JWH-200

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JWH-200
Systematic (IUPAC) name

(1-(2-morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone
Identifiers
CAS number	103610-04-4
ATC code	?
PubChem	10045570
Chemical data
Formula	C₂₅H₂₄N₂O₂
Mol. mass	384.469 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	Legal
Routes	?

JWH-200 is an analgesic chemical from the aminoalkylindole family, which acts as a cannabinoid receptor agonist. Its binding affinity at the CB₁ receptor is 42nM, around the same as that of THC,^[1] but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB₁ binding affinity in vitro,^[2] around 3 times that of THC but with less sedative effect,^[3] most likely reflecting favourable pharmacokinetic characteristics.

References

^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
^ Bell MR, D'Ambra TE, Kumar V, et al. (1991). Antinociceptive (aminoalkyl)indoles. Journal of Medicinal Chemistry. 34 (3): 1099–1110. PMID 1900533
^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (1992). Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057

Cannabinoids

Plant cannabinoids

CBCV • CBD • CBDV • CBGM • CBGV • CBN • CBG • CBV • CBL • THC • THC-C4 • THCV

Cannabinoid metabolites

8,11-DiOH-THC • 11-COOH-THC • 11-OH-THC

Endogenous cannabinoids

Arachidonoyl ethanolamide (Anandamide or AEA) • 2-Arachidonoylglycerol (2-AG) • 2-Arachidonyl glyceryl ether (noladin ether) • Virodhamine • Palmitoylethanolamide (PEA) • N-Arachidonoyl dopamine (NADA) • Oleamide

Synthetic cannabinoid
receptor agonists

Classical cannabinoids (Dibenzopyrans)	A-40174 •A-41988 • A-42574 •Ajulemic acid • AM-087 • AM-411 • AM-855 • AM-905 • AM-906 • AM-919 • AM-938 • AM-4030 • AMG-1 • AMG-3 • AMG-36 • AMG-41 • Dexanabinol (HU-211) • DMHP • Dronabinol • HHC •HU-210 •HU-243 •JWH-051 • JWH-133 • JWH-139 •JWH-229 •JWH-359 • L-759,633 • L-759,656 • Levonantradol (CP 50,5561) • Nabazenil •Nabidrox (Canbisol) •Nabilone • Nabitan • Naboctate •O-806 • O-823 • O-1057 • O-1125 • O-1238 • O-2545 • O-2694 • Parahexyl • Perrottetinene •Pirnabine •THC-O-acetate • THC-O-phosphate
Nonclassical cannabinoids	CP 47,497 • CP 55,244 • CP 55,940 •HU-308 •Nonabine •SPA-229 •Tinabinol •2-Isopropyl-5-methyl-1-(2,6-dihydroxy-4-nonylphenyl)cyclohex-1-ene
Aminoalkylindoles	AM-630 • AM-694 •AM-1241 • JWH-007 •JWH-015 • JWH-018 • JWH-073 • JWH-081 • JWH-122 •JWH-167 •JWH-200 • JWH-203 •JWH-210 •JWH-249 •JWH-250 •JWH-398 •GW-405,833 (L-768,242) •Pravadoline • WIN 55,212-2
Aminoalkylpyrroles	JWH-030 • JWH-147 • JWH-307
Eicosanoids	AM-883 • Arachidonyl-2'-chloroethylamide • Arachidonylcyclopropylamide • Methanandamide • O-585 • O-689 • O-1812 •O-1860 • O-1861
Others	Abnormal cannabidiol • BAY 38-7271 • BAY 59-3074 • CB-13 •GW-842,166X •JWH-171 •O-1918 •O-2220 •Leelamine •Org 28611 •VSN-16

Endocannabinoid
activity enhancers

AM-404 • CAY-10401 •CAY-10402 •JZL184 •N-arachidonoyl-serotonin •O-1624 • PF-622 •PF-750 •PF-3845 •URB-597 • URB-602 •Genistein •Arvanil •Olvanil •Kaempferol •Biochanin A •URB-754

Cannabinoid receptor
antagonists and
inverse agonists

AM-251 • AM-281 • AM-630 • BML-190 •CAY-10508 •CB-25 • CB-52 •Drinabant •Ibipinabant •JTE-907 • LY-320,135 •MK-9470 •NESS-0327 • O-1184 • O-1248 •O-2050 • O-2654 • Org 27569 •Otenabant •Rimonabant • SR-144,528 • Surinabant • Taranabant •VCHSR

This article about a cannabinoid is a stub. You can help Wikipedia by expanding it.

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