Succinyl coenzyme A synthetase
From Wikipedia, the free encyclopedia
Succinyl coenzyme A synthetase (succinate thiokinase) catalyzes the formation of succinate and coenzyme-A, a 4-carbon metabolite, from succinyl-CoA.
Contents |
Reaction
Succinyl-CoA synthetase catalyzes a reversible step in the citric acid cycle, which involves the substrate-level phosphorylation of GDP.
Succinyl-CoA wpmp.png | Succinate wpmp.png |
Isoforms
Johnson et al. describe two isoforms of succinyl-CoA synthetase in mammals, one that specifically uses ATP for synthesis, and one that utilizes GTP. [1]
The GTP form is the one more commonly used in the human citric acid cycle.[citation needed]
Structure
The crystal structure of Succinyl-CoA synthetase alpha subunit (ATP-binding isoform) was determined by Joyce et al. to a resolution of 2.10 A, with PDB code 1CQJ. [1].[2]
References
- ^ Johnson JD, Mehus JG, Tews K, Milavetz BI, Lambeth DO (1998). "Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes". J Biol Chem 273 (42): 27580–6. doi:. http://www.jbc.org/cgi/content/full/273/42/27580.
- ^ Joyce, M. A., Fraser, M. E., James, M. N. G., Bridger, W. A., and Wolodko, W. T. (2000) Biochemistry 39, 17-25
External links
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