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Wikipedia

Protein THEMIS

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thymocyte selection associated
Identifiers
SymbolsTHEMIS; C6orf190; TSEPA; FLJ40584; C6orf207; MGC163388
External IDsMGI: 2443552 HomoloGene: 72287 GeneCards: THEMIS Gene
Orthologs
SpeciesHumanMouse
Entrez387357210757
EnsemblENSG00000172673ENSMUSG00000049109
UniProtQ8N1K5Q8BGW0
RefSeq (mRNA)NM_001010923NM_178666
RefSeq (protein)NP_001010923NP_848781
Location (UCSC)Chr 6:
128.07 - 128.28 Mb		Chr 10:
28.39 - 28.6 Mb
PubMed search[1][2]

Protein THEMIS is a protein that in humans is encoded by the THEMIS gene.[1][2][3]

Contents

Function

This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[4]

The name

THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since protein is important in deciding the fate of the T cell during development.[5]

References

  1. ↑ Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, Brockmeyer C, Salek M, Fallen PR, Hoerter JA, Munshi A, Huang YH, Hu J, Fox HS, Sauer K, Acuto O, Gascoigne NR (August 2009). [Expression error: Missing operand for > "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling"]. Nat. Immunol. 10 (8): 848–56. doi:10.1038/ni.1766. PMID 19597499. 
  2. ↑ Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE (August 2009). [Expression error: Missing operand for > "Themis, a T cell-specific protein important for late thymocyte development"]. Nat. Immunol. 10 (8): 840–7. doi:10.1038/ni.1768. PMID 19597498. 
  3. ↑ Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH (August 2009). [Expression error: Missing operand for > "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection"]. Nat. Immunol. 10 (8): 831–9. doi:10.1038/ni.1769. PMID 19597497. 
  4. ↑ "Entrez Gene: thymocyte selection associated". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387357. 
  5. ↑ Zielinska E (2009-11-01). "Six degrees of science". The Scientist. http://www.the-scientist.com/2009/11/1/18/1/. 

Further reading

  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). [Expression error: Missing operand for > "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."]. Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). [Expression error: Missing operand for > "Creation of genome-wide protein expression libraries using random activation of gene expression."]. Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013. 
  • Allen PM (2009). [Expression error: Missing operand for > "Themis imposes new law and order on positive selection."]. Nat. Immunol. 10 (8): 805-6. doi:10.1038/ni0809-805. PMID 19621038. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.

 

All translations of Protein_THEMIS


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