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definition - SREBF2

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SREBF2

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Sterol regulatory element binding transcription factor 2

PDB rendering based on 1ukl.
Available structures
1ukl
Identifiers
SymbolsSREBF2; SREBP2
External IDsOMIM600481 MGI107585 HomoloGene20966 GeneCards: SREBF2 Gene
Orthologs
SpeciesHumanMouse
Entrez672120788
EnsemblENSG00000198911ENSMUSG00000022463
UniProtQ12772n/a
RefSeq (mRNA)NM_004599NM_033218
RefSeq (protein)NP_004590NP_150087
Location (UCSC)Chr 22:
40.56 - 40.63 Mb
Chr 15:
81.97 - 82.03 Mb
PubMed search[1][2]

Sterol regulatory element-binding protein 2 is a protein that in humans is encoded by the SREBF2 gene.[1]

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.[2]

Contents

Interactions

SREBF2 has been shown to interact with INSIG1[3][4] and CREB binding protein.[5]

See also

References

  1. ^ Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X (Jan 1994). [Expression error: Missing operand for > "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element"]. Proc Natl Acad Sci U S A 90 (24): 11603–7. PMID 7903453. 
  2. ^ "Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6721. 
  3. ^ Dobrosotskaya, Irina Y; Goldstein Joseph L, Brown Michael S, Rawson Robert B (Sep. 2003). [Expression error: Missing operand for > "Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs"]. J. Biol. Chem. (United States) 278 (37): 35837–43. doi:10.1074/jbc.M306476200. ISSN 0021-9258. PMID 12842885. 
  4. ^ Yang, Tong; Espenshade Peter J, Wright Michael E, Yabe Daisuke, Gong Yi, Aebersold Ruedi, Goldstein Joseph L, Brown Michael S (Aug. 2002). [Expression error: Missing operand for > "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER"]. Cell (United States) 110 (4): 489–500. ISSN 0092-8674. PMID 12202038. 
  5. ^ Oliner, J D; Andresen J M, Hansen S K, Zhou S, Tjian R (Nov. 1996). [Expression error: Missing operand for > "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein"]. Genes Dev. (UNITED STATES) 10 (22): 2903–11. ISSN 0890-9369. PMID 8918891. 

Further reading

  • Osborne TF (2001). [Expression error: Missing operand for > "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin."]. Genes Dev. 15 (15): 1873–8. doi:10.1101/gad.916601. PMID 11485982. 
  • Szolkiewicz M, Chmielewski M, Nogalska A, et al. (2007). [Expression error: Missing operand for > "The potential role of sterol regulatory element binding protein transcription factors in renal injury."]. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 17 (1): 62–5. doi:10.1053/j.jrn.2006.10.009. PMID 17198935. 
  • Hua X, Wu J, Goldstein JL, et al. (1995). [Expression error: Missing operand for > "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13."]. Genomics 25 (3): 667–73. PMID 7759101. 
  • Yokoyama C, Wang X, Briggs MR, et al. (1993). [Expression error: Missing operand for > "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene."]. Cell 75 (1): 187–97. PMID 8402897. 
  • Wang X, Zelenski NG, Yang J, et al. (1996). [Expression error: Missing operand for > "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis."]. EMBO J. 15 (5): 1012–20. PMID 8605870. 
  • Hua X, Sakai J, Brown MS, Goldstein JL (1996). [Expression error: Missing operand for > "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane."]. J. Biol. Chem. 271 (17): 10379–84. PMID 8626610. 
  • Pai JT, Brown MS, Goldstein JL (1996). [Expression error: Missing operand for > "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins."]. Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5437–42. PMID 8643593. 
  • Sato R, Inoue J, Kawabe Y, et al. (1996). [Expression error: Missing operand for > "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2."]. J. Biol. Chem. 271 (43): 26461–4. PMID 8900111. 
  • Oliner JD, Andresen JM, Hansen SK, et al. (1996). [Expression error: Missing operand for > "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein."]. Genes Dev. 10 (22): 2903–11. PMID 8918891. 
  • Miserez AR, Cao G, Probst LC, Hobbs HH (1997). [Expression error: Missing operand for > "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)."]. Genomics 40 (1): 31–40. doi:10.1006/geno.1996.4525. PMID 9070916. 
  • Duncan EA, Brown MS, Goldstein JL, Sakai J (1997). [Expression error: Missing operand for > "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2."]. J. Biol. Chem. 272 (19): 12778–85. PMID 9139737. 
  • Harris IR, Farrell AM, Holleran WM, et al. (1998). [Expression error: Missing operand for > "Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis."]. J. Lipid Res. 39 (2): 412–22. PMID 9508001. 
  • Kan HY, Pissios P, Chambaz J, Zannis VI (1999). [Expression error: Missing operand for > "DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter."]. Nucleic Acids Res. 27 (4): 1104–17. PMID 9927745. 
  • Seidah NG, Mowla SJ, Hamelin J, et al. (1999). [Expression error: Missing operand for > "Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization."]. Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1321–6. PMID 9990022. 
  • Nagoshi E, Imamoto N, Sato R, Yoneda Y (1999). [Expression error: Missing operand for > "Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip."]. Mol. Biol. Cell 10 (7): 2221–33. PMID 10397761. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). [Expression error: Missing operand for > "The DNA sequence of human chromosome 22."]. Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • DeBose-Boyd RA, Brown MS, Li WP, et al. (2000). [Expression error: Missing operand for > "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi."]. Cell 99 (7): 703–12. PMID 10619424. 
  • Kotzka J, Müller-Wieland D, Roth G, et al. (2000). [Expression error: Missing operand for > "Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade."]. J. Lipid Res. 41 (1): 99–108. PMID 10627507. 
  • Yang T, Goldstein JL, Brown MS (2000). [Expression error: Missing operand for > "Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum."]. J. Biol. Chem. 275 (38): 29881–6. doi:10.1074/jbc.M005439200. PMID 10896675. 

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

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