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BogglePotassium large conductance calcium-activated channel, subfamily M, alpha 1
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Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 (KCa1.1) is a voltage gated ion channel encoded by the KCNMA1 gene.[1]
KCa1.1 channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. KCa1.1 channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of the KCNMA1 gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]
See also
References
Further reading
- Magleby KL (2003). [Expression error: Missing operand for > "Gating mechanism of BK (Slo1) channels: so near, yet so far."]. J. Gen. Physiol. 121 (2): 81–96. PMID 12566537.
- Wei AD, Gutman GA, Aldrich R, et al. (2006). [Expression error: Missing operand for > "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels."]. Pharmacol. Rev. 57 (4): 463–72. doi:. PMID 16382103.
- McCobb DP, Fowler NL, Featherstone T, et al. (1995). [Expression error: Missing operand for > "A human calcium-activated potassium channel gene expressed in vascular smooth muscle."]. Am. J. Physiol. 269 (3 Pt 2): H767–77. PMID 7573516.
- Butler A, Tsunoda S, McCobb DP, et al. (1993). [Expression error: Missing operand for > "mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels."]. Science 261 (5118): 221–4. PMID 7687074.
- Dworetzky SI, Trojnacki JT, Gribkoff VK (1995). [Expression error: Missing operand for > "Cloning and expression of a human large-conductance calcium-activated potassium channel."]. Brain Res. Mol. Brain Res. 27 (1): 189–93. PMID 7877450.
- Pallanck L, Ganetzky B (1995). [Expression error: Missing operand for > "Cloning and characterization of human and mouse homologs of the Drosophila calcium-activated potassium channel gene, slowpoke."]. Hum. Mol. Genet. 3 (8): 1239–43. PMID 7987297.
- Tseng-Crank J, Foster CD, Krause JD, et al. (1995). [Expression error: Missing operand for > "Cloning, expression, and distribution of functionally distinct Ca(2+)-activated K+ channel isoforms from human brain."]. Neuron 13 (6): 1315–30. PMID 7993625.
- Knaus HG, Folander K, Garcia-Calvo M, et al. (1994). [Expression error: Missing operand for > "Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle."]. J. Biol. Chem. 269 (25): 17274–8. PMID 8006036.
- Meera P, Wallner M, Jiang Z, Toro L (1996). [Expression error: Missing operand for > "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels."]. FEBS Lett. 382 (1-2): 84–8. PMID 8612769.
- Wallner M, Meera P, Ottolia M, et al. (1996). [Expression error: Missing operand for > "Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium."]. Recept. Channels 3 (3): 185–99. PMID 8821792.
- Wallner M, Meera P, Toro L (1997). [Expression error: Missing operand for > "Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus."]. Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14922–7. PMID 8962157.
- Meera P, Wallner M, Song M, Toro L (1998). [Expression error: Missing operand for > "Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus."]. Proc. Natl. Acad. Sci. U.S.A. 94 (25): 14066–71. PMID 9391153.
- Díaz L, Meera P, Amigo J, et al. (1999). [Expression error: Missing operand for > "Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel."]. J. Biol. Chem. 273 (49): 32430–6. PMID 9829973.
- Wallner M, Meera P, Toro L (1999). [Expression error: Missing operand for > "Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog."]. Proc. Natl. Acad. Sci. U.S.A. 96 (7): 4137–42. PMID 10097176.
- Valverde MA, Rojas P, Amigo J, et al. (1999). [Expression error: Missing operand for > "Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit."]. Science 285 (5435): 1929–31. PMID 10489376.
- Brenner R, Jegla TJ, Wickenden A, et al. (2000). [Expression error: Missing operand for > "Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4."]. J. Biol. Chem. 275 (9): 6453–61. PMID 10692449.
- Liu QH, Williams DA, McManus C, et al. (2000). [Expression error: Missing operand for > "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation."]. Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:. PMID 10758170.
- Quirk JC, Reinhart PH (2001). [Expression error: Missing operand for > "Identification of a novel tetramerization domain in large conductance K(ca) channels."]. Neuron 32 (1): 13–23. PMID 11604135.
- Soto MA, González C, Lissi E, et al. (2002). [Expression error: Missing operand for > "Ca(2+)-activated K+ channel inhibition by reactive oxygen species."]. Am. J. Physiol., Cell Physiol. 282 (3): C461–71. doi:. PMID 11832330.
- Wang YW, Ding JP, Xia XM, Lingle CJ (2002). [Expression error: Missing operand for > "Consequences of the stoichiometry of Slo1 alpha and auxiliary beta subunits on functional properties of large-conductance Ca2+-activated K+ channels."]. J. Neurosci. 22 (5): 1550–61. PMID 11880485.
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