The Thorpe–Ziegler reaction or Ziegler method is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation and named after Karl Ziegler.
- Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) Link
- ^ Baron, H.; Remfry, F. G. P.; Thorpe, Y. F. J. Chem. Soc. 1904, 85, 1726.
- ^ Karl Ziegler et al. Ann. 1933, 504, 94.
- ^ Schaefer, J. P.; Bloomfield, J. J. Org. React. 1967, 15, 1. (Review)