1.(physiology) a shortening or tensing of a part or organ (especially of a muscle or muscle fiber)
1.(MeSH)A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.;The quality of affecting MUSCLE contractility, positively or negatively.
definition of Wikipedia
Musculoskeletal Physiology, Physiology, Musculoskeletal - Examination, Physical, Physical Examination, Physical Examinations and Diagnoses - Musculoskeletal Physiologic Phenomena, Musculoskeletal Physiologic Phenomenon - Cytoplasmic Filaments, Cytoskeletal Filaments, Cytoskeleton, Microtrabecular Lattice - Muscle Fibers, Myocytes, Skeletal, Myotubes, Skeletal Myocytes[Hyper.]
Muscle Contraction (n.) [MeSH]
action de (ou fait d'être) (fr)[Classe...]
shorten - press, pressing, pressure, tension - compressing, compression - contracture - contraction, cramp, muscle contraction, muscular contraction - constriction - boa constrictor, constrictor - air-pump, compressor - contractile organ, contractor - compression, condensation, contraction - compressible - compressible, squeezable - physiologist - physiologic, physiological[Dérivé]
muscle contraction (n.)
||It has been suggested that Sliding filament model be merged into this article or section. (Discuss) Proposed since February 2011.|
Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten, or remain the same. Although the term contraction implies shortening, when referring to the muscular system, it means muscle fibers generating tension with the help of motor neurons (the terms twitch tension, twitch force, and fiber contraction are also used).
Voluntary muscle contraction is controlled by the central nervous system. The brain sends signals, in the form of action potentials, through the nervous system to the motor neuron that innervates several muscle fibers. In the case of some reflexes, the signal to contract can originate in the spinal cord through a feedback loop with the grey matter. Involuntary muscles such as the heart or smooth muscles in the gut and vascular system contract as a result of non-conscious brain activity or stimuli proceeding in the body to the muscle itself.
|This section does not cite any references or sources. (August 2009)|
For voluntary muscles, all contraction (excluding reflexes) occurs as a result of conscious effort originating in the brain. The brain sends signals, in the form of action potentials, through the nervous system to the motor neuron that innervates several muscle fibers. In the case of some reflexes, the signal to contract can originate in the spinal cord through a feedback loop with the grey matter. Involuntary muscles such as the heart or smooth muscles in the gut and vascular system contract as a result of non-conscious brain activity or stimuli endogenous to the muscle itself. Other actions such as locomotion, breathing, and chewing have a reflex aspect to them: the contractions can be initiated consciously or unconsciously.
There are three general types of muscle tissues:
Skeletal and cardiac muscles are called striated muscle because of their striped appearance under a microscope, which is due to the highly organized alternating pattern of A band and I band.
While nerve impulse profiles are, for the most part, always the same, skeletal muscles are able to produce varying levels of contractile force. This phenomenon can be best explained by Force Summation. Force Summation describes the addition of individual twitch contractions to increase the intensity of overall muscle contraction. This can be achieved in two ways: by increasing the number and size of contractile units simultaneously, called multiple fiber summation, and by increasing the frequency at which action potentials are sent to muscle fibers, called frequency summation.
The calcium ions leave the troponin molecule in order to maintain the calcium ion concentration in the sarcoplasm. The active pumping of calcium ions into the sarcoplasmic reticulum creates a deficiency in the fluid around the myofibrils. This causes the removal of calcium ions from the troponin. Thus, the tropomyosin-troponin complex again covers the binding sites on the actin filaments and contraction ceases.
Skeletal muscle contractions can be broadly separated into twitch and tetanic contractions. In a twitch contraction, a short burst of stimulation causes the muscle to contract, but the duration is so short that the muscle begins relaxing before reaching peak force. The shape of the graph of force vs time in a twitch contraction can give information about the relative rates of calcium release and re-uptake from the sarcoplasmic reticulum. If the stimulation is long enough, the muscle reaches peak force and plateaus at this level, resulting in a tetanic contraction. If the stimulation is not intense enough, force will oscilate during the plateau and be submaximal, but with sufficient stimulation, there will be a constant force level until stimulation stops.
Voluntary muscular contractions can be further classified according to either length changes or force levels. In spite of the fact that the muscle actually shortens only in concentric contractions, all are typically referred to as "contractions".
In reality, muscles rarely perform under any sort of constant force, velocity, or speed, but these contractions are useful for understanding overall muscle properties present in more complex contractions that occur in vivo. Cyclic in vivo contractions can be modeled using work loops.
The interaction of sliding actin and myosin filaments is similar in smooth muscle. There are differences in the proteins involved in contraction in vertebrate smooth muscle compared to cardiac and skeletal muscle. Smooth muscle does not contain troponin, but does contain the thin filament protein tropomyosin and other notable proteins – caldesmon and calponin. Contractions are initiated by the calcium-activated phosphorylation of myosin rather than calcium binding to troponin. Contractions in vertebrate smooth muscle are initiated by agents that increase intracellular calcium. This is a process of depolarizing the sarcolemma and extracellular calcium entering through L-type calcium channels, and intracellular calcium release predominately from the sarcoplasmic reticulum. Calcium release from the sarcoplasmic reticulum is from Ryanodine receptor channels (calcium sparks) by a redox process and Inositol triphosphate receptor channels by the second messenger inositol triphosphate. The intracellular calcium binds with calmodulin, which then binds and activates myosin light-chain kinase. The calcium-calmodulin-myosin light-chain kinase complex phosphorylates myosin on the 20 kilodalton (kDa) myosin light chains on amino acid residue-serine 19, initiating contraction and activating the myosin ATPase. The phosphorylation of caldesmon and calponin by various kinases is suspected to play a role in smooth muscle contraction.
Phosphorylation of the 20 kDa myosin light chains correlates well with the shortening velocity of smooth muscle. During this period, there is a rapid burst of energy utilization as measured by oxygen consumption. Within a few minutes of initiation, the calcium level markedly decreases, the 20 kDa myosin light chains' phosphorylation decreases, and energy utilization decreases; however, force in tonic smooth muscle is maintained. During contraction of muscle, rapidly cycling crossbridges form between activated actin and phosphorylated myosin, generating force. It is hypothesized that the maintenance of force results from dephosphorylated "latch-bridges" that slowly cycle and maintain force. A number of kinases such as Rho kinase, Zip kinase, and Protein Kinase C are believed to participate in the sustained phase of contraction, and calcium flux may be significant.
In invertebrate smooth muscle, contraction is initiated with calcium directly binding to myosin and then rapidly cycling cross-bridges generating force. Similar to vertebrate tonic smooth muscle, there is a low calcium and low energy utilization catch phase. This sustained phase or catch phase has been attributed to a catch protein that is similar to myosin light-chain kinase and titin, called twitchin.
A concentric contraction is a type of muscle contraction in which the muscles shorten while generating force.
During a concentric contraction, a muscle is stimulated to contract according to the sliding filament mechanism. This occurs throughout the length of the muscle, generating force at the musculo-tendinous junction, causing the muscle to shorten and changing the angle of the joint. In relation to the elbow, a concentric contraction of the biceps would cause the arm to bend at the elbow as the hand moved from near to the leg to close to the shoulder (a biceps curl). A concentric contraction of the triceps would change the angle of the joint in the opposite direction, straightening the arm and moving the hand towards the leg.
During an eccentric contraction, the muscle elongates while under tension due to an opposing force being greater than the force generated by the muscle. Rather than working to pull a joint in the direction of the muscle contraction, the muscle acts to decelerate the joint at the end of a movement or otherwise control the repositioning of a load. This can occur involuntarily (when attempting to move a weight too heavy for the muscle to lift) or voluntarily (when the muscle is 'smoothing out' a movement). Over the short-term, strength training involving both eccentric and concentric contractions appear to increase muscular strength more than training with concentric contractions alone.
During an eccentric contraction of the biceps muscle, the elbow starts the movement while bent and then straightens as the hand moves away from the shoulder. During an eccentric contraction of the triceps muscle, the elbow starts the movement straight and then bends as the hand moves towards the shoulder. Desmin, titin, and other z-line proteins are involved in eccentric contractions, but their mechanism is poorly understood in comparison to cross-bridge cycling in concentric contractions.
Muscles undergoing heavy eccentric loading suffer greater damage when overloaded (such as during muscle building or strength training exercise) as compared to concentric loading. When eccentric contractions are used in weight training, they are normally called negatives. During a concentric contraction, muscle fibers slide across each other, pulling the Z-lines together. During an eccentric contraction, the filaments slide past each other the opposite way, though the actual movement of the myosin heads during an eccentric contraction is not known. Exercise featuring a heavy eccentric load can actually support a greater weight (muscles are approximately 40% stronger during eccentric contractions than during concentric contractions) and also results in greater muscular damage and delayed onset muscle soreness one to two days after training. Exercise that incorporates both eccentric and concentric muscular contractions (i.e. involving a strong contraction and a controlled lowering of the weight) can produce greater gains in strength than concentric contractions alone. While unaccustomed heavy eccentric contractions can easily lead to overtraining, moderate training may confer protection against injury.
Eccentric contractions normally occur as a braking force in opposition to a concentric contraction to protect joints from damage. During virtually any routine movement, eccentric contractions assist in keeping motions smooth, but can also slow rapid movements such as a punch or throw. Part of training for rapid movements such as pitching during baseball involves reducing eccentric braking allowing a greater power to be developed throughout the movement.
An isometric contraction of a muscle generates force without changing length. An example can be found when the muscles of the hand and forearm grip an object; the joints of the hand do not move, but muscles generate sufficient force to prevent the object from being dropped.
Unlike mechanical systems such as motors, the force a muscle can generate depends upon both the length and shortening velocity of the muscle.
Force-length relationship, also called the length-tension curve, relates the strength of an isometric contraction to the length of the muscle at which the contraction occurs. Muscles operate with greatest active force when close to an ideal length (often their resting length). When stretched or shortened beyond this (whether due to the action of the muscle itself or by an outside force), the maximum active force generated decreases. This decrease is minimal for small deviations, but the force drops off rapidly as the length deviates further from the ideal. As a result, in most biological systems, the range of muscle contraction will remain on the peak of the length-tension curve, in order to maximize contraction force (a notable exception is cardiac muscle which functions on ascending limb so it can increase force when stretched by an increase in preload-Starling's law). Due to the presence of elastic proteins within a muscle (such as titin), as the muscle is stretched beyond a given length, there is an entirely passive force, which opposes lengthening. Combined together, we see a strong resistance to lengthening an active muscle far beyond the peak of active force.
Force–velocity relationship: The speed at which a muscle changes length (usually regulated by external forces, such as load or other muscles) also affects the force it can generate. Force declines in a hyperbolic fashion relative to the isometric force as the shortening velocity increases, eventually reaching zero at some maximum velocity. The reverse holds true for when the muscle is stretched – force increases above isometric maximum, until finally reaching an absolute maximum. This has strong implications for the rate at which muscles can perform mechanical work (power). Since power is equal to force times velocity, the muscle generates no power at either isometric force (due to zero velocity) or maximal velocity (due to zero force). Instead, the optimal shortening velocity for power generation is approximately one-third of maximum shortening velocity.
These two fundamental properties of muscle have numerous biomechanical consequences, including limiting running speed, strength, and jumping distance and height.
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