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Wikipedia

Lanosterol 14 alpha-demethylase

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cytochrome P450, family 51, subfamily A, polypeptide 1
Identifiers
SymbolCYP51A1
Alt. symbolsCYP51, P45014DM
Entrez1595
HUGO2649
OMIM601637
RefSeqNM_000786
UniProtQ16850
Other data
EC number1.14.13.70
LocusChr. 7 q21.2-21.3

CYP51A1 (or lanosterol 14 alpha-demethylase, P45014DM) is a cytochrome P450 (family 51, subfamily A, polypeptide 1) which converts lanosterol to cholesterol.

It is a target for antifungal drugs, inhibiting the production of ergosterol. Over-expression of CYP51A1 can lead to resistance to these antifungals.[1]

See also

References

  1. Vanden Bossche H, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D (1998). [Expression error: Missing operand for > "Antifungal drug resistance in pathogenic fungi"]. Med. Mycol. 36 Suppl 1: 119–28. PMID 9988500. 

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All translations of Lanosterol_14_alpha-demethylase


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