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definitions - side effect

side effect (n.)

1.any adverse and unwanted secondary effect"a strategy to contain the fallout from the accounting scandal"

2.a secondary and usually adverse effect of a drug or therapy"severe headaches are one of the side effects of the drug"

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Wikipedia - see also

Wikipedia

Side effect

                   

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

Occasionally, drugs are prescribed or procedures performed specifically for their side effects; in that case, said side effect ceases to be a side effect, and is now an intended effect. For instance, X-rays were historically (and are currently) used as an imaging technique; the discovery of their oncolytic capability led to their employ in radiotherapy (ablation of malignant tumours).

Use of drugs for unapproved indications—that is, for their side effects—is termed off-label use. For instance, opioids, which are approved as palliative treatment for pain, may also be used for their euphoriant properties as anxiolytics or antidepressants, whether medically or recreationally.

Off-label use of drugs, although similar in meaning to side effects, is not to be confused with them; side effects describe the mechanism of action that a drug used off-label takes, whereas off-label use implies the desired consequences of using a drug for its side-effects.

Off-label use of drugs is legal; the manner in which prescription medication is to be used is solely at the discretion of the prescriber. However, the marketing of drugs towards unapproved indications is illegal; in fact, several pharmaceutical development firms have been fined for unapproved promotion of their products.

  Examples of therapeutic side-effects

  References

  1. ^ Boseley, Sarah (2006-06-17). "Drugs firm blocks cheap blindness cure". The Guardian (London). http://www.guardian.co.uk/medicine/story/0,,1799772,00.html. Retrieved 2010-05-20. 
  2. ^ Richard Gracer The Buprenorphine Effect on Depression. Naabt.org. February 2007
  3. ^ Bodkin JA. et al. (1995): "Buprenorphine Treatment of Refractory Depression", Journal of Clinical Psychopharmacology 15:49–57. PMID 7714228
  4. ^ Mood Stabilizers for Bipolar Disorder (Manic Depressive). Leeheymd.com (2003-08-01). Retrieved on 2011-08-17.
  5. ^ a b Wing DA, Powers B, Hickok D (2010). "U.S. Food and Drug Administration Drug Approval: Slow Advances in Obstetric Care in the United States". Obstetrics & Gynecology: April 2010 – Volume 115 – Issue 4 – pp 825–833 115 (4): 825–33. DOI:10.1097/AOG.0b013e3181d53843. PMID 20308845. 
  6. ^ Doxepin as a potent H2 and H2 antihistamine for epigastric distress. PMID 6859336. http://ajp.psychiatryonline.org/cgi/reprint/140/7/957. 
  7. ^ OFF-LABEL USE OF GABAPENTIN. Idaho Drug Utilization Review. Educational Leaflet
  8. ^ Pregnancy. drugs.nmihi.com
  9. ^ Medscape: Medscape Access. Emedicine.com. Retrieved on 2011-08-17.
  10. ^ Drugsdb.com Retrieved on 2011-12-18.
   
               

 

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