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definitions - Fumaric_acid

fumaric acid (n.)

1.a colorless crystalline acid with a fruity taste; used in making polyester resins

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MESH root[Thème]

fumaric acid [MeSH]


acid[Hyper.]

fumaric acid (n.)


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Wikipedia

Fumaric acid

                   
Fumaric acid
Identifiers
CAS number 110-17-8 YesY
ChemSpider 10197150 YesY
UNII 88XHZ13131 YesY
EC number 203-743-0
DrugBank DB04299
KEGG C00122 YesY
ChEBI CHEBI:18012 YesY
ChEMBL CHEMBL503160 YesY
ATC code D05AX01
Jmol-3D images Image 1
Properties
Molecular formula C4H4O4
Molar mass 116.07 g/mol
Appearance White solid
Density 1.635 g/cm³, solid
Melting point

287 °C

Solubility in water 0.63 g/100 mL
Acidity (pKa) pka1 = 3.03, pka2 = 4.44
Hazards
EU classification Irritant (Xi)
R-phrases R36
S-phrases (S2) S26
NFPA 704
NFPA 704.svg
1
2
0
Related compounds
Related carboxylic acids maleic acid
succinic acid
crotonic acid
Related compounds fumaryl chloride
fumaronitrile
dimethyl fumarate
iron(II) fumarate
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Fumaric acid or trans-butenedioic acid is the chemical compound with the formula HO2CCH=CHCO2H. This white crystalline compound is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid. In fumaric acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z). Fumaric acid has a fruit-like taste. The salts and esters are known as fumarates.

Contents

  Biology

Fumaric acid is found in fumitory (Fumaria officinalis), bolete mushrooms (specifically Boletus fomentarius var. pseudo-igniarius), lichen, and Iceland moss.

Fumarate is an intermediate in the citric acid cycle used by cells to produce energy in the form of adenosine triphosphate (ATP) from food. It is formed by the oxidation of succinate by the enzyme succinate dehydrogenase. Fumarate is then converted by the enzyme fumarase to malate. Human skin naturally produces fumaric acid when exposed to sunlight.[citation needed]

Fumarate is also a product of the urea cycle.

  Medicine

A fumaric acid ester is currently under investigation for treatment of multiple sclerosis.[1]

  Food

As a food additive, it is used as an acidity regulator and is denoted by the E number E297. Fumaric acid is a food acidulent used since 1946. It is non-toxic. It is generally used in beverages and baking powders for which requirements are placed on purity. It is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1.36 g of citric acid to every 0.91 grams of fumaric acid to add sourness, similar to the way malic acid is used. It is also used as a coagulant in stovetop pudding mixes.

It is approved for use as a food additive in the EU[2], USA[3] and Australia and New Zealand[4] (where it is listed by its INS number 297).

  Chemistry

Fumaric acid was first prepared from succinic acid.[5] A traditional synthesis involves oxidation of furfural (from the processing of maize) using chlorate in the presence of a vanadium-based catalyst.[6] Currently, industrial synthesis of fumaric acid is mostly based on catalytic isomerisation of maleic acid in aqueous solutions at low pH. Maleic acid is accessible in large volumes as a hydrolysis product of maleic anhydride, produced by catalytic oxidation of benzene or butane.[7]

The chemical properties of fumaric acid can be anticipated from its component functional groups. This weak acid forms a diester, it undergoes additions across the double bond, and it is an excellent dienophile.

Fumaric acid does not combust in a bomb calorimeter under conditions where maleic acid deflagrates smoothly. For teaching experiments designed to measure the difference in energy between the cis- and trans- isomers, a measured quantity of carbon can be ground with the subject compound and the enthalpy of combustion computed by difference.

  Other uses

Fumaric acid is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes.

  Safety

Fumaric acid converts to the irritant maleic anhydride, upon partial combustion.

  Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [8]

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  Citric_acid_cycle edit

  See also

  References

  1. ^ Moharregh-Khiabani, D.; Linker, R.; Gold, R.; Stangel, M. (2009). "Fumaric Acid and its esters: an emerging treatment for multiple sclerosis". Current neuropharmacology 7 (1): 60–64. DOI:10.2174/157015909787602788. PMC 2724664. PMID 19721818. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2724664.  edit
  2. ^ UK Food Standards Agency: "Current EU approved additives and their E Numbers". http://www.food.gov.uk/safereating/chemsafe/additivesbranch/enumberlist. Retrieved 2011-10-27. 
  3. ^ US Food and Drug Administration: "Listing of Food Additives Status Part II". http://www.fda.gov/Food/FoodIngredientsPackaging/FoodAdditives/ucm191033.htm#ftnT. Retrieved 2011-10-27. 
  4. ^ Australia New Zealand Food Standards Code"Standard 1.2.4 - Labelling of ingredients". http://www.comlaw.gov.au/Details/F2011C00827. Retrieved 2011-10-27. 
  5. ^ Volhard, J. "Darstellung von Maleïnsäureanhydrid" Justus Liebig's Annalen der Chemie 1892, volume 268, page 255-6. doi:10.1002/jlac.18922680108
  6. ^ Milas, N. A. "Fumaric Acid" Organic Synthesis 1943, Collective Volume 2, page 302. Online version
  7. ^ British Patent No. 775,912, publicated on the May 29, 1957, by Monsanto Chemical Company.
  8. ^ The interactive pathway map can be edited at WikiPathways: "TCA_Cycle_WP78". http://www.wikipathways.org/index.php/Pathway:WP78. 

  External links



   
               

 

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