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definitions

Interleukin 4 Receptor (n.)

1.(MeSH)Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4. They are involved in signaling a variety of immunological responses related to allergic INFLAMMATION including the differentiation of TH2 CELLS and the regulation of IMMUNOGLOBULIN E production. Two subtypes of receptors exist and are referred to as the TYPE I INTERLEUKIN-4 RECEPTOR and the TYPE II INTERLEUKIN-4 RECEPTOR. Each receptor subtype is defined by its unique subunit composition.

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Interleukin-4 receptor

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Interleukin 4 receptor

PDB rendering based on 1iar.
Available structures
1iar
Identifiers
SymbolsIL4R; CD124; IL4RA
External IDsOMIM147781 MGI105367 HomoloGene7784 GeneCards: IL4R Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez356616190
EnsemblENSG00000077238ENSMUSG00000030748
UniProtP24394Q3U905
RefSeq (mRNA)NM_000418NM_001008700
RefSeq (protein)NP_000409NP_001008700
Location (UCSC)Chr 16:
27.26 - 27.28 Mb
Chr 7:
125.36 - 125.37 Mb
PubMed search[1][2]

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]

Contents

See also

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.[2][3]

References

  1. ^ "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566. 
  2. ^ Ikizawa, K; Yanagihara Y (Feb. 2000). [Expression error: Missing operand for > "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line"]. Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. ISSN 0006-291X. PMID 10652211. 
  3. ^ Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (Dec. 2001). [Expression error: Missing operand for > "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation"]. J. Immunol. (United States) 167 (11): 6382–7. ISSN 0022-1767. PMID 11714803. 

Further reading

  • Nelms K, Keegan AD, Zamorano J, et al. (1999). [Expression error: Missing operand for > "The IL-4 receptor: signaling mechanisms and biologic functions."]. Annu. Rev. Immunol. 17: 701–38. doi:10.1146/annurev.immunol.17.1.701. PMID 10358772. 
  • Jiang H, Harris MB, Rothman P (2000). [Expression error: Missing operand for > "IL-4/IL-13 signaling beyond JAK/STAT."]. J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136. 

External links

 

All translations of Interleukin-4_receptor


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