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definition - Ocfentanil

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Ocfentanil

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Ocfentanil
Systematic (IUPAC) name
N-(2-fluorophenyl)-2-methoxy-N-[1-(2-phenylethyl)piperidin-4-yl]acetamide
Identifiers
CAS number101343-69-5
ATC codenone
PubChem60575
Chemical data
FormulaC22H27FN2O2 
Mol. mass370.460 g/mol
SMILESeMolecules & PubChem
SynonymsOcfentanil
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat. ?
Legal status
Routes ?


Ocfentanil (A-3217) is an opioid analgesic that is an analogue of fentanyl and was developed in the early 1990s. It is similar to fentanyl in effects, producing strong analgesia and sedation, but is slightly more potent, with 3μg/kg of ocfentanil being equivalent to 5μg/kg of fentanyl.[1]

Side effects of fentanyl analogues are similar to those of fentanyl, and include itching, nausea and potentially serious respiratory depression which can be life-threatening.

References

  1. ^ Fletcher JE, Sebel PS, Murphy MR, Mick SA, Fein S. Comparison of ocfentanil and fentanyl as supplements to general anesthesia. Anesthesia and Analgesia. 1991 Nov;73(5):622-6. PMID 1952145

 

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