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BoggleHCN1
From Wikipedia, the free encyclopedia
| edit |
| Hyperpolarization activated cyclic nucleotide-gated potassium channel 1 | |||||||||||
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PDB rendering based on 1q3e. | |||||||||||
| Available structures | |||||||||||
| 1q3e, 1q43, 1q5o | |||||||||||
| Identifiers | |||||||||||
| Symbols | HCN1; BCNG-1; BCNG1; HAC-2 | ||||||||||
| External IDs | OMIM: 602780 MGI: 1096392 HomoloGene: 32093 IUPHAR: HCN1 GeneCards: HCN1 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 348980 | 15165 | |||||||||
| Ensembl | ENSG00000164588 | ENSMUSG00000021730 | |||||||||
| UniProt | O60741 | O88704 | |||||||||
| RefSeq (mRNA) | NM_021072 | NM_010408 | |||||||||
| RefSeq (protein) | NP_066550 | NP_034538 | |||||||||
| Location (UCSC) | Chr 5: 45.3 - 45.73 Mb | Chr 13: 118.72 - 119.1 Mb | |||||||||
| PubMed search | [1] | [2] | |||||||||
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.[1][2][3][4]
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM][4]
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Interactions
HCN1 has been shown to interact with HCN2.[5][6]
See also
References
- ^ Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). [Expression error: Missing operand for > "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels"]. Proc Natl Acad Sci U S A 94 (26): 14815–20. PMID 9405696.
- ^ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). [Expression error: Missing operand for > "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain"]. Cell 93 (5): 717–29. PMID 9630217.
- ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). [Expression error: Missing operand for > "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels"]. Pharmacol Rev 57 (4): 455–62. doi:. PMID 16382102.
- ^ a b "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=348980.
- ^ Much, Barbara; Wahl-Schott Christian, Zong Xiangang, Schneider Angela, Baumann Ludwig, Moosmang Sven, Ludwig Andreas, Biel Martin (Oct. 2003). [Expression error: Missing operand for > "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels"]. J. Biol. Chem. (United States) 278 (44): 43781–6. doi:. ISSN 0021-9258. PMID 12928435.
- ^ Proenza, Catherine; Tran Neil, Angoli Damiano, Zahynacz Kristin, Balcar Petr, Accili Eric A (Aug. 2002). [Expression error: Missing operand for > "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels"]. J. Biol. Chem. (United States) 277 (33): 29634–42. doi:. ISSN 0021-9258. PMID 12034718.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). [Expression error: Missing operand for > "Normalization and subtraction: two approaches to facilitate gene discovery."]. Genome Res. 6 (9): 791–806. doi:. PMID 8889548.
- Ludwig A, Zong X, Jeglitsch M, et al. (1998). [Expression error: Missing operand for > "A family of hyperpolarization-activated mammalian cation channels."]. Nature 393 (6685): 587–91. doi:. PMID 9634236.
- Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). [Expression error: Missing operand for > "CCG repeats in cDNAs from human brain."]. Hum. Genet. 103 (6): 666–73. doi:. PMID 9921901.
- Ulens C, Tytgat J (2001). [Expression error: Missing operand for > "Functional heteromerization of HCN1 and HCN2 pacemaker channels."]. J. Biol. Chem. 276 (9): 6069–72. doi:. PMID 11133998.
- Proenza C, Tran N, Angoli D, et al. (2002). [Expression error: Missing operand for > "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels."]. J. Biol. Chem. 277 (33): 29634–42. doi:. PMID 12034718.
- Chaplan SR, Guo HQ, Lee DH, et al. (2003). [Expression error: Missing operand for > "Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain."]. J. Neurosci. 23 (4): 1169–78. PMID 12598605.
- Lesso H, Li RA (2003). [Expression error: Missing operand for > "Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype."]. J. Biol. Chem. 278 (25): 22290–7. doi:. PMID 12668666.
- Bender RA, Soleymani SV, Brewster AL, et al. (2003). [Expression error: Missing operand for > "Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus."]. J. Neurosci. 23 (17): 6826–36. PMID 12890777.
- Much B, Wahl-Schott C, Zong X, et al. (2003). [Expression error: Missing operand for > "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels."]. J. Biol. Chem. 278 (44): 43781–6. doi:. PMID 12928435.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40–5. doi:. PMID 14702039.
External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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