» 
Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese
Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese

definition - Oxaflozane

definition of Wikipedia

   Advertizing ▼

Wikipedia

Oxaflozane

From Wikipedia, the free encyclopedia

Jump to: navigation, search
Oxaflozane
Systematic (IUPAC) name
4-propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine
Identifiers
CAS number26629-86-7
ATC code ?
PubChem432824
ChemSpider382782
Chemical data
FormulaC14H18F3NO
Mol. mass273.29 g/mol
SMILESeMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat. ?
Legal statusUncontrolled
RoutesOral

Oxaflozane (Conflictan) is an antidepressant of the phenethylamine and morpholine chemical classes that was introduced in France in 1982, but has since been abandoned.[1][2] It is a prodrug to N-dealkyloxaflozane, which acts as a non-selective serotonin receptor agonist for the 5-HT1A (pKi = 7.1), 5-HT2A (pKi = 6.0), and 5-HT2C (pKi = 7.5) subtypes.[3] Oxaflozane may also have anticholinergic effects in high doses.[4]

References

  1. ^ "Index nominum, international drug ... - Google Books". http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA766&dq=oxaflozane%20conflictan&as_brr=3&pg=PA766#v=onepage&q=oxaflozane%20conflictan&f=false. 
  2. ^ "Pharmaceutical manufacturing ... - Google Books". http://books.google.com/books?id=XCsJgUnclbcC&lpg=PA1122&dq=oxaflozane%20conflictan&as_brr=3&pg=PA1122#v=onepage&q=oxaflozane%20conflictan&f=false. 
  3. ^ Leysen DC (February 1999). [Expression error: Missing operand for > "Selective 5-HT2C agonists as potential antidepressants"]. IDrugs : the Investigational Drugs Journal 2 (2): 109–20. PMID 16160946. 
  4. ^ Dutertre JP, Barbier P, Suc AL, Jonville AP, Autret E (1992). [Expression error: Missing operand for > "Oxaflozane overdose in a child"]. Journal of Toxicology. Clinical Toxicology 30 (1): 123–6. PMID 1542141. 

Further reading

  • Rascol A, Maurel H, David J, Layani M (1974). [Expression error: Missing operand for > "[Preliminary clinical results of a new non tricyclic antidepressive drug: oxaflozane]"] (in French). Thérapie 29 (1): 95–9. PMID 4603757. 
  • Hache J, Duchene-Marullaz P, Streichenberger G (1974). [Expression error: Missing operand for > "[Pharmacological profile of a new non tricyclic antidepressant: oxaflozane (1,766 Cerm)]"] (in French). Thérapie 29 (1): 81–93. PMID 4849381. 
  • Constantin M, Pognat JF (1979). [Expression error: Missing operand for > "Comparative study of oxaflozane urinary metabolism in man, the dog and the rat. Identification of the principal metabolites"]. Arzneimittel-Forschung 29 (1): 109–14. PMID 582104. 
  • Bertolino A, palermo M, Porro V (1985). [Expression error: Missing operand for > "Oxaflozane, a new nontricyclic antidepressant in the treatment of anxiety-depressions syndromes."]. Acta Ther (11): 209–218. 
  • Aguglia E (1986). [Expression error: Missing operand for > "On the therapetic value of axaflozane: Its application in the treatment of emotional disturbances of the anxious-depressive type accompanied by somatic manifestations."]. Acta Ther (12): 259–267. 

External links



 

All translations of Oxaflozane


sensagent's content

  • definitions
  • synonyms
  • antonyms
  • encyclopedia

Dictionary and translator for handheld

⇨ New : sensagent is now available on your handheld

   Advertising ▼

sensagent's office

Shortkey or widget. Free.

Windows Shortkey: sensagent. Free.

Vista Widget : sensagent. Free.

Webmaster Solution

Alexandria

A windows (pop-into) of information (full-content of Sensagent) triggered by double-clicking any word on your webpage. Give contextual explanation and translation from your sites !

Try here  or   get the code

SensagentBox

With a SensagentBox, visitors to your site can access reliable information on over 5 million pages provided by Sensagent.com. Choose the design that fits your site.

Business solution

Improve your site content

Add new content to your site from Sensagent by XML.

Crawl products or adds

Get XML access to reach the best products.

Index images and define metadata

Get XML access to fix the meaning of your metadata.


Please, email us to describe your idea.

WordGame

The English word games are:
○   Anagrams
○   Wildcard, crossword
○   Lettris
○   Boggle.

Lettris

Lettris is a curious tetris-clone game where all the bricks have the same square shape but different content. Each square carries a letter. To make squares disappear and save space for other squares you have to assemble English words (left, right, up, down) from the falling squares.

boggle

Boggle gives you 3 minutes to find as many words (3 letters or more) as you can in a grid of 16 letters. You can also try the grid of 16 letters. Letters must be adjacent and longer words score better. See if you can get into the grid Hall of Fame !

English dictionary
Main references

Most English definitions are provided by WordNet .
English thesaurus is mainly derived from The Integral Dictionary (TID).
English Encyclopedia is licensed by Wikipedia (GNU).

Copyrights

The wordgames anagrams, crossword, Lettris and Boggle are provided by Memodata.
The web service Alexandria is granted from Memodata for the Ebay search.
The SensagentBox are offered by sensAgent.

Translation

Change the target language to find translations.
Tips: browse the semantic fields (see From ideas to words) in two languages to learn more.

last searches on the dictionary :

3783 online visitors

computed in 0.094s

   Advertising ▼

I would like to report:
section :
a spelling or a grammatical mistake
an offensive content(racist, pornographic, injurious, etc.)
a copyright violation
an error
a missing statement
other
please precise:

Advertize

Partnership

Company informations

My account

login

registration

   Advertising ▼