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definition - Latent_TGF-beta_binding_protein

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Latent TGF-beta binding protein

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The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.[1][2]

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

latent transforming growth factor beta binding protein 1
Identifiers
SymbolLTBP1
Alt. symbolsTGF-beta1-BP-1
Entrez4052
HUGO6714
OMIM150390
RefSeqNM_206943
UniProtQ14766
Other data
LocusChr. 2 p22-p21
latent transforming growth factor beta binding protein 2
Identifiers
SymbolLTBP2
Alt. symbolsLTBP3, C14orf141
Entrez4053
HUGO6715
OMIM602091
RefSeqNM_000428
UniProtQ14767
Other data
LocusChr. 14 q24.3
latent transforming growth factor beta binding protein 3
Identifiers
SymbolLTBP3
Alt. symbolsLTBP2
Entrez4054
HUGO6716
OMIM602090
RefSeqNM_021070
UniProtQ9NS15
Other data
LocusChr. 11 q12
latent transforming growth factor beta binding protein 4
Identifiers
SymbolLTBP4
Alt. symbolsLTBP-4, LTBP-4L
Entrez8425
HUGO6717
OMIM604710
RefSeqNM_003573
UniProtQ8N2S1
Other data
LocusChr. 19 q13.1-13.2

References

  1. Rifkin DB (March 2005). [Expression error: Missing operand for > "Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability"]. J. Biol. Chem. 280 (9): 7409–12. doi:10.1074/jbc.R400029200. PMID 15611103. 
  2. Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB (January 2005). [Expression error: Missing operand for > "Latent TGF-beta binding proteins"]. Int. J. Biochem. Cell Biol. 37 (1): 38–41. doi:10.1016/j.biocel.2004.03.011. PMID 15381147. 

External links

 

All translations of Latent_TGF-beta_binding_protein


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