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definitions - Ogilvie_syndrome

Ogilvie Syndrome (n.)

1.(MeSH)Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.

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Ogilvie syndrome

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Ogilvie syndrome
Classification and external resources

Ogilvie syndrome is the acute pseudoobstruction and dilation of the colon in the absence of any mechanical obstruction in severely ill patients.[1]

Colonic pseudo-obstruction is characterized by massive dilatation of the cecum (diameter > 10 cm) and right colon on abdominal X-ray.[2][3] It is a type of megacolon, sometimes referred to as "acute megacolon," to distinguish it from toxic megacolon.

The condition carries the name of the British surgeon Sir William Heneage Ogilvie (1887–1971), who first reported it in 1948.[4][5][6]



Ogilvie's syndrome may occur after surgery, especially following coronary artery bypass surgery and total joint replacement.[7] It is also seen with neurologic disorders, serious infections, cardiorespiratory insufficiency, and metabolic disturbances. Drugs that disturb colonic motility (e.g., anticholinergics or opioid analgesics) contribute to the development of this condition.[2][8]


The exact mechanism behind the acute colonic pseudo-obstruction is not known. The probable explanation is imbalance in the regulation of colonic motor activity by the autonomic nervous system.[1]

Acute megacolon develops because of abnormal intestinal motility. Normal colonic motility requires integration of myogenic, neural, and hormonal influences. The enteric nervous system is independent but is connected to the central nervous system by sympathetic and parasympathetic nerves. The targets of the enteric neurons are muscle cells, secretory cells, endocrine cells, microvasculature, and inflammatory cells. The neurons in the enteric plexuses are stimulated by a food bolus, which both distends the gut and stimulates the mucosal surface, leading to the release of factors that stimulate interneurons. The stimulated interneurons transmit excitatory signals proximally, which cause contraction and inhibitory signals distally, and these in turn cause relaxation. These signals are transmitted by the neurotransmitters acetylcholine and serotonin, among others.[9]

Acute megacolon can also lead to ischemic necrosis in massively dilated intestinal segments. This is explained by Pascal's principle and Laplaces's law. Pascal's principle states that the pressure within a cylindrical structure is the same, regardless of whether the structure is dilated, and Laplace's law states that the wall tension of a cylinder is equal to the pressure within the cylinder multiplied by the radius. Therefore, a dilated intestinal segment has a greater wall tension than a nondilated segment; if the dilatation and tension are sufficiently great, blood flow may be obstructed and ischemia of the bowel will occur. [9]

Signs and symptoms

Usually the patient has abdominal distention, pain and altered bowel movements.[2][8] There may also be nausea and vomiting. [10]


It usually resolves with conservative therapy stopping oral ingestions, i.e. nil per os and a nasogastric tube,[2] but may require colonoscopic decompression which is successful in 70% of the cases. A study published in the New England Journal of Medicine showed that neostigmine is a potent pharmacological way of decompressing the colon.[1] According to the American Society for Gastrointestinal Endoscopy (ASGE), it should be considered prior to colonoscopic decompression. The use of neostigmine is not without risk since it can induce bradyarrhythmia and bronchospasms.[8] Therefore atropine should be within immediate reach when this therapy is used.[1][2][3]


It is a serious medical disorder and the mortality rate can be as high as 30%.[8] The high mortality rate is likely a measure that this syndrome is seen in critically ill patients, rather than this syndrome being in itself lethal, although it can also present in otherwise healthy individuals (especially if the disorder was induced by pharmocologic agents). Drug induced megacolon (i.e. from Clozapine) has been associated with mortality as high as 27.5%. <ref="NEJM_2"/>

See also


  1. ^ a b c d Ponec RJ, Saunders MD, Kimmey MB (1999). "Neostigmine for the treatment of acute colonic pseudo-obstruction". N. Engl. J. Med. 341 (3): 137–41. doi:10.1056/NEJM199907153410301. PMID 10403850. http://content.nejm.org/cgi/content/abstract/341/3/137. 
  2. ^ a b c d e Feldman, Mark; Lawrence S. Friedman, Marvin H. Sleisenger (July 2002). Sleisenger & Fordtran's Gastrointestinal and Liver Disease, 7th edition. Elsevier. ISBN 9780721689739. 
  3. ^ a b Pratt DS, Epstein SK (2000). "Recent advances in critical care gastroenterology". Am. J. Respir. Crit. Care Med. 161 (5): 1417–20. PMID 10806132. http://ajrccm.atsjournals.org/cgi/content/full/161/5/1417. 
  4. ^ Ogilvie H (1948). [Expression error: Missing operand for > "Large-intestine colic due to sympathetic deprivation: a new clinical syndrome"]. Br Med J 2: 671–673. doi:10.1136/bmj.2.4579.671.  Reproduced in: Ogilvie WH (December 1987). [Expression error: Missing operand for > "William Heneage Ogilvie 1887-1971. Large-intestine colic due to sympathetic deprivation. A new clinical syndrome"]. Dis. Colon Rectum 30 (12): 984–7. doi:10.1007/BF02554291. PMID 3319452. 
  5. ^ Sir William Heneage Ogilvie at Who Named It?
  6. ^ Haubrich WS (2008). [Expression error: Missing operand for > "Ogilvie of the Ogilvie Syndrome"]. Gastroenterology 135 (2): 337. doi:10.1053/j.gastro.2008.06.071. 
  7. ^ Tenofsky PL, Beamer L, Smith RS (2000). "Ogilvie syndrome as a postoperative complication". Arch Surg 135 (6): 682–6; discussion 686–7. doi:10.1001/archsurg.135.6.682. PMID 10843364. http://archsurg.ama-assn.org/cgi/content/abstract/135/6/682. 
  8. ^ a b c d Irwin, Richard S.; Rippe, James M. (January 2003). Intensive Care Medicine. Lippincott Williams & Wilkins, Philadelphia & London. ISBN 0-7817-3548-3. 
  9. ^ a b Alam, MD, Hasan B.; Gregory L. Fricchione, MD, Alexander S.R. Guimaraes, MD, PhD, and Lawrence R. Zukerberg, MD (October 2009). "A 26-Year-Old Man with Abdominal Distention and Shock". New England Journal of Medicine 361. http://content.nejm.org/cgi/content/full/361/15/1487. 
  10. ^ Skeik N Jabr FI (2009). "Ogilvie Syndrome". Consultant 49 (2). http://www.consultantlive.com/photoclinic/article/10162/1376818. 


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