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Wikipedia

Sarmazenil

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Sarmazenil
Systematic (IUPAC) name
Ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Identifiers
CAS number78771-13-8
ATCvet codeQV03AB91
PubChem71231
Chemical data
FormulaC15H14ClN3O3 
Mol. mass319.743 g/mol
SMILESeMolecules & PubChem
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat. ?
Legal status
Routes ?


Sarmazenil (Ro15-3505) is a drug from the benzodiazepine family. It acts as a partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant. It is used in veterinary medicine to reverse the effects of benzodiazepine sedative drugs in order to rapidly re-awaken anaethetised animals.[2][3][4]

See also

References

  1. ^ López-Romero B, Evrard G, Durant F, Sevrin M, George P. Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil. Bioorganic and Medicinal Chemistry. 1998 Oct;6(10):1745-57. PMID 9839004
  2. ^ Henke J, Roberts U, Otto K, Lendl C, Matis U, Brill T, Erhardt W. Clinical investigations of an i.m. combination anesthesia with fentanyl/climazolam/xylazine and postoperative i.v. antagonism with naloxone/sarmazenil/yohimbine in guinea pigs. (German) Tierarztliche Praxis. 1996 Feb;24(1):85-7. PMID 8720962
  3. ^ Janovsky M, Tataruch F, Ambuehl M, Giacometti M. A Zoletil-Rompun mixture as an alternative to the use of opioids for immobilization of feral red deer. Journal of Wildlife Diseases. 2000 Oct;36(4):663-9. PMID 11085427
  4. ^ Walzer C, Huber C. Partial antagonism of tiletamine-zolazepam anesthesia in cheetah. Journal of Wildlife Diseases. 2002 Apr;38(2):468-72. PMID 12038151


 

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