From Wikipedia
Betaglycan also known as Transforming growth factor, beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight. Betaglycan binds to various members of the TGF-beta superfamily of ligands via its core protein, and bFGF via its heparan sulfate chains. It is not involved directly in TGF-beta signal transduction but by binding to various member of the TGF-beta superfamily at the cell surface it acts as a reservoir of ligand for TGF-beta receptors.[1][2]
See also
References
- ↑ Andres JL, Stanley K. et al. (1989). [Expression error: Missing operand for > "Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta"]. J. Cell Biol. 109 (6 (Pt 1)): 3137–3145. doi:10.1083/jcb.109.6.3137. PMID 2592419.
- ↑ Andres JL, DeFalcis D. et al. (1992). [Expression error: Missing operand for > "Binding of two growth factor families to separate domains of the proteoglycan betaglycan"]. J. Biol. Chem. 267 (9): 5927–5930. PMID 1556106.
See also
Further reading
- Massagué J (1992). [Expression error: Missing operand for > "Receptors for the TGF-beta family."]. Cell 69 (7): 1067–70. doi:10.1016/0092-8674(92)90627-O. PMID 1319842.
- Border WA, Noble NA (1994). [Expression error: Missing operand for > "Transforming growth factor beta in tissue fibrosis."]. N. Engl. J. Med. 331 (19): 1286–92. doi:10.1056/NEJM199411103311907. PMID 7935686.
- Morén A, Ichijo H, Miyazono K (1992). [Expression error: Missing operand for > "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."]. Biochem. Biophys. Res. Commun. 189 (1): 356–62. doi:10.1016/0006-291X(92)91566-9. PMID 1333192.
- López-Casillas F, Cheifetz S, Doody J, et al. (1991). [Expression error: Missing operand for > "Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system."]. Cell 67 (4): 785–95. doi:10.1016/0092-8674(91)90073-8. PMID 1657406.
- Wang XF, Lin HY, Ng-Eaton E, et al. (1991). [Expression error: Missing operand for > "Expression cloning and characterization of the TGF-beta type III receptor."]. Cell 67 (4): 797–805. doi:10.1016/0092-8674(91)90074-9. PMID 1657407.
- Lin HY, Moustakas A, Knaus P, et al. (1995). [Expression error: Missing operand for > "The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands."]. J. Biol. Chem. 270 (6): 2747–54. PMID 7852346.
- López-Casillas F, Payne HM, Andres JL, Massagué J (1994). [Expression error: Missing operand for > "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."]. J. Cell Biol. 124 (4): 557–68. doi:10.1083/jcb.124.4.557. PMID 8106553.
- Maruyama K, Sugano S (1994). [Expression error: Missing operand for > "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides."]. Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Johnson DW, Qumsiyeh M, Benkhalifa M, Marchuk DA (1996). [Expression error: Missing operand for > "Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively."]. Genomics 28 (2): 356–7. doi:10.1006/geno.1995.1157. PMID 8530052.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). [Expression error: Missing operand for > "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library."]. Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Brown CB, Boyer AS, Runyan RB, Barnett JV (1999). [Expression error: Missing operand for > "Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart."]. Science 283 (5410): 2080–2. doi:10.1126/science.283.5410.2080. PMID 10092230.
- Gao J, Symons AL, Bartold PM (1999). [Expression error: Missing operand for > "Expression of transforming growth factor-beta receptors types II and III within various cells in the rat periodontium."]. J. Periodont. Res. 34 (2): 113–22. doi:10.1111/j.1600-0765.1999.tb02230.x. PMID 10207840.
- Lewis KA, Gray PC, Blount AL, et al. (2000). [Expression error: Missing operand for > "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling."]. Nature 404 (6776): 411–4. doi:10.1038/35006129. PMID 10746731.
- Zippert R, Bässler A, Holmer SR, et al. (2000). [Expression error: Missing operand for > "Eleven single nucleotide polymorphisms and one triple nucleotide insertion of the human TGF-beta III receptor gene."]. J. Hum. Genet. 45 (4): 250–3. doi:10.1007/s100380070035. PMID 10944857.
- Rotzer D, Roth M, Lutz M, et al. (2001). [Expression error: Missing operand for > "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."]. Embo J. 20 (3): 480–90. doi:10.1093/emboj/20.3.480. PMID 11157754.
- Blobe GC, Schiemann WP, Pepin MC, et al. (2001). [Expression error: Missing operand for > "Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling."]. J. Biol. Chem. 276 (27): 24627–37. doi:10.1074/jbc.M100188200. PMID 11323414.
- De Crescenzo G, Grothe S, Zwaagstra J, et al. (2001). [Expression error: Missing operand for > "Real-time monitoring of the interactions of transforming growth factor-beta (TGF-beta ) isoforms with latency-associated protein and the ectodomains of the TGF-beta type II and III receptors reveals different kinetic models and stoichiometries of binding."]. J. Biol. Chem. 276 (32): 29632–43. doi:10.1074/jbc.M009765200. PMID 11382746.
- Blobe GC, Liu X, Fang SJ, et al. (2001). [Expression error: Missing operand for > "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."]. J. Biol. Chem. 276 (43): 39608–17. doi:10.1074/jbc.M106831200. PMID 11546783.
External links
| Cell signaling: TGF beta signaling pathway |
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| TGF beta superfamily of ligands | TGF beta family (TGF-β1, TGF-β2, TGF-β3) Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, Myostatin/GDF8, GDF9, GDF10, GDF11, GDF15) Other ( Activin and inhibin, Anti-müllerian hormone, Nodal) | |
TGF beta receptors
(Activin, BMP) | | |
| Transducers/SMAD | | |
| Ligand inhibitors | | |
| Coreceptors | | |
| Other | |
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