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Wikipedia

RFX2

From Wikipedia, the free encyclopedia

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Regulatory factor X, 2 (influences HLA class II expression)
Identifiers
SymbolsRFX2; FLJ14226
External IDsOMIM: 142765 MGI: 106583 HomoloGene: 30980 GeneCards: RFX2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez599019725
EnsemblENSG00000087903ENSMUSG00000024206
UniProtP48378P48379
RefSeq (mRNA)NM_000635NM_009056
RefSeq (protein)NP_000626NP_033082
Location (UCSC)Chr 19:
5.94 - 6.06 Mb		Chr 17:
56.46 - 56.52 Mb
PubMed search[1][2]

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.[1][2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.[2]

References

  1. ^ Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). [Expression error: Missing operand for > "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19"]. Genomics 13 (4): 1307-10. PMID 1505960. 
  2. ^ a b "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5990. 

Further reading

  • Reith W, Ucla C, Barras E, et al. (1994). [Expression error: Missing operand for > "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins."]. Mol. Cell. Biol. 14 (2): 1230–44. PMID 8289803. 
  • Doyle J, Hoffman S, Ucla C, et al. (1996). [Expression error: Missing operand for > "Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins."]. Genomics 35 (1): 227–30. doi:10.1006/geno.1996.0343. PMID 8661125. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). [Expression error: Missing operand for > "Generation and analysis of 280,000 human expressed sequence tags."]. Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. 
  • Iwama A, Pan J, Zhang P, et al. (1999). [Expression error: Missing operand for > "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains."]. Mol. Cell. Biol. 19 (6): 3940–50. PMID 10330134. 
  • Morotomi-Yano K, Yano K, Saito H, et al. (2002). [Expression error: Missing operand for > "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members."]. J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486. 
  • Sengupta PK, Fargo J, Smith BD (2002). [Expression error: Missing operand for > "The RFX family interacts at the collagen (COL1A2) start site and represses transcription."]. J. Biol. Chem. 277 (28): 24926–37. doi:10.1074/jbc.M111712200. PMID 11986307. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). [Expression error: Missing operand for > "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."]. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). [Expression error: Missing operand for > "Complete sequencing and characterization of 21,243 full-length human cDNAs."]. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Maijgren S, Sur I, Nilsson M, Toftgård R (2004). [Expression error: Missing operand for > "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element."]. Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578. 
  • Horvath GC, Kistler WS, Kistler MK (2005). [Expression error: Missing operand for > "RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis."]. Biol. Reprod. 71 (5): 1551–9. doi:10.1095/biolreprod.104.032268. PMID 15229132. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). [Expression error: Missing operand for > "Towards a proteome-scale map of the human protein-protein interaction network."]. Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

External links


This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

All translations of RFX2


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