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definitions - Hormone

hormone (n.)

1.the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect

Hormone (n.)

1.(MeSH)Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.

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synonyms - Hormone

Hormone (n.) (MeSH)

Hormones  (MeSH)

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see also - Hormone

hormone (n.)

hormonal

phrases

-Adipokinetic hormone • Adrenocortical hormone • Adrenocorticoid hormone • Adrenocorticotropic hormone • Adrenocorticotropic hormone deficiency • Anti-Müllerian hormone • Anti-Müllerian hormone receptor • Anti-diuretic hormone • Antidiuretic Hormone • Beef hormone controversy • Bioidentical hormone replacement therapy • Corticotropin releasing hormone • Corticotropin releasing hormone antagonist • Corticotropin releasing hormone receptor 1 • Corticotropin releasing hormone receptor 2 • Corticotropin-releasing hormone • Corticotropin-releasing hormone receptor • Counterregulatory hormone • Doctor Hormone • EGF module-containing mucin-like hormone receptor • Female sex hormone • Follicle stimulating hormone • Follicle-stimulating hormone • Follicle-stimulating hormone receptor • Gastrointestinal hormone • Glucagon hormone family • Gonadal hormone • Gonadotropin-releasing hormone • Gonadotropin-releasing hormone agonist • Gonadotropin-releasing hormone analogue • Gonadotropin-releasing hormone antagonist • Gonadotropin-releasing hormone receptor • Growth hormone • Growth hormone 1 • Growth hormone 2 • Growth hormone binding protein • Growth hormone deficiency • Growth hormone receptor • Growth hormone releasing hexapeptide • Growth hormone releasing hormone • Growth hormone releasing hormone receptor • Growth hormone secretagogue receptor • Growth hormone treatment • Hormone (disambiguation) • Hormone Research (journal) • Hormone antagonist • Hormone disruptor • Hormone imbalance • Hormone receptor • Hormone receptor positive tumor • Hormone replacement therapy • Hormone replacement therapy (disambiguation) • Hormone replacement therapy (female-to-male) • Hormone replacement therapy (male-to-female) • Hormone replacement therapy (menopause) • Hormone replacement therapy (trans) • Hormone response element • Hormone responsive element • Hormone therapy • Hormone-sensitive lipase • Human Follicle-Stimulating Hormone • Hypothalamic-pituitary hormone • Juvenile hormone • Juvenile-hormone esterase • Luteinizing hormone • Luteinizing hormone beta polypeptide • Luteinizing hormone/choriogonadotropin receptor • Male sex hormone • Maximum the Hormone • Maximum the Hormone discography • Melanin concentrating hormone • Melanin-concentrating hormone receptor • Melanin-concentrating hormone receptor 1 • Melanin-concentrating hormone receptor 2 • Melanocyte-stimulating hormone • Mullerian inhibiting hormone • Mutant Growth Hormone • Non-tropic hormone • Pancreatic hormone • Parathyroid hormone • Parathyroid hormone receptor • Parathyroid hormone receptor 1 • Parathyroid hormone receptor 2 • Parathyroid hormone-related protein • Peptide hormone • Plant hormone • Prothoracicotropic hormone • Rapid hormone cycling • Releasing hormone • Rooting hormone • Saliva hormone testing • Sex hormone • Sex hormone receptor • Sex hormone-binding globulin • Sex-hormone • Sex-hormone therapy • Steroid hormone • Steroid hormone receptor • Stress hormone • Syndrome of inappropriate antidiuretic hormone hypersecretion • The Hormone Foundation • Thyroid Hormone Receptor-associated Proteins • Thyroid hormone • Thyroid hormone receptor • Thyroid hormone receptor alpha • Thyroid hormone receptor beta • Thyroid hormone resistance • Thyroid-hormone transaminase • Thyroid-stimulating hormone • Thyrotropin-releasing hormone • Thyrotropin-releasing hormone receptor • Tropic hormone

analogical dictionary



hormone (n.)


Wikipedia

Hormone

                   
  Epinephrine (adrenaline), a catecholamine-type hormone

A hormone (from Greek ὁρμή, "impetus") is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. In essence, it is a chemical messenger that transports a signal from one cell to another.[1] All multicellular organisms produce hormones; plant hormones are also called phytohormones. Hormones in animals are often transported in the blood. Cells respond to a hormone when they express a specific receptor for that hormone. The hormone binds to the receptor protein, resulting in the activation of a signal transduction mechanism that ultimately leads to cell type-specific responses.

Endocrine hormone molecules are secreted (released) directly into the bloodstream, whereas exocrine hormones (or ectohormones) are secreted directly into a duct, and, from the duct, they flow either into the bloodstream or from cell to cell by diffusion in a process known as paracrine signalling.

Recently it has been found that a variety of exogenous modern chemical compounds have hormone-like effects on both humans and wildlife. Their interference with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body can change the homeostasis, reproduction, development, and/or behavior, just as endogenously produced hormones do.[2]

Contents

  Hormones as signals

Hormonal signaling involves the following:[citation needed]

  1. Biosynthesis of a particular hormone in a particular tissue
  2. Storage and secretion of the hormone
  3. Transport of the hormone to the target cell(s)
  4. Recognition of the hormone by an associated cell membrane or intracellular receptor protein
  5. Relay and amplification of the received hormonal signal via a signal transduction process: This then leads to a cellular response. The reaction of the target cells may then be recognized by the original hormone-producing cells, leading to a down-regulation in hormone production. This is an example of a homeostatic negative feedback loop.
  6. Degradation of the hormone.

Hormone cells are typically of a specialized cell type, residing within a particular endocrine gland, such as thyroid gland, ovaries, and testes. Hormones exit their cell of origin via exocytosis or another means of membrane transport. The hierarchical model is an oversimplification of the hormonal signaling process. Cellular recipients of a particular hormonal signal may be one of several cell types that reside within a number of different tissues, as is the case for insulin, which triggers a diverse range of systemic physiological effects. Different tissue types may also respond differently to the same hormonal signal. Because of this, hormonal signaling is elaborate and hard to dissect.[citation needed]

  Interactions with receptors

Most hormones initiate a cellular response by initially combining with either a specific intracellular or cell membrane associated receptor protein. A cell may have several different receptors that recognize the same hormone and activate different signal transduction pathways, or a cell may have several different receptors that recognize different hormones and activate the same biochemical pathway.

For many hormones, including most protein hormones, the receptor is membrane-associated and embedded in the plasma membrane at the surface of the cell. The interaction of hormone and receptor typically triggers a cascade of secondary effects within the cytoplasm of the cell, often involving phosphorylation or dephosphorylation of various other cytoplasmic proteins, changes in ion channel permeability, or increased concentrations of intracellular molecules that may act as secondary messengers (e.g., cyclic AMP). Some protein hormones also interact with intracellular receptors located in the cytoplasm or nucleus by an intracrine mechanism.

For hormones such as steroid or thyroid hormones, their receptors are located intracellularly within the cytoplasm of their target cell. To bind their receptors, these hormones must cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, effectively amplifying or suppressing the action of certain genes, and affecting protein synthesis.[3] However, it has been shown that not all steroid receptors are located intracellularly. Some are associated with the plasma membrane.[4]

An important consideration, dictating the level at which cellular signal transduction pathways are activated in response to a hormonal signal, is the effective concentration of hormone-receptor complexes that are formed. Hormone-receptor complex concentrations are effectively determined by three factors:

  1. The number of hormone molecules available for complex formation
  2. The number of receptor molecules available for complex formation
  3. The binding affinity between hormone and receptor.

The number of hormone molecules available for complex formation is usually the key factor in determining the level at which signal transduction pathways are activated, the number of hormone molecules available being determined by the concentration of circulating hormone, which is in turn influenced by the level and rate at which they are secreted by biosynthetic cells. The number of receptors at the cell surface of the receiving cell can also be varied, as can the affinity between the hormone and its receptor.

  Physiology of hormones

Most cells are capable of producing one or more molecules, which act as signaling molecules to other cells, altering their growth, function, or metabolism. The classical hormones produced by cells in the endocrine glands mentioned so far in this article are cellular products, specialized to serve as regulators at the overall organism level. However, they may also exert their effects solely within the tissue in which they are produced and originally released.

The rate of hormone biosynthesis and secretion is often regulated by a homeostatic negative feedback control mechanism. Such a mechanism depends on factors that influence the metabolism and excretion of hormones. Thus, higher hormone concentration alone cannot trigger the negative feedback mechanism. Negative feedback must be triggered by overproduction of an "effect" of the hormone.

Hormone secretion can be stimulated and inhibited by:

  • Other hormones (stimulating- or releasing -hormones)
  • Plasma concentrations of ions or nutrients, as well as binding globulins
  • Neurons and mental activity
  • Environmental changes, e.g., of light or temperature

One special group of hormones is the tropic hormones that stimulate the hormone production of other endocrine glands. For example, thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland, the thyroid, which increases output of thyroid hormones.

A recently identified class of hormones is that of the "hunger hormones" - ghrelin, orexin, and PYY 3-36 - and "satiety hormones" - e.g., cholecystokinin, leptin, nesfatin-1, obestatin.

To release active hormones quickly into the circulation, hormone biosynthetic cells may produce and store biologically inactive hormones in the form of pre- or prohormones. These can then be quickly converted into their active hormone form in response to a particular stimulus.

  Effects of hormones

Hormones have the following effects on the body:

A hormone may also regulate the production and release of other hormones. Hormone signals control the internal environment of the body through homeostasis.

  Chemical classes of hormones

Vertebrate hormones fall into three chemical classes:

  Pharmacology

Many hormones and their analogues are used as medication. The most commonly prescribed hormones are estrogens and progestagens (as methods of hormonal contraception and as HRT), thyroxine (as levothyroxine, for hypothyroidism) and steroids (for autoimmune diseases and several respiratory disorders). Insulin is used by many diabetics. Local preparations for use in otolaryngology often contain pharmacologic equivalents of adrenaline, while steroid and vitamin D creams are used extensively in dermatological practice.

A "pharmacologic dose" of a hormone is a medical usage referring to an amount of a hormone far greater than naturally occurs in a healthy body. The effects of pharmacologic doses of hormones may be different from responses to naturally occurring amounts and may be therapeutically useful. An example is the ability of pharmacologic doses of glucocorticoid to suppress inflammation.

  Important human hormones

See: List of human hormones

  See also

  References

  1. ^ "Hormones". http://www.nlm.nih.gov/medlineplus/hormones.html. 
  2. ^ Crisp TM, Clegg ED, Cooper RL, Wood WP, Anderson DG, Baetcke KP, Hoffmann JL, Morrow MS, Rodier DJ, Schaeffer JE, Touart LW, Zeeman MG, Patel YM (1998). "Environmental endocrine disruption: An effects assessment and analysis". Environ. Health Perspect. 106 (Suppl 1): 11–56. PMC 1533291. PMID 9539004. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1533291. 
  3. ^ Beato M, Chavez S and Truss M (1996). "Transcriptional regulation by steroid hormones". Steroids 61 (4): 240–251. DOI:10.1016/0039-128X(96)00030-X. PMID 8733009. 
  4. ^ Hammes SR (2003). "The further redefining of steroid-mediated signaling". Proc Natl Acad Sci USA 100 (5): 21680–2170. DOI:10.1073/pnas.0530224100. PMC 151311. PMID 12606724. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151311. 

  External links

   
               

 

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