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definitions - Paraldehyde

paraldehyde (n.)

1.a colorless liquid (a cyclic trimer of acetaldehyde) that is used as a sedative and a solvent

Paraldehyde (n.)

1.(MeSH)A hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment. (From Martindale, The Extra Pharmacopoeia, 30th ed, p608-9)

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synonyms - Paraldehyde

paraldehyde (n.)

ethanal trimer

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Wikipedia

Paraldehyde

                   
Paraldehyde
Identifiers
CAS number 123-63-7 YesY
ChemSpider 21106173 YesY
UNII S6M3YBG8QA YesY
EC number 204-639-8
MeSH Paraldehyde
ChEBI CHEBI:27909 YesY
ChEMBL CHEMBL1410743 N
ATC code N05CC05
Jmol-3D images Image 1
Properties
Molecular formula C6H12O3
Molar mass 132.16 g mol−1
Melting point

12 °C, 285 K, 54 °F ([1])

Boiling point

124 °C, 397 K, 255 °F ([1])

Solubility in water insoluble
Pharmacology
Routes of
administration
Oral/Rectal/Injection
Legal status

POM(UK)

Pregnancy
category
C(US)
Hazards
MSDS External MSDS
EU classification Harmful Xn Corrosive C
R-phrases R10 R20 R21 R22 R34 R45
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Paraldehyde is the cyclic trimer of acetaldehyde molecules. Formally, it is a derivative of 1,3,5-trioxane. The corresponding tetramer is metaldehyde. A colourless liquid, it is sparingly soluble in water and highly soluble in alcohol. Paraldehyde slowly oxidizes in air, turning brown and producing an odour of acetic acid. It quickly reacts with most plastics and rubber.

Paraldehyde was first synthesized in 1829 by Wildenbusch.[2] It has uses in industry and medicine.

Contents

  Stereochemistry

Theoretically four stereoisomeric structures are possible. The structures (1) and (2) are known as cis- and trans-paraldehyde. The structures (3) (a conformer of (2)) and (4) (a conformer of (1)) don't exist for steric reasons.[3][4]

stereochemistry of paraldehyd

  Reactions

Heated with catalytic amounts of acid, it depolymerizes back to acetaldehyde:[5][6]

C6H12O3 → 3CH3CHO

Since paraldehyde has better handling characteristics, it may be used indirectly or directly as a synthetic equivalent of anhydrous acetaldehyde (b.p. 20 °C). For example, it is used as-is in the synthesis of bromal (tribromoacetaldehyde):[7]

C6H12O3 + 9 Br2 → 3 CBr3CHO + 9 HBr

  Medical applications

Paraldehyde was introduced into clinical practice in the UK by the Italian physician Vincenzo Cervello in 1882.[2]

It is a CNS depressant and was soon found to be an effective anticonvulsant, hypnotic and sedative. It was included in some cough medicines as an expectorant (though there is no known mechanism for this function beyond the placebo effect).

Paraldehyde was the last injection given to Edith Alice Morrell in 1950 by the suspected serial killer John Bodkin Adams. He was tried for her murder but acquitted.

  As a hypnotic/sedative

It was commonly used to induce sleep in sufferers from delirium tremens but has been replaced by other drugs in this regard. It is one of the safest hypnotics and was regularly given at bedtime in psychiatric hospitals and geriatric wards up to the 1960s. Up to 30% of the dose is excreted via the lungs (the rest via the liver). This contributes to a strong unpleasant odour on the breath.

  As anti-seizure

It has been used in the treatment of convulsions.[8]

Today, paraldehyde is sometimes used to treat status epilepticus. Unlike diazepam and other benzodiazepines, it does not suppress breathing at therapeutic doses and so is safer when no resuscitation facilities exist or when the patient's breathing is already compromised.[9] This makes it a useful emergency medication for parents and other caretakers of children with epilepsy. Since the dose margin between the anticonvulsant and hypnotic effect is small, paraldehyde treatment usually results in sleep.

  Administration

  A 5ml glass ampoule of Paraldehyde.

Generic paraldehyde is available in 5ml sealed glass ampoules. Production in the US has been discontinued, but it was previously marketed as Paral.

Paraldehyde has been given orally, rectally, intravenously and by intramuscular injection. It reacts with rubber and plastic which limits the time it may safely be kept in contact with some syringes or tubing before administration.

  • Injection. Intramuscular injection can be very painful and lead to sterile abscesses, nerve damage, and tissue necrosis. Intravenous administration can lead to pulmonary edema, circulatory collapse and other complications.
  • Oral. Paraldehyde has a hot burning taste and can upset the stomach. It is often mixed with milk or fruit juice in a glass cup and stirred with a metal spoon.
  • Rectal. It may be mixed 1 part paraldehyde with 9 parts saline or, alternatively, with an equal mixture of peanut or olive oil.


  Industrial applications

Paraldehyde is used in resin manufacture, as a preservative, and in other processes as a solvent.

It has been used in the generation of aldehyde fuchsin.[10]

  References

  1. ^ a b Oxford MSDS
  2. ^ a b López-Muñoz F, Ucha-Udabe R, Alamo C (December 2005). "The history of barbiturates a century after their clinical introduction". Neuropsychiatric disease and treatment 1 (4): 329–43. PMC 2424120. PMID 18568113. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2424120. 
  3. ^ Kewley, R.: Microwave spectrum of paraldehyde in Can. J. Chem. 48 (1970), 852–855
  4. ^ Carpenter, D.C., Brockway, L.O.: The Electron Diffration Study of Paraldehyde in J. Amer. Chem. Soc. 58 (1936), 1270–1273
  5. ^ Kendall, E. C.; McKenzie, B. F. (1941), "dl-Alanine", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv1p0021 ; Coll. Vol. 1: 21 
  6. ^ Nathan L. Drake and Giles B. Cooke (1943), "Methyl isopropyl carbinol", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv2p0406 ; Coll. Vol. 2: 406 
  7. ^ F. A. Long and J. W. Howard, "Bromal", Org. Synth., http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv2p0087 ; Coll. Vol. 2: 87 
  8. ^ Townend W, Mackway-Jones K (January 2002). "Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Phenytoin or paraldehyde as the second drug for convulsions in children". Emergency medicine journal : EMJ 19 (1): 50. DOI:10.1136/emj.19.1.50. PMC 1725762. PMID 11777879. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1725762. 
  9. ^ Norris E, Marzouk O, Nunn A, McIntyre J, Choonara I (1999). "Respiratory depression in children receiving diazepam for acute seizures: a prospective study". Dev Med Child Neurol 41 (5): 340–3. DOI:10.1017/S0012162299000742. PMID 10378761. http://journals.cambridge.org/production/action/cjoGetFulltext?fulltextid=2316. 
  10. ^ Nettleton GS (February 1982). "The role of paraldehyde in the rapid preparation of aldehyde fuchsin". The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 30 (2): 175–8. PMID 6174561. http://www.jhc.org/cgi/pmidlookup?view=long&pmid=6174561. 

  External links

   
               

 

All translations of Paraldehyde


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