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Wikipedia

MAPK4

From Wikipedia, the free encyclopedia

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Mitogen-activated protein kinase 4
Identifiers
SymbolsMAPK4; ERK3; Erk4; PRKM4; p63MAPK
External IDsOMIM: 176949 MGI: 2444559 HomoloGene: 2058 GeneCards: MAPK4 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5596225724
EnsemblENSG00000141639ENSMUSG00000024558
UniProtP31152Q3TZE1
RefSeq (mRNA)NM_002747NM_172632
RefSeq (protein)NP_002738NP_766220
Location (UCSC)Chr 18:
46.34 - 46.51 Mb		Chr 18:
74.05 - 74.19 Mb
PubMed search[1][2]

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.[1][2]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.[2]

References

  1. ^ Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). [Expression error: Missing operand for > "Genomic loci of human mitogen-activated protein kinases"]. Oncogene 9 (2): 647-9. PMID 8290275. 
  2. ^ a b "Entrez Gene: MAPK4 mitogen-activated protein kinase 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5596. 

Further reading

  • Seger R, Krebs EG (1995). [Expression error: Missing operand for > "The MAPK signaling cascade."]. Faseb J. 9 (9): 726–35. PMID 7601337. 
  • Davis RJ (1996). [Expression error: Missing operand for > "Transcriptional regulation by MAP kinases."]. Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977. 
  • Robinson MJ, Cobb MH (1997). [Expression error: Missing operand for > "Mitogen-activated protein kinase pathways."]. Curr. Opin. Cell Biol. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID 9069255. 
  • Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). [Expression error: Missing operand for > "Heterogeneous expression of four MAP kinase isoforms in human tissues."]. FEBS Lett. 304 (2-3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID 1319925. 
  • Zhu AX, Zhao Y, Moller DE, Flier JS (1994). [Expression error: Missing operand for > "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3."]. Mol. Cell. Biol. 14 (12): 8202–11. PMID 7969157. 
  • Kinet S, Bernard F, Mongellaz C, et al. (2002). [Expression error: Missing operand for > "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes."]. Blood 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sun M, Wei Y, Yao L, et al. (2006). [Expression error: Missing operand for > "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3."]. Biochem. Biophys. Res. Commun. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641. 
  • Kant S, Schumacher S, Singh MK, et al. (2007). [Expression error: Missing operand for > "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5."]. J. Biol. Chem. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613. 
This article on a gene on chromosome 18 is a stub. You can help Wikipedia by expanding it.

 

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