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definitions

T-Type Calcium Channel (n.)

1.(MeSH)A heterogenous group of transient or low voltage activated type CALCIUM CHANNELS. They are found in cardiac myocyte membranes, the sinoatrial node, Purkinje cells of the heart and the central nervous system.

synonyms

T-Type Calcium Channel (n.) (MeSH)

D12.776.157.530.400.150.720, D12.776.543.550.425.150.720, D12.776.543.585.400.150.720, Calcium Channels, T-Type (MeSH)

analogical dictionary

Ion Channel, Ion Channels, Ionic Channel, Ionic Channels, Membrane Channel, Membrane Channels[Hyper.]

Calcium Channel, Calcium Channel Antagonist Receptor, Calcium Channel Antagonist Receptors, Calcium Channel Blocker Receptor, Calcium Channel Blocker Receptors, Calcium Channels, Ion Channel, Calcium, Ion Channels, Calcium, Receptors, Calcium Channel Antagonist, Receptors, Calcium Channel Blocker, VDCC, Voltage-Dependent Calcium Channels[Hyper.]

T-Type Calcium Channel (n.) [MeSH]

Wikipedia

T-type calcium channel

From Wikipedia

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calcium channel, voltage-dependent, T type, alpha 1G subunit
Identifiers
Symbol	CACNA1G
IUPHAR	Ca_v3.1
HUGO	1394
OMIM	604065
RefSeq	NM_018896
UniProt	O43497
Other data
Locus	Chr. 17 q22

calcium channel, voltage-dependent, T type, alpha 1H subunit
Identifiers
Symbol	CACNA1H
IUPHAR	Ca_v3.2
Entrez	8912
HUGO	1395
OMIM	607904
RefSeq	NM_001005407
UniProt	O95180
Other data
Locus	Chr. 16 p13.3

calcium channel, voltage-dependent, T type, alpha 1I subunit
Identifiers
Symbol	CACNA1I
IUPHAR	Ca_v3.3
Entrez	8911
HUGO	1396
OMIM	608230
RefSeq	NM_001003406
UniProt	Q9P0X4
Other data
Locus	Chr. 22 q13.1

The T-type calcium channel is a type of voltage-gated calcium channel. "T" stands for transient referring to the length of activation. As with other sub-types of voltage-gated calcium channel, the α1 subunit is the one that determines most of the channel's properties. T-type calcium channels may contain one of three α1 subunits, α1G (Cav3.1), α1H (Cav3.2) or α1I (Cav3.3)^[1]^[2]^[3].

Along with sodium "funny current," the T-type calcium channel produces the pacemaker potential in the SA node of the heart.^[4]

T-type calcium channel blockers are used primarily as antiepileptics.^[5]

References

↑ Nilius B, Talavera K, Verkhratsky A (August 2006). [Expression error: Missing operand for > "T-type calcium channels: the never ending story"]. Cell Calcium 40 (2): 81–8. doi:10.1016/j.ceca.2006.04.011. PMID 16797069.
↑ Perez-Reyes E, Lory P (December 2006). "Molecular biology of T-type calcium channels". CNS Neurol Disord Drug Targets 5 (6): 605–9. PMID 17168745. http://www.bentham-direct.org/pages/content.php?CNSNDDT/2006/00000005/00000006/0004Z.SGM.
↑ Talavera K, Nilius B (August 2006). [Expression error: Missing operand for > "Biophysics and structure-function relationship of T-type Ca2+ channels"]. Cell Calcium 40 (2): 97–114. doi:10.1016/j.ceca.2006.04.013. PMID 16777221.
↑ Mangoni ME, Couette B, Marger L, Bourinet E, Striessnig J, Nargeot J (2006). [Expression error: Missing operand for > "Voltage-dependent calcium channels and cardiac pacemaker activity: from ionic currents to genes"]. Prog. Biophys. Mol. Biol. 90 (1-3): 38–63. doi:10.1016/j.pbiomolbio.2005.05.003. PMID 15979127.
↑ Lory P, Chemin J (May 2007). [Expression error: Missing operand for > "Towards the discovery of novel T-type calcium channel blockers"]. Expert Opin. Ther. Targets 11 (5): 717–22. doi:10.1517/14728222.11.5.717. PMID 17465728.

External links

MeSH T-Type+Calcium+Channel
"Voltage-Gated Calcium Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyMenuForward?familyId=11.

Membrane transport protein: ion channels

Ca²⁺: Calcium channel

Voltage-gated	L-type/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-type/Ca_vα2.2 · P-type/Ca_vα(2.1) · Q-type/Ca_vα2.1 · R-type/Ca_vα2.3 · T-type/Ca_vα(3.1, 3.2, 3.3) α₂δ-subunits (1, 2) · β-subunits (β1, β2, β3, β4) · γ-subunits (γ1, γ2, γ3, γ4) Cation channels of sperm (1, 2, 3, 4) · Two-pore channel (1, 2)
Ligand-gated	Inositol trisphosphate receptor (1, 2, 3) · Ryanodine receptor (1, 2, 3)

Na⁺: Sodium channel

Voltage-gated	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)
Constitutively active	Epithelial sodium channel (α, β, γ, δ)

K⁺: Potassium channel

Voltage-gated	K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.10) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-like · MiRP (1, 2, 3) · Shaker gene
Calcium-activated	BK channel (α1, β1, β2, β3, β4) · SK channel (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
Inward-rectifier	K_ir (1.1, 2.1, 2.2, 2.3, 2.4) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
Tandem pore domain	K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Other

M⁺: TRP cation channel	TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)
Cl^-: Chloride channel	ANO1 · Bestrophin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)
Cyclic nucleotide-gated (FC)	α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)
Porin	Aquaporin (1, 2, 3, 4, 5, 7, 8, 9) · Voltage-dependent anion channel (1, 2, 3) · General bacterial porin family
General	Ligand-gated ion channel · Voltage-gated ion channel · Stretch-activated ion channel
see also disorders

All translations of T-type calcium channel

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Danish (da)	Dutch (nl)	English (en)	Estonian (et)
Finnish (fi)	French (fr)	German (de)	Greek (el)
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definitions

T-Type Calcium Channel (n.)

synonyms

T-Type Calcium Channel (n.) (MeSH)

analogical dictionary

Wikipedia

T-type calcium channel

From Wikipedia

See also

References

External links