Prostaglandin E receptor 3

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Prostaglandin E receptor 3 (subtype EP3)

Identifiers

Symbols

PTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; MGC141828; MGC141829; MGC27302

External IDs

OMIM: 176806 MGI: 97795 HomoloGene: 22622 IUPHAR: EP₃ GeneCards: PTGER3 Gene

Gene ontology
Molecular function	• rhodopsin-like receptor activity • receptor activity • ligand-dependent nuclear receptor activity • prostaglandin E receptor activity
Cellular component	• nuclear envelope • plasma membrane • integral to plasma membrane • membrane • integral to membrane
Biological process	• transcription, DNA-dependent • signal transduction • G-protein coupled receptor protein signaling pathway • biological_process • cell death

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
71.09 - 71.29 Mb

Chr 3:
157.5 - 157.58 Mb

PubMed search

[1]

[2]

Prostaglandin E receptor 3, also known as EP₃, is a prostaglandin receptor, encoded by the PTGER3 gene.^[1]

1 Receptor
2 Variations
3 See also
4 References
5 External links
6 Further reading

Receptor

The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.

Variations

Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.^[1]

References

^ ^a ^b "Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5733.

External links

"Prostanoid Receptors: EP₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2420.

Kotani M, Tanaka I, Ogawa Y, et al. (1995). [Expression error: Missing operand for > "Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions."]. Mol. Pharmacol. 48 (5): 869–79. PMID 7476918.
Duncan AM, Anderson LL, Funk CD, et al. (1995). [Expression error: Missing operand for > "Chromosomal localization of the human prostanoid receptor gene family."]. Genomics 25 (3): 740–2. PMID 7759114.
Schmid A, Thierauch KH, Schleuning WD, Dinter H (1995). [Expression error: Missing operand for > "Splice variants of the human EP3 receptor for prostaglandin E2."]. Eur. J. Biochem. 228 (1): 23–30. PMID 7883006.
An S, Yang J, So SW, et al. (1995). [Expression error: Missing operand for > "Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals."]. Biochemistry 33 (48): 14496–502. PMID 7981210.
Regan JW, Bailey TJ, Donello JE, et al. (1994). [Expression error: Missing operand for > "Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini."]. Br. J. Pharmacol. 112 (2): 377–85. PMID 8075855.
Yang J, Xia M, Goetzl EJ, An S (1994). [Expression error: Missing operand for > "Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2."]. Biochem. Biophys. Res. Commun. 198 (3): 999–1006. PMID 8117308.
Kunapuli SP, Fen Mao G, Bastepe M, et al. (1994). [Expression error: Missing operand for > "Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells."]. Biochem. J. 298 ( Pt 2): 263–7. PMID 8135729.
Adam M, Boie Y, Rushmore TH, et al. (1994). [Expression error: Missing operand for > "Cloning and expression of three isoforms of the human EP3 prostanoid receptor."]. FEBS Lett. 338 (2): 170–4. PMID 8307176.
Chang C, Negishi M, Nishigaki N, Ichikawa A (1997). [Expression error: Missing operand for > "Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype."]. Biochem. J. 322 ( Pt 2): 597–601. PMID 9065782.
Kotani M, Tanaka I, Ogawa Y, et al. (1997). [Expression error: Missing operand for > "Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)."]. Genomics 40 (3): 425–34. doi:10.1006/geno.1996.4585. PMID 9073510.
Ushikubi F, Segi E, Sugimoto Y, et al. (1998). [Expression error: Missing operand for > "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3."]. Nature 395 (6699): 281–4. doi:10.1038/26233. PMID 9751056.
Bhattacharya M, Peri K, Ribeiro-da-Silva A, et al. (1999). [Expression error: Missing operand for > "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope."]. J. Biol. Chem. 274 (22): 15719–24. PMID 10336471.
Liu J, Akahoshi T, Jiang S, et al. (2000). [Expression error: Missing operand for > "Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3."]. J. Leukoc. Biol. 68 (2): 187–93. PMID 10947062.
Kurihara Y, Endo H, Kondo H (2001). [Expression error: Missing operand for > "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells."]. Inflamm. Res. 50 (1): 1–5. PMID 11235015.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Matsuoka Y, Furuyashiki T, Bito H, et al. (2003). [Expression error: Missing operand for > "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes."]. Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–7. doi:10.1073/pnas.0633341100. PMID 12642666.
Wing DA, Goharkhay N, Hanna M, et al. (2003). [Expression error: Missing operand for > "EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium."]. J. Soc. Gynecol. Investig. 10 (3): 124–9. PMID 12699873.
Abulencia JP, Gaspard R, Healy ZR, et al. (2003). [Expression error: Missing operand for > "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells."]. J. Biol. Chem. 278 (31): 28388–94. doi:10.1074/jbc.M301378200. PMID 12743126.
Richards JA, Brueggemeier RW (2003). [Expression error: Missing operand for > "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes."]. J. Clin. Endocrinol. Metab. 88 (6): 2810–6. PMID 12788892.
Moreland RB, Kim N, Nehra A, et al. (2004). [Expression error: Missing operand for > "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum."]. Int. J. Impot. Res. 15 (5): 362–8. doi:10.1038/sj.ijir.3901042. PMID 14562138.

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Transmembrane receptor: G protein-coupled receptors

Class A: Rhodopsin like

Adrenergic	α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3
Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182)
Purinergics	Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotonin	(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)
Other	Acetylcholine (M1, M2, M3, M4, M5) · Adrenomedullin · Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bile acid · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Cannabinoid (CB1, CB2) · Chemokine · Cholecystokinin (A, B) · Dopamine (D1, D2, D3, D4, D5) · EBI2 · Endothelin (A, B) · Estrogen · Formyl peptide (1, 2, 3) · Free fatty acid (1, 2, 3, 4) · FSH · Galanin (1, 2, 3) · Gonadotropin-releasing hormone (1, 2) · GHB receptor · Ghrelin · Histamine (H1, H2, H3, H4) · Kisspeptin · Luteinizing hormone/choriogonadotropin · lysophosphatidic acid (1, 2, 3, 4, 5, 6) · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Melatonin (1A, 1B, 1C) · Niacin (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Orexin (1, 2) · Oxytocin · Oxoglutarate · PAF · Prokineticin (1, 2) · Prolactin-releasing peptide · Protease-activated (1, 2, 3, 4) · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · SREB · Succinate · TAAR (1, 2, 3, 5, 6, 8, 9) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Frizzled / Smoothened

Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) · Smoothened

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Arabic	Bulgarian	Chinese	Czech
Danish	Dutch	English	Estonian
Finnish	French	German	Greek
Hungarian	Italian	Japanese	Korean
Norwegian	Polish	Portuguese	Romanian
Russian	Serbian	Slovenian	Spanish
Swedish	Turkish	Latvian	Persian
Lithuanian	Icelandic	Slovak	Croatian
Hindi	Vietnamese	Hebrew	Thai
Indonesian

Wikipedia

Prostaglandin E receptor 3

From Wikipedia, the free encyclopedia

Contents

Receptor

Variations

See also

References

External links

Further reading