas, KB-509) is a drug which is a benzodiazepine derivative. It was invented in Japan in 1972, and its medical use remains mostly confined to that country. Its muscle relaxant properties are approximately equivalent to those of diazepam - however, it has more powerful sedative, hypnotic, anxiolytic and anticonvulsant effects and is around four times more potent by weight compared to diazepam. [1] It is longer acting than diazepam due to its long-acting active metabolites,[2] which contribute significantly to its effects.[3]
Flutoprazepam is typically used for the treatment of severe insomnia and may also be used for treating stomach ulcers.[4]
Abuse of benzodiazepines in Japan is extremely common, with flutoprazepam being one of the most commonly abused, along with the benzodiazepines of abuse nimetazepam, temazepam and triazolam.
Flutoprazepam is currently a Schedule IV drug under the international Convention on Psychotropic Substances of 1971.[5][6]
In Singapore, flutoprazepam is a Class C-Schedule II drug under the Misuse of Drugs Act.
In Hong Kong, flutoprazepam is regulated under Schedule 2 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Flutoprazepam may be prescribed for the treatment of insomnia by a registered medical doctor. The penalty for trafficking or manufacturing the substance is a $100,000 (HKD) fine and possibly a short imprisonment (1-2 years). Possession of the substance for consumption without valid prescription from a registered medical doctor is illegal and punishable with a $50,000 (HKD) fine.[7]
See also
References
- ^ Sukamoto, T.; Aikawa, K.; Itoh, K.; Nose, T. (Sep 1980). [Expression error: Missing operand for > "[Psycopharmacological and general pharmacological studies of 7-chloro-1-cyclopropylmethyl-1, 3-dihydro-5-(2-fluorophenyl)-2H-1, 4-benzodiazepin-2-one (KB-509) (author's transl)]"]. Nippon Yakurigaku Zasshi 76 (6): 447–68. PMID 7203280.
- ^ Ueki, S.; Sukamoto, T.; Watanabe, S.; Yamamoto, T.; Kataoka, Y.; Shibata, S.; Suwandi, D.; Shibata, K. et al. (Jul 1982). [Expression error: Missing operand for > "[Behavioral effects of flutoprazepam (KB-509) and its metabolites]"]. Nippon Yakurigaku Zasshi 80 (1): 15–30. PMID 6890927.
- ^ Barzaghi, N.; Leone, L.; Monteleone, M.; Tomasini, G.; Perucca, E. (1989). [Expression error: Missing operand for > "Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects."]. Eur J Drug Metab Pharmacokinet 14 (4): 293–8. PMID 2633923.
- ^ Fukuda, T.; Itoh, K.; Nose, T. (Mar 1981). [Expression error: Missing operand for > "[Antiulcerogenic action of 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (KB-509), a new benzodiazepine derivative]"]. Nippon Yakurigaku Zasshi 77 (3): 273–80. PMID 7052359.
- ^ http://www.cnb.gov.sg/ [Central Narcotics Bureau, Singapore]
- ^ "Green List—List of psychotropic substances under international control" (PDF). International Narcotics Control Board. 23rd edition, August 2003. http://www.incb.org/pdf/e/list/green.pdf. Retrieved 2007-11-25.
- ^ "Bilingual Laws Information System" (English). The Government of the Hong Kong Special Administrative Region of the People's Republic of China. http://www.legislation.gov.hk/eng/index.htm.
