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definition - TRPV2

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TRPV2

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Transient receptor potential cation channel, subfamily V, member 2

PDB rendering based on 2f37.
Available structures
2eta, 2etb, 2etc, 2f37
Identifiers
SymbolsTRPV2; MGC12549; VRL; VRL-1; VRL1
External IDsOMIM606676 MGI1341836 HomoloGene7993 IUPHAR: TRPV2 GeneCards: TRPV2 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5139322368
EnsemblENSG00000187688ENSMUSG00000018507
UniProtQ9Y5S1Q9WTR1
RefSeq (mRNA)NM_016113NM_011706
RefSeq (protein)NP_057197NP_035836
Location (UCSC)Chr 17:
16.26 - 16.28 Mb
Chr 11:
62.39 - 62.42 Mb
PubMed search[1][2]

Transient receptor potential cation channel subfamily V member 2 is a protein that in humans is encoded by the TRPV2 gene.[1][2]

Contents

Function

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.[3]

See also

References

  1. ^ Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (Apr 1999). [Expression error: Missing operand for > "A capsaicin-receptor homologue with a high threshold for noxious heat"]. Nature 398 (6726): 436-41. doi:10.1038/18906. PMID 10201375. 
  2. ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). [Expression error: Missing operand for > "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels"]. Pharmacol Rev 57 (4): 427-50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  3. ^ "Entrez Gene: TRPV2 transient receptor potential cation channel, subfamily V, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51393. 

Further reading

  • Tominaga M, Julius D (2000). [Expression error: Missing operand for > "Capsaicin receptor in the pain pathway."]. Jpn. J. Pharmacol. 83 (1): 20–4. doi:10.1254/jjp.83.20. PMID 10887936. 
  • Benham CD, Gunthorpe MJ, Davis JB (2004). [Expression error: Missing operand for > "TRPV channels as temperature sensors."]. Cell Calcium 33 (5-6): 479–87. doi:10.1016/S0143-4160(03)00063-0. PMID 12765693. 
  • Heiner I, Eisfeld J, Lückhoff A (2004). [Expression error: Missing operand for > "Role and regulation of TRP channels in neutrophil granulocytes."]. Cell Calcium 33 (5-6): 533–40. doi:10.1016/S0143-4160(03)00058-7. PMID 12765698. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

 

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