KCNC4

From Wikipedia, the free encyclopedia

Jump to: navigation, search

edit

Potassium voltage-gated channel, Shaw-related subfamily, member 4

PDB rendering based on 1b4g.

Available structures

1b4g, 1b4i, 1ztn

Identifiers

Symbols

KCNC4; HKSHIIIC; KSHIIIC; KV3.4; MGC126818

External IDs

OMIM: 176265 MGI: 96670 HomoloGene: 68427 IUPHAR: K_v3.4 GeneCards: KCNC4 Gene

Gene ontology
Molecular function	• ion channel activity • voltage-gated potassium channel activity • protein binding • potassium ion binding
Cellular component	• membrane fraction • voltage-gated potassium channel complex • membrane • integral to membrane
Biological process	• ion transport • potassium ion transport • synaptic transmission

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
110.56 - 110.58 Mb

Chr 3:
107.57 - 107.59 Mb

PubMed search

[1]

[2]

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (KCNC4), also known as K_v3.4, is a human gene.^[1]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.^[1]

References

^ ^a ^b "Entrez Gene: KCNC4 potassium voltage-gated channel, Shaw-related subfamily, member 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3749.

Gutman GA, Chandy KG, Grissmer S, et al. (2006). [Expression error: Missing operand for > "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels."]. Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
Vega-Saenz de Miera E, Moreno H, Fruhling D, et al. (1992). [Expression error: Missing operand for > "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel."]. Proc. Biol. Sci. 248 (1321): 9–18. doi:10.1098/rspb.1992.0036. PMID 1381835.
Ghanshani S, Pak M, McPherson JD, et al. (1992). [Expression error: Missing operand for > "Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1."]. Genomics 12 (2): 190–6. doi:10.1016/0888-7543(92)90365-Y. PMID 1740329.
Rudy B, Sen K, Vega-Saenz de Miera E, et al. (1991). [Expression error: Missing operand for > "Cloning of a human cDNA expressing a high voltage-activating, TEA-sensitive, type-A K+ channel which maps to chromosome 1 band p21."]. J. Neurosci. Res. 29 (3): 401–12. doi:10.1002/jnr.490290316. PMID 1920536.
Covarrubias M, Wei A, Salkoff L, Vyas TB (1995). [Expression error: Missing operand for > "Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate."]. Neuron 13 (6): 1403–12. doi:10.1016/0896-6273(94)90425-1. PMID 7993631.
Beck EJ, Sorensen RG, Slater SJ, Covarrubias M (1998). [Expression error: Missing operand for > "Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action."]. J. Gen. Physiol. 112 (1): 71–84. doi:10.1085/jgp.112.1.71. PMID 9649584.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Angulo E, Noé V, Casadó V, et al. (2005). [Expression error: Missing operand for > "Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease."]. J. Neurochem. 91 (3): 547–57. doi:10.1111/j.1471-4159.2004.02771.x. PMID 15485486.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). [Expression error: Missing operand for > "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."]. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Abbott GW, Butler MH, Goldstein SA (2006). [Expression error: Missing operand for > "Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis."]. Faseb J. 20 (2): 293–301. doi:10.1096/fj.05-5070com. PMID 16449802.
Gregory SG, Barlow KF, McLay KE, et al. (2006). [Expression error: Missing operand for > "The DNA sequence and biological annotation of human chromosome 1."]. Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

PDB Gallery

1b4g: CONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTURAL SWITCHES OF THE INACTIVATION GATE, NMR, 22 STRUCTURES

1b4i: CONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTURAL SWITCHES OF THE INACTIVATION GATE, NMR, 22 STRUCTURES

1ztn: INACTIVATION GATE OF POTASSIUM CHANNEL RAW3, NMR, 8 STRUCTURES

Membrane transport protein: ion channels

Ca²⁺: Calcium channel

Voltage-gated	L-type/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-type/Ca_vα2.2 · P-type/Ca_vα(2.1) · Q-type/Ca_vα2.1 · R-type/Ca_vα2.3 · T-type/Ca_vα(3.1, 3.2, 3.3) α₂δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4) Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)
Ligand-gated	Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)

Na⁺: Sodium channel

Voltage-gated	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)
Constitutively active	Epithelial sodium channel (α, β, γ, δ)

K⁺: Potassium channel

Voltage-gated	K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene
Calcium-activated	BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
Inward-rectifier	K_ir (1.1, 2.1, 2.2, 2.3, 2.4) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
Tandem pore domain	K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other

M⁺: TRP cation channel	TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)
Cl^-: Chloride channel	ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)
Cyclic nucleotide-gated (FC)	α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)
Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family
General	Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel
see also disorders

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Arabic (ar)	Bulgarian (bg)	Chinese (zh)	Czech (cs)
Danish (da)	Dutch (nl)	English (en)	Estonian (et)
Finnish (fi)	French (fr)	German (de)	Greek (el)
Hungarian (hu)	Italian (it)	Japanese (ja)	Korean (ko)
Norwegian (no)	Polish (pl)	Portuguese (pt)	Romanian (ro)
Russian (ru)	Serbian (sr)	Slovenian (sl)	Spanish (es)
Swedish (sv)	Turkish (tr)	Latvian (lv)	Persian (fa)
Lithuanian (lt)	Icelandic (is)	Slovak (sk)	Croatian (hr)
Hindi (hi)	Vietnamese (vi)	Hebrew (he)	Thai (th)
Indonesian (id)

Arabic (ar)	Bulgarian (bg)	Chinese (zh)	Czech (cs)
Danish (da)	Dutch (nl)	English (en)	Estonian (et)
Finnish (fi)	French (fr)	German (de)	Greek (el)
Hungarian (hu)	Italian (it)	Japanese (ja)	Korean (ko)
Norwegian (no)	Polish (pl)	Portuguese (pt)	Romanian (ro)
Russian (ru)	Serbian (sr)	Slovenian (sl)	Spanish (es)
Swedish (sv)	Turkish (tr)	Latvian (lv)	Persian (fa)
Lithuanian (lt)	Icelandic (is)	Slovak (sk)	Croatian (hr)
Hindi (hi)	Vietnamese (vi)	Hebrew (he)	Thai (th)
Indonesian (id)

Wikipedia

KCNC4

From Wikipedia, the free encyclopedia

See also

References

Further reading