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definitions - Neurokinin_B

Neurokinin B (n.)

1.(MeSH)A mammalian neuropeptide of 10 amino acids that belongs to the tachykinin family. It is similar in structure and action to SUBSTANCE P and NEUROKININ A with the ability to excite neurons, dilate blood vessels, and contract smooth muscles, such as those in the URINARY BLADDER and UTERUS.

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Neurokinin B

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Neurokinin B
Identifiers
CAS number86933-75-7
PubChem55583
MeSHNeurokinin+B
Properties
Molecular formulaC55H79N13O14S2
Molar mass1210.43
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Neurokinin B is a tachykinin peptide.

It is found in higher concentration in pregnant women suffering pre-eclampsia and can bind the immune-cloaking molecule phosphocholine.[1]

In December 2008, it was discovered[2] that the hormone Neurokinin B and its receptor, neurokinin 3 receptor, are critical parts of the control system that switches on the master regulator of human puberty, governed by the brain through the release of the hormone GnRH (gonadotropin releasing hormone) which starts a series of processes that ultimately leads to the production of sex hormones. Although Neurokinin B was previously known to be present in the same hypothalamic neurons as kisspeptin, another important part of the same control system for puberty, its key role was not previously appreciated.

References

  1. BBC News - Placenta 'fools body's defences'
  2. Topaloglu AK, Reimann F, Guclu M et al. (11 December 2008). [Expression error: Missing operand for > "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction"]. Nature Genetics. doi:10.1038/ng.306. Lay summary – e! Science News (2008-12-11). 


 

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