Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese
Arabic Bulgarian Chinese Croatian Czech Danish Dutch English Estonian Finnish French German Greek Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Korean Latvian Lithuanian Malagasy Norwegian Persian Polish Portuguese Romanian Russian Serbian Slovak Slovenian Spanish Swedish Thai Turkish Vietnamese

definitions - Phenazocine

Phenazocine (n.)

1.(MeSH)An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)

   Advertizing ▼

definition (more)

definition of Wikipedia

synonyms - Phenazocine

   Advertizing ▼


analogical dictionary



Phenazocine (n.) [MeSH]



From Wikipedia, the free encyclopedia

Jump to: navigation, search
Systematic (IUPAC) name
(2R,6R,11R)- 6,11-dimethyl- 3-(2-phenylethyl)- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin- 8-ol
CAS number127-35-5
ATC codeN02AD02
Chemical data
Mol. mass321.45588 g/mol
SynonymsFenazocina, Phenazocinum, DEA No. 9715
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat. ?
Legal status ? (UK)

Phenazocine (brandnames Prinadol, Narphen) is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects.

Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors.[1]

Phenazocine appears to be a much stronger analgesic with fewer side effects than pentazocine, probably due to a more favorable μ/κ binding ratio. Phenazocine is a much more potent analgesic than pentazocine and other drugs in the benzomorphan series, most probably due to the presence of an N-phenethyl substitution, which is known to boost μ-opioid activity in many classes of opioid analgesics.[2]

Consequently phenazocine is some 4x the potency of morphine as an analgesic. Also it does not cause spasm of the sphincter of Oddi, making it more suitable than morphine for the treatment of biliary or pancreatic pain.[3]


Phenazocine was invented in the 1950s. [4][5] It was one of a number of benzomorphan opioids (including pentazocine, dezocine, and cyclazocine) developed in the search for non-addictive strong analgesics.

Phenazocine was once widely used, and was mainly supplied as 5mg tablets of the hydrobromide salt for sublingual use (Narphen, Prinadol and other names), but its use was discontinued in the United Kingdom in 2001.[6]

Phenazocine was briefly used in the United States but fell out of favour for the above-mentioned reasons; it remains a Schedule II substance under the Comprehensive Drug Abuse Control & Prevention Act (aka Controlled Substances Act) of 1970 (CSA) but is not manufactured; other Schedule II narcotics not in use in the United States include bezitramide and metopon.


  1. ^ Harris LS, Pierson AK (February 1964). [Expression error: Missing operand for > "Some Narcotic Antagonists in the Benzomorphan Series"]. Journal of Pharmacology and Experimental Therapeutics (143): 141–8. PMID 14163985. 
  2. ^ Feinberg AP, Creese I, Snyder SH (November 1976). [Expression error: Missing operand for > "The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists"]. Proceedings of the National Academy of Sciences USA 73 (11): 4215–9. doi:10.1073/pnas.73.11.4215. PMID 186791. 
  3. ^ Hopton D. (January 1971). [Expression error: Missing operand for > "Double-blind clinical trial of the analgesic effects of phenazocine hydrobromide (Narphen) compared with morphine sulphate in patients with acute abdominal pain"]. Gut 12 (1): 51–4. doi:10.1136/gut.12.1.51. PMID 4929685. 
  4. ^ Clarke EG (August 8, 1959). [Expression error: Missing operand for > "Identification of Phenazocine, a Potent New Analgesic"]. Nature (184(Suppl 7)): 451. PMID 13810504. 
  5. ^ Eckenhoff JE (May-June 1959). [Expression error: Missing operand for > "Phenazocine, a new benzomorphan narcotic analgesic"]. Anesthesiology 20 (3): 355–8. PMID 13650222. 
  6. ^ "Monthly Release Terming and Coding Newsletter" (PDF). NHS Information Authority. February 2001. http://www.connectingforhealth.nhs.uk/systemsandservices/data/readcodes/docs/tandc0201.pdf. Retrieved 2008-01-11. 


All translations of Phenazocine

sensagent's content

  • definitions
  • synonyms
  • antonyms
  • encyclopedia

Dictionary and translator for handheld

⇨ New : sensagent is now available on your handheld

   Advertising ▼

sensagent's office

Shortkey or widget. Free.

Windows Shortkey: sensagent. Free.

Vista Widget : sensagent. Free.

Webmaster Solution


A windows (pop-into) of information (full-content of Sensagent) triggered by double-clicking any word on your webpage. Give contextual explanation and translation from your sites !

Try here  or   get the code


With a SensagentBox, visitors to your site can access reliable information on over 5 million pages provided by Sensagent.com. Choose the design that fits your site.

Business solution

Improve your site content

Add new content to your site from Sensagent by XML.

Crawl products or adds

Get XML access to reach the best products.

Index images and define metadata

Get XML access to fix the meaning of your metadata.

Please, email us to describe your idea.


The English word games are:
○   Anagrams
○   Wildcard, crossword
○   Lettris
○   Boggle.


Lettris is a curious tetris-clone game where all the bricks have the same square shape but different content. Each square carries a letter. To make squares disappear and save space for other squares you have to assemble English words (left, right, up, down) from the falling squares.


Boggle gives you 3 minutes to find as many words (3 letters or more) as you can in a grid of 16 letters. You can also try the grid of 16 letters. Letters must be adjacent and longer words score better. See if you can get into the grid Hall of Fame !

English dictionary
Main references

Most English definitions are provided by WordNet .
English thesaurus is mainly derived from The Integral Dictionary (TID).
English Encyclopedia is licensed by Wikipedia (GNU).


The wordgames anagrams, crossword, Lettris and Boggle are provided by Memodata.
The web service Alexandria is granted from Memodata for the Ebay search.
The SensagentBox are offered by sensAgent.


Change the target language to find translations.
Tips: browse the semantic fields (see From ideas to words) in two languages to learn more.

last searches on the dictionary :

2290 online visitors

computed in 0.047s

I would like to report:
section :
a spelling or a grammatical mistake
an offensive content(racist, pornographic, injurious, etc.)
a copyright violation
an error
a missing statement
please precise:



Company informations

My account



   Advertising ▼