definitions
naphazoline (n.)
1.vasoconstrictor (trade names Privine and Sudafed) used in nasal sprays to treat symptoms of nasal congestion and in eyedrops to treat eye irritation
Naphazoline (n.)
1.(MeSH)An adrenergic vasoconstrictor agent used as a decongestant.
synonyms
Naphazoline (n.) (MeSH)
D03.383.129.308.585, Abbot Brand of Naphazoline Hydrochloride (MeSH), Afazol Grin (MeSH), AK-Con (MeSH), Akorn Brand of Naphazoline Hydrochloride (MeSH), Albalon (MeSH), Alcon Brand 1 of Naphazoline Hydrochloride (MeSH), Alcon Brand 2 of Naphazoline Hydrochloride (MeSH), All Clear (MeSH), Allergan Brand of Naphazoline Hydrochloride (MeSH), Bausch&Lomb Brand 1 of Naphazoline Hydrochloride (MeSH), Bausch&Lomb Brand 2 of Naphazoline Hydrochloride (MeSH), Chauvin Brand of Naphazoline Hydrochloride (MeSH), Ciba Vision Brand 1 of Naphazoline Hydrochloride (MeSH), Ciba Vision Brand 2 of Naphazoline Hydrochloride (MeSH), Clear Eyes (MeSH), Colirio Alfa (MeSH), Febena Brand of Naphazoline Hydrochloride (MeSH), Grin Brand of Naphazoline Hydrochloride (MeSH), Idril (MeSH), Iquinosa Brand of Naphazoline Hydrochloride (MeSH), Miraclar (MeSH), Nafazair (MeSH), Naphazoline Hydrochloride (MeSH), Naphazoline Monohydrochloride (MeSH), Naphazoline Nitrate (MeSH), Naphcon (MeSH), Naphcon forte (MeSH), Novartis Brand 1 of Naphazoline Hydrochloride (MeSH), Novartis Brand 2 of Naphazoline Hydrochloride (MeSH), Optazine (MeSH), Optima Brand of Naphazoline Hydrochloride (MeSH), Privin (MeSH), Privine (MeSH), Proculin (MeSH), Ross Brand of Naphazoline Hydrochloride (MeSH), Siozwo (MeSH), Stulln Brand of Naphazoline Hydrochloride (MeSH), Tele-Stulln (MeSH), Vasoclear (MeSH), Vasocon (MeSH), Vasocon Regular (MeSH), Vasoconstrictor Pensa (MeSH), VasoNit (MeSH), Warner-Lambert Brand of Naphazoline Nitrate (MeSH), Whitehall Brand of Naphazoline Hydrochloride (MeSH), Winzer Brand of Naphazoline Hydrochloride (MeSH)
phrases
Abbot Brand of Naphazoline Hydrochloride • Akorn Brand of Naphazoline Hydrochloride • Alcon Brand 1 of Naphazoline Hydrochloride • Alcon Brand 2 of Naphazoline Hydrochloride • Allergan Brand of Naphazoline Hydrochloride • Chauvin Brand of Naphazoline Hydrochloride • Febena Brand of Naphazoline Hydrochloride • Grin Brand of Naphazoline Hydrochloride • Iquinosa Brand of Naphazoline Hydrochloride • Naphazoline Hydrochloride • Naphazoline Monohydrochloride • Naphazoline Nitrate • Optima Brand of Naphazoline Hydrochloride • Ross Brand of Naphazoline Hydrochloride • Stulln Brand of Naphazoline Hydrochloride • Winzer Brand of Naphazoline Hydrochloride
analogical dictionary
cure; drug; remedy; medicine; medication; medicament; medicinal drug[Classe]
chose qui fait devenir plus mince (fr)[Classe]
(blood vessel; blood-vessel)[termes liés]
commerce[Domaine]
brandName[Domaine]
decongestant - agent - name[Hyper.]
vasoconstriction[Dérivé]
nasal decongestant - pressor, vasoconstrictive, vasoconstrictor[Hyper.]
brand, brand name, business name, make, marque, trade description, trade name[Domaine]
naphazoline (n.)
Wikipedia
Naphazoline
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| Systematic (IUPAC) name | |
| 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole | |
| Clinical data | |
| Trade names | Naphcon-a |
| AHFS/Drugs.com | monograph |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Topical |
| Identifiers | |
| CAS number | 835-31-4  |
| ATC code | R01AA08 |
| PubChem | CID 4436 |
| DrugBank | DB06711 |
| ChemSpider | 4283  |
| UNII | H231GF11BV |
| KEGG | D08253 |
| ChEMBL | CHEMBL761 |
| Chemical data | |
| Formula | C14H14N2 |
| Mol. mass | 210.274 |
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| (what is this?) (verify) |
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Naphazoline (in the hydrochloride form) is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane. It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. It is an active ingredient in several over-the-counter formulations including Clear Eyes and Naphcon eye drops.[1]
It has the molecular formula C14H14N2.HCl and a molecular weight of 246.73 g/mol.
Warnings and contraindications
A few warnings and contraindications that apply to all naphazoline-containing substances intended for medicinal use are:
- Hypersensitivity to naphazoline
- Patients taking MAO inhibitors can experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline HCl
- Use in infants and children can result in central nervous system depression, leading to coma and marked reduction in body temperature
- Should be used with caution in patients with severe cardiovascular disease including cardiac arrythmia and in patients with diabetes, especially those with a tendency toward diabetic ketoacidosis
- Drug interactions can occur with anaesthetics that sensitize the myocardium to sympathomimetics (e.g. cyclopropane or halothane cautiously)
- Exercise caution when applying prior to use of phenylephrine.
- Extended use may cause rhinitis medicamentosa, a condition of rebound nasal congestion.
A possible association with stroke has been suggested.[2]
Chemistry
Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline, is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester, and undergoes further heterocyclization into the desired imidazoline derivative upon reaction with ethylene diamine 
- A. Sonn, U.S. Patent 2,161,938 (1939).
References
- ^ "Ophthalmology: naphazoline". Tarascon Pocket Pharmacopoeia 2009. Jones and Bartlett Publishers. 2008. ISBN 0-7637-6572-4.
- ^ Zavala JA, Pereira ER, Zétola VH, Teive HA, Nóvak EM, Werneck LC (September 2004). "Hemorrhagic stroke after naphazoline exposition: case report". Arq Neuropsiquiatr 62 (3B): 889–91. PMID 15476091. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000500030&lng=en&nrm=iso&tlng=en.
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